{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:09:48Z","timestamp":1793045388354,"version":"4.5.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    For peritonitis, a serious complication of peritoneal dialysis (PD), we investigated the relation between duration from the sign (PD effluent abnormalities) to treatment with appropriate antibiotics (ST time) and catheter removal. For 62 PD hospital patients, data of PD-related peritonitis (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009109) were collected retrospectively. We examined ST time and PD catheter removal times using univariate and multivariate analyses. The catheter removal rate in the delayed ST time group (\u2265\u200924\u00a0h) was higher than that in early ST time group (&lt;\u200924\u00a0h) (38 vs. 16%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). Concomitant tunnel infection and delayed ST time were associated with catheter removal (OR [95% CI] 32.3 [3.15\u2013329] and 3.52 [1.11\u201311.1]). Rates of catheter removal and re-development of peritonitis within 1\u00a0month after starting treatment were higher in the delayed ST time group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). PD duration at peritonitis and the first peritonitis episode were associated with delayed ST time (1.02 [1.00\u20131.04] and 3.42 [1.09\u201310.7]). Significant association was found between PD catheter removal and the start of treatment more than 24\u00a0h after appearance of abnormal effluent. Education for patients about prompt visitation at the onset of peritonitis with long PD duration might improve outcomes.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-86071-y","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T07:03:43Z","timestamp":1616396623000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Time until treatment initiation is associated with catheter survival in peritoneal dialysis-related peritonitis"],"prefix":"10.1038","volume":"11","author":[{"given":"Rikako","family":"Oki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Hamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Komaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"Doi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Kume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaomi","family":"Nangaku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,22]]},"reference":[{"key":"86071_CR1","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3747\/pdi.2018.00030","volume":"38","author":"ISPD Peritonitis Recommendations","year":"2018","unstructured":"ISPD Peritonitis Recommendations. 2016 update on prevention and treatment. Perit. Dial. Int. 38, 313. https:\/\/doi.org\/10.3747\/pdi.2018.00030 (2018).","journal-title":"Perit. Dial. Int."},{"key":"86071_CR2","doi-asserted-by":"publisher","first-page":"766","DOI":"10.3747\/pdi.2013.00074","volume":"34","author":"M Nakayama","year":"2014","unstructured":"Nakayama, M. et al. Encapsulating peritoneal sclerosis in the era of a multi-disciplinary approach based on biocompatible solutions: The NEXT-PD study. Perit. Dial. Int. 34, 766\u2013774. https:\/\/doi.org\/10.3747\/pdi.2013.00074 (2014).","journal-title":"Perit. Dial. Int."},{"key":"86071_CR3","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.2215\/CJN.14631218","volume":"14","author":"CC Szeto","year":"2019","unstructured":"Szeto, C. C. & Li, P. K. Peritoneal dialysis-associated peritonitis. Clin. J. Am. Soc. Nephrol. 14, 1100\u20131105 (2019).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"86071_CR4","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1053\/j.ajkd.2003.08.046","volume":"43","author":"P Choi","year":"2004","unstructured":"Choi, P. et al. Peritoneal dialysis catheter removal for acute peritonitis: A retrospective analysis of factors associated with catheter removal and prolonged postoperative hospitalization. Am. J. Kidney Dis. 43, 103\u2013111 (2004).","journal-title":"Am. J. Kidney Dis."},{"key":"86071_CR5","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ekir.2016.05.003","volume":"1","author":"K Muthucumarana","year":"2016","unstructured":"Muthucumarana, K. et al. The relationship between presentation and the time of initial administration of antibiotics with outcomes of peritonitis in peritoneal dialysis patients: The PROMPT study. Kidney Int. Rep. 1, 65\u201372 (2016).","journal-title":"Kidney Int. 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Development of a novel, highly quantitative in vivo model for the study of biofilm-impaired cutaneous wound healing. Wound Repair. Regen. 19, 400\u2013410 (2011).","journal-title":"Wound Repair. Regen."},{"key":"86071_CR9","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1177\/089686080802800410","volume":"28","author":"CY Yang","year":"2008","unstructured":"Yang, C. Y. et al. Determinants of catheter loss following continuous ambulatory peritoneal dialysis peritonitis. Perit. Dial. Int. 28, 361\u2013370 (2008).","journal-title":"Perit. Dial. Int."},{"key":"86071_CR10","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3747\/pdi.2016.00120","volume":"37","author":"CC Szeto","year":"2017","unstructured":"Szeto, C. C. et al. ISPD catheter-related infection recommendations: 2017 update. Perit. Dial. Int. 37, 141\u2013154. https:\/\/doi.org\/10.3747\/pdi.2016.00120 (2017).","journal-title":"Perit. Dial. 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