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Two groups were classified according to unilateral location of ischemia (distal, n\u2009=\u200910, or proximo-distal, n\u2009=\u200912). Patients described pain and three gait phases\u2014initial pain-free, onset of pain and maximum pain\u2014were analyzed. Patients with proximo-distal ischemia walked less (230\u2009\u00b1\u2009111\u00a0m vs 384\u2009\u00b1\u2009220\u00a0m), with increased step length, step time (+\u20095.4% and\u2009+\u20095.8%) and reduced cadence (\u2212\u20098.2%), than patients with distal ischemia. In both, the peaks of vertical ground reaction force were reduced in maximum pain (Peak1-distal: \u2212\u200911.4%, Peak1-proximo-distal: \u2212\u200910.3%; Peak2-distal: \u2212\u200911.8%, Peak2-proximo-distal: \u2212\u20099.0%). In the proximo-distal group, tibialis anterior activation peak and time were lower than in the distal group (\u2212\u20094.5% and \u2212\u200919.7%). During the maximum pain phase, this peak decreased only in the proximo-distal group (\u2212\u200913.0%), and gastrocnemius medialis activation peak and time decreased in both groups (\u2212\u20092.5% in distal and \u2212\u20094.5% in proximo-distal). Thus, proximo-distal ischemia leads to more adverse consequences in gait than distal ischemia only. Increasing ischemic pain until maximum, but not onset of pain, induced gait adaptations.<\/jats:p>","DOI":"10.1038\/s41598-021-86351-7","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T11:04:29Z","timestamp":1616583869000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Location of ischemia and ischemic pain intensity affect spatiotemporal parameters and leg muscles activity during walking in patients with intermittent claudication"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4038-9383","authenticated-orcid":false,"given":"C\u00e9line","family":"Guilleron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Beaune","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Pouliquen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Henni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1268-1694","authenticated-orcid":false,"given":"Sylvain","family":"Durand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"86351_CR1","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/S0140-6736(13)61249-0","volume":"382","author":"FGR Fowkes","year":"2013","unstructured":"Fowkes, F. 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