{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T18:38:27Z","timestamp":1772649507626,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007816","name":"Alcon","doi-asserted-by":"publisher","award":["61580831"],"award-info":[{"award-number":["61580831"]}],"id":[{"id":"10.13039\/100007816","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The accuracy of intraocular lens (IOL) calculations is suboptimal for long or short eyes, which results in a low visual quality after multifocal IOL implantation. The purpose of the present study is to evaluate the accuracy of IOL formulas (Barrett Universal II, SRK\/T, Holladay 1, Hoffer Q, and Haigis) for the Acrysof IQ Panoptix TFNT IOL (Alcon Laboratories, Inc, Fort Worth, Texas, United States) implantation based on the axial length (AXL) from a large cohort of 2018 cases and identify the factors that are associated with a high mean absolute error (MAE). The Barrett Universal II showed the lowest MAE in the normal AXL group (0.30\u2009\u00b1\u20090.23), whereas the Holladay 1 and Hoffer Q showed the lowest MAE in the short AXL group (0.32\u2009\u00b1\u20090.22 D and 0.32\u2009\u00b1\u20090.21 D, respectively). The Haigis showed the lowest MAE in the long AXL group (0.24\u2009\u00b1\u20090.19 D). The Barrett Universal II did not perform well in short AXL eyes with higher astigmatism (<jats:italic>P<\/jats:italic>\u2009=\u20090.013), wider white-to-white (WTW; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and shorter AXL (<jats:italic>P<\/jats:italic>\u2009=\u20090.016). Study results suggest that the Barrett Universal II performed best for the TFNT IOL in the overall study population, except for the eyes with short AXL, particularly when the eyes had higher astigmatism, wider WTW, and shorter AXL.<\/jats:p>","DOI":"10.1038\/s41598-021-86604-5","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T10:03:08Z","timestamp":1617271388000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Accuracy of theoretical IOL formulas for Panoptix intraocular lens according to axial length"],"prefix":"10.1038","volume":"11","author":[{"given":"Ayoung","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunggoo","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohee","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"key":"86604_CR1","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.jcrs.2017.06.006","volume":"43","author":"DD Koch","year":"2017","unstructured":"Koch, D. D., Hill, W., Abulafia, A. & Wang, L. Pursuing perfection in intraocular lens calculations: I. Logical approach for classifying IOL calculation formulas. J. Cataract. Refract. Surg. 43, 717\u2013718 (2017).","journal-title":"J. Cataract. Refract. Surg."},{"key":"86604_CR2","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.ophtha.2017.08.027","volume":"125","author":"RB Melles","year":"2018","unstructured":"Melles, R. B., Holladay, J. T. & Chang, W. J. Accuracy of intraocular lens calculation formulas. Ophthalmology 125, 169\u2013178 (2018).","journal-title":"Ophthalmology"},{"key":"86604_CR3","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.jcrs.2016.12.021","volume":"43","author":"JX Kane","year":"2017","unstructured":"Kane, J. X., Van Heerden, A., Atik, A. & Petsoglou, C. Accuracy of 3 new methods for intraocular lens power selection. J. Cataract. Refract. Surg. 43, 333\u2013339 (2017).","journal-title":"J. Cataract. Refract. Surg."},{"key":"86604_CR4","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.jcrs.2014.05.048","volume":"41","author":"EF Marques","year":"2015","unstructured":"Marques, E. F. & Ferreira, T. B. Comparison of visual outcomes of 2 diffractive trifocal intraocular lenses. J. Cataract. Refract. Surg. 41, 354\u2013363 (2015).","journal-title":"J. Cataract. Refract. Surg."},{"key":"86604_CR5","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ajo.2015.09.030","volume":"161","author":"T Kohnen","year":"2016","unstructured":"Kohnen, T., Titke, C. & B\u00f6hm, M. Trifocal intraocular lens implantation to treat visual demands in various distances following lens removal. Am. J. Ophthalmol. 161, 71\u20137.e1 (2016).","journal-title":"Am. J. Ophthalmol."},{"key":"86604_CR6","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40662-017-0076-8","volume":"4","author":"M Lawless","year":"2017","unstructured":"Lawless, M. et al. Visual and refractive outcomes following implantation of a new trifocal intraocular lens. Eye Vis. (Lond.) 4, 10 (2017).","journal-title":"Eye Vis. (Lond.)"},{"key":"86604_CR7","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.ajo.2017.09.016","volume":"184","author":"T Kohnen","year":"2017","unstructured":"Kohnen, T. et al. Visual performance of a quadrifocal (Trifocal) intraocular lens following removal of the crystalline lens. Am. J. Ophthalmol. 184, 52\u201362 (2017).","journal-title":"Am. J. Ophthalmol."},{"key":"86604_CR8","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.jcrs.2018.05.021","volume":"44","author":"M Shajari","year":"2018","unstructured":"Shajari, M. et al. Comparison of 9 modern intraocular lens power calculation formulas for a quadrifocal intraocular lens. J. Cataract. Refract. Surg. 44, 942\u2013948 (2018).","journal-title":"J. Cataract. Refract. Surg."},{"key":"86604_CR9","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.jcrs.2017.07.004","volume":"43","author":"SE G\u00f6kce","year":"2017","unstructured":"G\u00f6kce, S. E. et al. Intraocular lens power calculations in short eyes using 7 formulas. J. Cataract. Refract. Surg. 43, 892\u2013897 (2017).","journal-title":"J. Cataract. Refract. Surg."},{"key":"86604_CR10","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1111\/j.1755-3768.2007.00879.x","volume":"85","author":"T Olsen","year":"2007","unstructured":"Olsen, T. Calculation of intraocular lens power: a review. Acta Ophthalmol. Scand. 85, 472\u2013485 (2007).","journal-title":"Acta Ophthalmol. Scand."},{"key":"86604_CR11","doi-asserted-by":"publisher","first-page":"e0227638","DOI":"10.1371\/journal.pone.0227638","volume":"15","author":"SY Kim","year":"2020","unstructured":"Kim, S. Y., Lee, S. H., Kim, N. R., Chin, H. S. & Jung, J. W. Accuracy of intraocular lens power calculation formulas using a swept-source optical biometer. PLoS ONE 15, e0227638 (2020).","journal-title":"PLoS ONE"},{"key":"86604_CR12","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/j.jcrs.2016.06.029","volume":"42","author":"DL Cooke","year":"2016","unstructured":"Cooke, D. L. & Cooke, T. L. Comparison of 9 intraocular lens power calculation formulas. J. Cataract. Refract. Surg. 42, 1157\u20131164 (2016).","journal-title":"J. Cataract. Refract. Surg."},{"key":"86604_CR13","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jcrs.2010.07.032","volume":"37","author":"P Aristodemou","year":"2011","unstructured":"Aristodemou, P., Knox Cartwright, N. E., Sparrow, J. M. & Johnston, R. L. Formula choice: Hoffer Q, Holladay 1, or SRK\/T and refractive outcomes in 8108 eyes after cataract surgery with biometry by partial coherence interferometry. J. Cataract. Refract. Surg. 37, 63\u201371 (2011).","journal-title":"J. Cataract. Refract. Surg."},{"key":"86604_CR14","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1016\/S0161-6420(96)30558-7","volume":"103","author":"JT Holladay","year":"1996","unstructured":"Holladay, J. T., Gills, J. P., Leidlein, J. & Cherchio, M. Achieving emmetropia in extremely short eyes with two piggyback posterior chamber intraocular lenses. Ophthalmology 103, 1118\u20131123 (1996).","journal-title":"Ophthalmology"},{"key":"86604_CR15","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.jcrs.2007.10.017","volume":"34","author":"JK Wang","year":"2008","unstructured":"Wang, J. K., Hu, C. Y. & Chang, S. W. Intraocular lens power calculation using the IOLMaster and various formulas in eyes with long axial length. J. Cataract. Refract. Surg. 34, 262\u2013267 (2008).","journal-title":"J. Cataract. Refract. Surg."},{"key":"86604_CR16","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1016\/j.jcrs.2009.04.028","volume":"35","author":"K Petermeier","year":"2009","unstructured":"Petermeier, K. et al. Intraocular lens power calculation and optimized constants for highly myopic eyes. J. Cataract. Refract. Surg. 35, 1575\u20131581 (2009).","journal-title":"J. Cataract. Refract. Surg."},{"key":"86604_CR17","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/j.jcrs.2008.12.035","volume":"35","author":"W Haigis","year":"2009","unstructured":"Haigis, W. Intraocular lens calculation in extreme myopia. J. Cataract. Refract. Surg. 35, 906\u2013911 (2009).","journal-title":"J. Cataract. Refract. Surg."},{"key":"86604_CR18","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.jcrs.2017.08.003","volume":"43","author":"L Wang","year":"2017","unstructured":"Wang, L., Koch, D. D., Hill, W. & Abulafia, A. Pursuing perfection in intraocular lens calculations: III. Criteria for analyzing outcomes. J. Cataract. Refract. Surg. 43, 999\u20131002 (2017).","journal-title":"J. Cataract. Refract. Surg."},{"issue":"4","key":"86604_CR19","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3928\/1081597X-20170302-01","volume":"33","author":"DZ Reinstein","year":"2017","unstructured":"Reinstein, D. Z. et al. Standard for reporting refractive outcomes of intraocular lens-based refractive surgery. J. Refract. Surg. 33(4), 218\u2013222 (2017).","journal-title":"J. Refract. Surg."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-86604-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-86604-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-86604-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T06:19:48Z","timestamp":1670048388000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-86604-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["86604"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-86604-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,1]]},"assertion":[{"value":"5 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7346"}}