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Here, we describe a poorly known lineage from the Middle East, CC1153, to which several strains from humans and livestock belong. Isolates were characterised using DNA microarrays and one isolate from the United Arab Emirates was sequenced using Nanopore technology. CC1153 carries <jats:italic>agr<\/jats:italic> II and capsule type 5 genes. Enterotoxin genes are rarely present, but PVL is common. Associated <jats:italic>spa<\/jats:italic> types include t504, t903 and t13507. PVL-positive CC1153-MSSA were found in Egyptian cattle suffering from mastitis. It was also identified among humans with skin and soft tissue infections in Saudi Arabia, France and Germany. CC1153-MRSA were mainly observed in Arabian Gulf countries. Some isolates presented with a previously unknown SCC<jats:italic>mec<\/jats:italic>\/SCC<jats:italic>fus<\/jats:italic> chimeric element in which a <jats:italic>mec<\/jats:italic> B complex was found together with the fusidic acid resistance gene <jats:italic>fusC<\/jats:italic> and accompanying genes including <jats:italic>ccrA\/B-<\/jats:italic>1 recombinase genes. Other isolates carried SCC<jats:italic>mec<\/jats:italic> V elements that usually also included <jats:italic>fusC<\/jats:italic>. Distribution and emergence of CC1153-MRSA show the necessity of molecular characterization of MRSA that are resistant to fusidic acid. These strains pose a public health threat as they combine resistance to beta-lactams used in hospitals as well as to fusidic acid used in the community. Because of the high prevalence of <jats:italic>fusC<\/jats:italic>-positive MRSA in the Middle East, sequences and descriptions of SCC elements harbouring <jats:italic>fusC<\/jats:italic> and\/or <jats:italic>mecA<\/jats:italic> are reviewed. When comparing <jats:italic>fusC<\/jats:italic> and its surrounding regions from the CC1153 strain to available published sequences, it became obvious that there are four <jats:italic>fusC<\/jats:italic> alleles and five distinct types of <jats:italic>fusC<\/jats:italic> gene complexes reminiscent to the <jats:italic>mec<\/jats:italic> complexes in SCC<jats:italic>mec<\/jats:italic> elements. Likewise, they are associated with different sets of <jats:italic>ccrA\/B<\/jats:italic> recombinase genes and additional payload that might include entire <jats:italic>mec<\/jats:italic> complexes or SCC<jats:italic>mec<\/jats:italic> elements.<\/jats:p>","DOI":"10.1038\/s41598-021-86273-4","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T10:05:44Z","timestamp":1618394744000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Characterisation of S. aureus\/MRSA CC1153 and review of mobile genetic elements carrying the fusidic acid resistance gene fusC"],"prefix":"10.1038","volume":"11","author":[{"given":"Stefan","family":"Monecke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha D.","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Armengol-Porta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Bes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Boswihi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maged","family":"El-Ashker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Engelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius","family":"Gawlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayada","family":"Gwida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Hotzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania","family":"Nassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annett","family":"Reissig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Ruppelt-Lorz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abiola","family":"Senok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali M.","family":"Somily","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edet E.","family":"Udo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Ehricht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"86273_CR1","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1136\/bmj.1.5219.124-a","volume":"1","author":"MP Jevons","year":"1961","unstructured":"Jevons, M. 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