{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T14:49:29Z","timestamp":1767192569159,"version":"3.37.3"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/16\/25\/32136","PG\/14\/43\/30889","PG\/14\/43\/30889","FS\/16\/25\/32136"],"award-info":[{"award-number":["FS\/16\/25\/32136","PG\/14\/43\/30889","PG\/14\/43\/30889","FS\/16\/25\/32136"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Research Council","award":["MR\/K012789\/1","MR\/L002620\/1","MR\/K012789\/1"],"award-info":[{"award-number":["MR\/K012789\/1","MR\/L002620\/1","MR\/K012789\/1"]}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/K017772\/1"],"award-info":[{"award-number":["BB\/K017772\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"publisher","award":["18\/0005884","18\/0005884"],"award-info":[{"award-number":["18\/0005884","18\/0005884"]}],"id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["ISSF Funding"],"award-info":[{"award-number":["ISSF Funding"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Excessive expansion of adipose tissue in obesity typically leads to overflow and accumulation of lipids in other tissues, causing fatty liver disease and atherosclerosis. The intracellular protein, phosphoprotein enriched in astrocytes (PEA)-15 has been linked to metabolic disease but its role in lipid storage has not been examined. To delineate the role of PEA-15 in adipose tissue, we placed PEA-15<jats:sup>\u2212\/\u2212<\/jats:sup> mice on a high fat diet. These mice developed increased body weight and greater white adipose tissue expansion compared to high fat diet-fed wild type mice. This was due to increased adipocyte cell size in PEA-15<jats:sup>\u2212\/\u2212<\/jats:sup> mice consistent with greater lipid storage capacity. Surprisingly, PEA-15<jats:sup>\u2212\/\u2212<\/jats:sup> mice exhibited improvements in whole body insulin sensitivity, lower hepatic weight and decreased serum triglycerides indicating a protective phenotype. To determine effects on atherosclerosis, PEA-15<jats:sup>\u2212\/\u2212<\/jats:sup> mice were crossed with the ApoE<jats:sup>\u2212\/\u2212<\/jats:sup> mice on a high fat diet. Strikingly, these mice were protected from atherosclerosis and had less hepatic lipid accumulation despite increased adiposity. Therefore, we reveal for the first time that PEA-15 plays a novel role in regulating the expansion of adipose tissue. Decreasing PEA-15 expression increases the sequestering of lipids in adipose tissue, protecting other tissues in obesity, thereby improving metabolic health.<\/jats:p>","DOI":"10.1038\/s41598-021-86250-x","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T11:03:37Z","timestamp":1616756617000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Phosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion"],"prefix":"10.1038","volume":"11","author":[{"given":"Pola J.","family":"Verschoor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona H.","family":"Greig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin J.","family":"Rochford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Levate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirela","family":"Delibegovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alasdair","family":"Leeson-Payne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruta","family":"Dekeryte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Banks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe W.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme F.","family":"Nixon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"86250_CR1","doi-asserted-by":"publisher","first-page":"3990","DOI":"10.1172\/JCI129187","volume":"129","author":"RC Kahn","year":"2019","unstructured":"Kahn, R. C., Wang, G. & Lee, K. Y. Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome. J. Clin. Invest. 129, 3990\u20134000 (2019).","journal-title":"J. Clin. Invest."},{"key":"86250_CR2","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/s41580-018-0093-z","volume":"20","author":"AL Ghaben","year":"2019","unstructured":"Ghaben, A. L. & Scherer, P. E. Adipogenesis and metabolic health. Nat. Rev. Mol. Cell Biol. 20, 242\u2013258 (2019).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"86250_CR3","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1083\/jcb.201409063","volume":"208","author":"JM Rutkowski","year":"2015","unstructured":"Rutkowski, J. M., Stern, J. H. & Scherer, P. E. The cell biology of fat expansion. J. Cell Biol. 208, 501\u2013512 (2015).","journal-title":"J. Cell Biol."},{"key":"86250_CR4","doi-asserted-by":"publisher","first-page":"E2358","DOI":"10.3390\/ijms20092358","volume":"20","author":"M Longo","year":"2019","unstructured":"Longo, M. et al. Adipose tissue dysfunction as determinant of obesity-associated metabolic complications. Int. J. Mol. Sci. 20, E2358 (2019).","journal-title":"Int. J. Mol. Sci."},{"key":"86250_CR5","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s12263-007-0014-9","volume":"2","author":"M Slawik","year":"2007","unstructured":"Slawik, M. & Vidal-Puig, A. J. Adipose tissue expandability and the metabolic syndrome. Genes Nutr. 2, 41\u201350 (2007).","journal-title":"Genes Nutr."},{"key":"86250_CR6","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.cmet.2017.07.008","volume":"26","author":"N Stefan","year":"2017","unstructured":"Stefan, N., Schick, F. & Haring, H. U. Causes, characteristics, and consequences of metabolically unhealthy normal weight in humans. Cell Metabol. 26, 292\u2013300 (2017).","journal-title":"Cell Metabol."},{"key":"86250_CR7","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1097\/MOL.0b013e3283541cfc","volume":"23","author":"AS Wierzbicki","year":"2012","unstructured":"Wierzbicki, A. S. & Oben, J. Nonalcoholic fatty liver disease and lipids. Curr. Opin. Lipidol. 23, 345\u2013352 (2012).","journal-title":"Curr. Opin. Lipidol."},{"key":"86250_CR8","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1016\/j.metabol.2016.01.001","volume":"65","author":"JM Hazlehurst","year":"2016","unstructured":"Hazlehurst, J. M., Woods, C., Marjot, T., Cobbold, J. F. & Tomlinson, J. W. Non-alcoholic fatty liver disease and diabetes. Metabolism 65, 1096\u20131180 (2016).","journal-title":"Metabolism"},{"key":"86250_CR9","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nrcardio.2009.55","volume":"6","author":"VZ Rocha","year":"2009","unstructured":"Rocha, V. Z. & Libby, P. Obesity, inflammation, and atherosclerosis. Nat. Rev. Cardiol. 6, 399\u2013409 (2009).","journal-title":"Nat. Rev. Cardiol."},{"key":"86250_CR10","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.pcad.2018.06.004","volume":"61","author":"ME Pich\u00e9","year":"2018","unstructured":"Pich\u00e9, M. E., Poirier, P., Lemieux, I. & Despr\u00e9s, J. P. Overview of epidemiology and contribution of obesity and body fat distribution to cardiovascular disease: an update. Prog. Cardiovasc. Dis. 61, 103\u2013113 (2018).","journal-title":"Prog. Cardiovasc. Dis."},{"key":"86250_CR11","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1161\/CIRCRESAHA.115.306883","volume":"118","author":"FB Ortega","year":"2016","unstructured":"Ortega, F. B., Lavie, C. J. & Blair, S. N. Obesity and cardiovascular disease. Circ. Res. 118, 1752\u20131770 (2016).","journal-title":"Circ. Res."},{"key":"86250_CR12","first-page":"e00601","volume":"39","author":"JE Lee","year":"2019","unstructured":"Lee, J. E., Schmidt, H., Lai, B. & Ge, K. Transcriptional and epigenomic regulation of adipogenesis. Mol. Cell Biol. 39, e00601\u2013e00618 (2019).","journal-title":"Mol. Cell Biol."},{"key":"86250_CR13","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/nri1937","volume":"6","author":"H Tilg","year":"2006","unstructured":"Tilg, H. & Moschen, A. R. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat. Rev. Immunol. 6, 772\u2013783 (2006).","journal-title":"Nat. Rev. Immunol."},{"key":"86250_CR14","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.pharmthera.2014.03.006","volume":"143","author":"FH Greig","year":"2014","unstructured":"Greig, F. H. & Nixon, G. F. Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states. Pharmacol. Ther. 143, 265\u2013274 (2014).","journal-title":"Pharmacol. Ther."},{"key":"86250_CR15","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1007\/s00018-008-8489-0","volume":"66","author":"MG Valmiki","year":"2009","unstructured":"Valmiki, M. G. & Ramos, J. W. Death effector domain-containing proteins. Cell. Mol. Life Sci. 66, 814\u2013830 (2009).","journal-title":"Cell. Mol. Life Sci."},{"key":"86250_CR16","doi-asserted-by":"publisher","first-page":"E592","DOI":"10.1152\/ajpendo.00228.2009","volume":"297","author":"F Fiory","year":"2009","unstructured":"Fiory, F., Formisano, P., Perruolo, G. & Beguinot, F. Frontiers: PED\/PEA-15, a multifunctional protein controlling cell survival and glucose metabolism. Am. J. Physiol. Endocrinol. Metab. 297, E592\u2013E601 (2009).","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"86250_CR17","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S1534-5807(01)00035-1","volume":"1","author":"E Formstecher","year":"2001","unstructured":"Formstecher, E. et al. PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase. Dev. Cell. 1, 239\u2013250 (2001).","journal-title":"Dev. Cell."},{"key":"86250_CR18","doi-asserted-by":"publisher","first-page":"e006936","DOI":"10.1161\/JAHA.117.006936","volume":"6","author":"FH Greig","year":"2017","unstructured":"Greig, F. H., Kennedy, S., Gibson, G., Ramos, J. W. & Nixon, G. F. PEA-15 (phosphoprotein enriched in astrocytes-15) is a protective mediator in the vasculature and is regulated during neointimal hyperplasia. J. Am. Heart Assoc. 6, e006936 (2017).","journal-title":"J. Am. Heart Assoc."},{"key":"86250_CR19","doi-asserted-by":"publisher","first-page":"3547","DOI":"10.1038\/onc.2011.514","volume":"31","author":"FJ Sulzmaier","year":"2012","unstructured":"Sulzmaier, F. J. et al. PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D. Oncogene 31, 3547\u20133560 (2012).","journal-title":"Oncogene"},{"key":"86250_CR20","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.metabol.2018.06.001","volume":"87","author":"V Vastolo","year":"2018","unstructured":"Vastolo, V. et al. High-fat diet unveils an enhancer element at the Ped\/Pea-15 gene responsible for epigenetic memory in skeletal muscle. Metabolism 87, 70\u201379 (2018).","journal-title":"Metabolism"},{"key":"86250_CR21","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.molmet.2018.01.019","volume":"10","author":"GD Mcilroy","year":"2018","unstructured":"Mcilroy, G. D. et al. Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease. Mol. Metab. 10, 55\u201365 (2018).","journal-title":"Mol. Metab."},{"key":"86250_CR22","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.molmet.2017.06.003","volume":"6","author":"D Thompson","year":"2017","unstructured":"Thompson, D. et al. Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE\u2212\/\u2212 mouse model of atherosclerosis with alterations in IL10\/AMPK\u03b1 pathway. Mol. Metab. 6, 845\u2013853 (2017).","journal-title":"Mol. Metab."},{"key":"86250_CR23","doi-asserted-by":"publisher","first-page":"dmm042655","DOI":"10.1242\/dmm.042655","volume":"13","author":"GD Mcilroy","year":"2020","unstructured":"Mcilroy, G. D., Mitchell, S. E., Han, W., Delibegovi\u0107, M. & Rochford, J. J. Ablation of Bscl2\/seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy. Dis. Model Mech. 13, dmm042655 (2020).","journal-title":"Dis. Model Mech."},{"key":"86250_CR24","doi-asserted-by":"publisher","first-page":"9863","DOI":"10.1128\/MCB.24.22.9863-9872.2004","volume":"24","author":"JJ Rochford","year":"2004","unstructured":"Rochford, J. J. et al. ETO\/MTG8 is an inhibitor of C\/EBPbeta activity and a regulator of early adipogenesis. Mol. Cell. Biol. 24, 9863\u20139872 (2004).","journal-title":"Mol. Cell. Biol."},{"issue":"5","key":"86250_CR25","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1038\/oby.2011.371","volume":"20","author":"J Yang","year":"2012","unstructured":"Yang, J. et al. The size of large adipose cells is a predictor of insulin resistance in first-degree relatives of type 2 diabetics. Obesity (Silver Spring) 20(5), 932\u2013938 (2012).","journal-title":"Obesity (Silver Spring)"},{"key":"86250_CR26","doi-asserted-by":"publisher","first-page":"2707","DOI":"10.1016\/j.biocel.2008.04.009","volume":"40","author":"JW Ramos","year":"2008","unstructured":"Ramos, J. W. The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells. Int. J. Biochem. Cell Biol. 40, 2707\u20132719 (2008).","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"86250_CR27","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1093\/cvr\/cvr039","volume":"90","author":"I Hunter","year":"2011","unstructured":"Hunter, I., Mascall, K. S., Ramos, J. W. & Nixon, G. F. A phospholipase C\u03b31-activated pathway regulates transcription in human vascular smooth muscle cells. Cardiovasc. Res. 90, 557\u2013564 (2011).","journal-title":"Cardiovasc. Res."},{"key":"86250_CR28","doi-asserted-by":"publisher","first-page":"6503","DOI":"10.1038\/sj.onc.1204036","volume":"19","author":"JS Yordy","year":"2000","unstructured":"Yordy, J. S. & Muise-Helmericks, R. C. Signal transduction and the Ets family of transcription factors. Oncogene 19, 6503\u20136513 (2000).","journal-title":"Oncogene"},{"key":"86250_CR29","doi-asserted-by":"publisher","first-page":"34533","DOI":"10.1074\/jbc.M111.248591","volume":"286","author":"X Ge","year":"2011","unstructured":"Ge, X. et al. Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response\/Ets-like protein-1 in adipocytes. J. Biol. Chem. 286, 34533\u201334541 (2011).","journal-title":"J. Biol. Chem."},{"key":"86250_CR30","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.devcel.2009.04.006","volume":"16","author":"W Wang","year":"2009","unstructured":"Wang, W. et al. Mediator MED23 links insulin signaling to the adipogenesis transcription cascade. Dev. Cell 16, 764\u2013771 (2009).","journal-title":"Dev. Cell"},{"key":"86250_CR31","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.bbalip.2009.12.006","volume":"1801","author":"S Virtue","year":"2010","unstructured":"Virtue, S. & Vidal-Puig, A. Adipose tissue expandability, lipotoxicity and the metabolic syndrome\u2014an allostatic perspective. Biochim. Biophys. Acta. 1801, 338\u2013349 (2010).","journal-title":"Biochim. Biophys. Acta."},{"key":"86250_CR32","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1172\/JCI31021","volume":"117","author":"JY Kim","year":"2007","unstructured":"Kim, J. Y. et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J. Clin. Invest. 117, 2621\u20132637 (2007).","journal-title":"J. Clin. Invest."},{"key":"86250_CR33","doi-asserted-by":"publisher","first-page":"5005","DOI":"10.1128\/MCB.24.11.5005-5015.2004","volume":"24","author":"G Vigliotta","year":"2004","unstructured":"Vigliotta, G. et al. Overexpression of the ped\/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action. Mol. Cell. Biol. 24, 5005\u20135015 (2004).","journal-title":"Mol. Cell. Biol."},{"key":"86250_CR34","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.2337\/db15-1213","volume":"65","author":"T McLaughlin","year":"2016","unstructured":"McLaughlin, T. et al. Adipose cell size and regional fat deposition as predictors of metabolic response to overfeeding in insulin-resistant and insulin-sensitive humans. Diabetes 65, 1245\u20131254 (2016).","journal-title":"Diabetes"},{"key":"86250_CR35","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1007\/BF03347427","volume":"30","author":"M Bahceci","year":"2007","unstructured":"Bahceci, M. et al. The correlation between adiposity and adiponectin, tumor necrosis factor alpha, interleukin-6 and high sensitivity C-reactive protein levels. Is adipocyte size associated with inflammation in adults?. J. Endocrinol. Invest. 30, 210\u2013214 (2007).","journal-title":"J. Endocrinol. Invest."},{"key":"86250_CR36","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1016\/0026-0495(79)90131-8","volume":"28","author":"J Ostman","year":"1979","unstructured":"Ostman, J., Arner, P., Engfeldt, P. & Kager, L. Regional differences in the contorl of lipolysis in human adipose tissue. Metabolism 28, 1198\u20131205 (1979).","journal-title":"Metabolism"},{"key":"86250_CR37","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1080\/21623945.2015.1034920","volume":"4","author":"L Fang","year":"2015","unstructured":"Fang, L., Guo, F., Zhou, L., Stahl, R. & Grams, J. The cell size and distribution of adipocytes from subcutaneous and visceral fat is associated with type 2 diabetes mellitus in humans. Adipocyte 4, 273\u2013279 (2015).","journal-title":"Adipocyte"},{"key":"86250_CR38","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1172\/JCI88883","volume":"127","author":"C Crewe","year":"2017","unstructured":"Crewe, C., An, Y. A. & Scherer, P. E. The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. J. Clin. Invest. 127, 74\u201382 (2017).","journal-title":"J. Clin. Invest."},{"key":"86250_CR39","doi-asserted-by":"publisher","first-page":"2818","DOI":"10.1096\/fj.09-144295","volume":"24","author":"S Pastorino","year":"2010","unstructured":"Pastorino, S. et al. The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling. FASEB J. 24, 2818\u20132828 (2010).","journal-title":"FASEB J."},{"key":"86250_CR40","doi-asserted-by":"publisher","first-page":"402","DOI":"10.2337\/diabetes.54.2.402","volume":"54","author":"F Bost","year":"2005","unstructured":"Bost, F. et al. The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes 54, 402\u2013411 (2005).","journal-title":"Diabetes"},{"key":"86250_CR41","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.cmet.2017.03.005","volume":"25","author":"LD BonDurant","year":"2017","unstructured":"BonDurant, L. D. et al. FGF21 regulates metabolism through adipose-dependent and -independent mechanisms. Cell Metab. 25, 935\u2013944 (2017).","journal-title":"Cell Metab."},{"key":"86250_CR42","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.molmet.2018.03.012","volume":"12","author":"S Hong","year":"2018","unstructured":"Hong, S. et al. Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Mol. Metab. 12, 25\u201338 (2018).","journal-title":"Mol. Metab."},{"key":"86250_CR43","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1161\/CIRCULATIONAHA.117.029617","volume":"137","author":"IJ Neeland","year":"2018","unstructured":"Neeland, I. J., Poirer, P. & Despres, J. P. Cardiovascular and metabolic heterogeneity of obesity. Circulation 137, 1391\u20131406 (2018).","journal-title":"Circulation"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-86250-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-86250-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-86250-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T05:52:05Z","timestamp":1670046725000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-86250-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,26]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["86250"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-86250-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2021,3,26]]},"assertion":[{"value":"10 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"6949"}}