{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:26:17Z","timestamp":1784874377774,"version":"3.55.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CSF shunting with adjustable valve is the treatment of idiopathic normal pressure hydrocephalus. The opening pressure valve setting is left to the neurosurgeon\u2019s experience. Aqueductal CSF stroke volume by phase-contrast magnetic resonance measures the CSF passing through the Sylvian aqueduct and it changes with intracranial hydrodynamics. We sought to identify a window of stroke volume differences associated with the best clinical outcome and lowest rate of complications.\n The records of 69 patients were reviewed. At every clinical check, stroke volume, opening pressure valve, clinical outcome, and CSF overdrainage were analyzed. The correlation between stroke volume differences and negative outcome was also analyzed. The median follow-up was 2.3\u00a0years (range 0.3\u201310.4\u00a0years). The odds of negative outcome between two consecutive checks significantly increased by 16% (95%CI 4\u201328%, <jats:italic>p<\/jats:italic>\u2009=\u20090.006). Taking the lowest risk group as reference, the odds ratio of negative outcome was 1.16 (95%CI 0.51\u20132.63, <jats:italic>p<\/jats:italic>\u2009=\u20090.726) for SV differences less than \u2212 37.6 \u00b5L, while it was 1.96 (95%CI 0.97\u20133.98, <jats:italic>p<\/jats:italic>\u2009=\u20090.062) for stroke volume changes above\u2009+\u200923.1 \u00b5L. Maintaining stroke volume values within a definite range might help maximize clinical benefit and avoid the risk of CSF overdrainage.<\/jats:p>","DOI":"10.1038\/s41598-021-86350-8","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T10:03:03Z","timestamp":1617012183000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Aqueductal CSF stroke volume measurements may drive management of shunted idiopathic normal pressure hydrocephalus patients"],"prefix":"10.1038","volume":"11","author":[{"given":"Antonio","family":"Scollato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Caini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Angelini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Lastrucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Di Lorenzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berardino","family":"Porfirio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Gallina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"86350_CR1","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/0022-510x(65)90016-x","volume":"2","author":"S Hakim","year":"1965","unstructured":"Hakim, S. & Adams, R. The special clinical problem of symptomatic hydrocephalus with normal cerebrospinal fluid pressure: observations on cerebrospinal fluid hydrodynamics. J. Neurol. Sci. 2, 307\u2013327. https:\/\/doi.org\/10.1016\/0022-510x(65)90016-x (1965).","journal-title":"J. Neurol. Sci."},{"key":"86350_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/2018.5.JNS173170","volume":"1","author":"J Jacobsson","year":"2018","unstructured":"Jacobsson, J., Qvarlander, S., Eklund, A. & Malm, J. Comparison of the CSF dynamics between patients with idiopathic normal pressure hydrocephalus and healthy volunteers. J. Neurosurg. 1, 1\u20136. https:\/\/doi.org\/10.3171\/2018.5.JNS173170 (2018).","journal-title":"J. Neurosurg."},{"key":"86350_CR3","doi-asserted-by":"publisher","first-page":"831","DOI":"10.3174\/ajnr.A4124","volume":"36","author":"WG Bradley Jr","year":"2015","unstructured":"Bradley, W. G. Jr. CSF flow in the brain in the context of normal pressure hydrocephalus. Am. J. 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