{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:52:51Z","timestamp":1789498371377,"version":"build-2803163510"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/10104-1"],"award-info":[{"award-number":["2018\/10104-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/09343-6"],"award-info":[{"award-number":["2016\/09343-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/10636-8"],"award-info":[{"award-number":["2016\/10636-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["2014\/142348-7"],"award-info":[{"award-number":["2014\/142348-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Forschungszentrum J\u00fclich GmbH"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Nitrogen fertilization has been a critical factor for high crop productivity, where urea is currently the most used N source due to its high concentration and affordability. Nevertheless, urea fast solubilization leads to frequent losses and lower agronomic efficiency. The modification of urea structure by condensation with formaldehyde has been proposed to improve nutrient uptake by plants and to reduce environmental losses. Herein we show that the co-formulation with Zn strongly modifies the N release (in lab conditions) and, more important, the Zn source\u2014ZnSO\n                    <jats:sub>4<\/jats:sub>\n                    or ZnO\u2014has a critical role. Urea\u2013formaldehyde (UF) served as a matrix for the zinc sources, and chemical characterizations revealed that Zn particles influenced the length of the polymeric chain formation. Release tests in an aqueous medium showed that the UF matrix favors ZnO release and, on the other hand, delays ZnSO\n                    <jats:sub>4<\/jats:sub>\n                    delivery. Soil incubation with the fertilizer composites proved the slow-release of N from UF, is ideal for optimizing nutritional efficiency. Our results indicated that the ZnO-UF system has beneficial effects for both nutrients, i.e., reduces N volatilization and increases Zn release.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-87112-2","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T06:12:21Z","timestamp":1617775941000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Different Zn loading in Urea\u2013Formaldehyde influences the N controlled release by structure modification"],"prefix":"10.1038","volume":"11","author":[{"given":"Amanda S.","family":"Giroto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella F.","family":"do Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gelton G. F.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai D.","family":"Jablonowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caue","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Henrique C.","family":"Mattoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"key":"87112_CR1","first-page":"813","volume":"13","author":"C Neama\u0163u","year":"2015","unstructured":"Neama\u0163u, C., Popescu, M., Oancea, F. & Dima, \u015eO. Synthesis optimization and characterization of microencapsulated N-P-K Slow-release fertilizers. Open Chem. 13, 813\u2013823 (2015).","journal-title":"Open Chem."},{"key":"87112_CR2","first-page":"2397","volume":"29","author":"W Pang","year":"2018","unstructured":"Pang, W. et al. Preparation of microcapsules of slow-release NPK compound fertilizer and the release characteristics. J. Braz. Chem. Soc. 29, 2397\u20132404 (2018).","journal-title":"J. Braz. Chem. Soc."},{"key":"87112_CR3","first-page":"1","volume":"89","author":"DRG Silva","year":"2012","unstructured":"Silva, D. R. G. & Lopes, A. S. Princ\u00edpios B\u00e1sicos Para Formula\u00e7\u00e3o E Mistura De Fertilizantes. Ed. UFLA 89, 1\u201346 (2012).","journal-title":"Ed. UFLA"},{"key":"87112_CR4","first-page":"153","volume":"49","author":"M Janmohammadi","year":"2018","unstructured":"Janmohammadi, M., Fattahi, M., Sabaghnia, N. & Nouraein, M. Effects of metal oxides and urea fertilizer on agronomic traits of safflower. Sci. Agric. Bohem. 49, 153\u2013163 (2018).","journal-title":"Sci. Agric. Bohem."},{"key":"87112_CR5","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.15376\/biores.13.1.1711-1728","volume":"13","author":"GJ Jiao","year":"2018","unstructured":"Jiao, G. J., Xu, Q., Cao, S. L., Peng, P. & She, D. Controlled-release fertilizer with lignin used to trap urea\/hydroxymethylurea\/ urea-formaldehyde polymers. BioResources 13, 1711\u20131728 (2018).","journal-title":"BioResources"},{"key":"87112_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fpls.2020.00168","volume":"11","author":"CO Dimkpa","year":"2020","unstructured":"Dimkpa, C. O. et al. Facile Coating of Urea With Low-Dose ZnO Nanoparticles promotes wheat performance and enhances Zn uptake under drought stress. Front. Plant Sci. 11, 1\u201312 (2020).","journal-title":"Front. Plant Sci."},{"key":"87112_CR7","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.cej.2015.11.023","volume":"287","author":"CF Yamamoto","year":"2016","unstructured":"Yamamoto, C. F., Pereira, E. I., Mattoso, L. H. C., Matsunaka, T. & Ribeiro, C. Slow release fertilizers based on urea\/urea-formaldehyde polymer nanocomposites. Chem. Eng. J. 287, 390\u2013397 (2016).","journal-title":"Chem. Eng. J."},{"key":"87112_CR8","doi-asserted-by":"publisher","first-page":"2448","DOI":"10.1007\/s10924-017-1141-z","volume":"26","author":"AS Giroto","year":"2018","unstructured":"Giroto, A. S. & Ribeiro, G. G. F. G. C. A. Novel, simple route to produce urea: urea \u2013 formaldehyde composites for controlled release of fertilizers. J. Polym. Environ. 26, 2448\u20132458 (2018).","journal-title":"J. Polym. Environ."},{"key":"87112_CR9","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1017\/S0021859615000441","volume":"154","author":"JX Guo","year":"2016","unstructured":"Guo, J. X. et al. Effects of soil zinc availability, nitrogen fertilizer rate and zinc fertilizer application method on zinc biofortification of rice. J. Agric. Sci. 154, 584\u2013597 (2016).","journal-title":"J. Agric. Sci."},{"key":"87112_CR10","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/j.cej.2018.11.031","volume":"359","author":"J Yang","year":"2019","unstructured":"Yang, J., Kong, X., Xu, D., Xie, W. & Wang, X. Evolution of the polydispersity of ammonium polyphosphate in a reactive extrusion process\u202f: Polycondensation mechanism and kinetics. Chem. Eng. J. 359, 1453\u20131462 (2019).","journal-title":"Chem. Eng. J."},{"key":"87112_CR11","doi-asserted-by":"publisher","first-page":"4595","DOI":"10.1021\/acs.jafc.0c00638","volume":"68","author":"W Zhang","year":"2020","unstructured":"Zhang, W. et al. Biodegradable urea-formaldehyde\/PBS and Its ternary nanocomposite prepared by a novel and scalable reactive extrusion process for slow-release applications in agriculture. J. Agric. Food Chem. 68, 4595\u20134606 (2020).","journal-title":"J. Agric. Food Chem."},{"key":"87112_CR12","unstructured":"Trenkel, M. E. Controlled-Release and Stabilized Fertilizers in Agriculture. Libro Fertilizantes (1997)."},{"key":"87112_CR13","first-page":"1","volume":"8","author":"Y Guo","year":"2018","unstructured":"Guo, Y. et al. Modeling and optimizing the synthesis of urea-formaldehyde fertilizers and analyses of factors affecting these processes. Sci. Rep. 8, 1\u20139 (2018).","journal-title":"Sci. Rep."},{"key":"87112_CR14","first-page":"1","volume":"10","author":"H Wang","year":"2018","unstructured":"Wang, H. et al. Characterization of the low molar ratio urea-formaldehyde resin with 13C NMR and ESI-MS: Negative effects of the post-added urea on the urea-formaldehyde polymers. Polymers (Basel). 10, 1 (2018).","journal-title":"Polymers (Basel)."},{"key":"87112_CR15","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1080\/01904167.2015.1106560","volume":"39","author":"P Zhao","year":"2016","unstructured":"Zhao, P., Yang, F., Sui, F., Wang, Q. & Liu, H. Effect of nitrogen fertilizers on zinc absorption and translocation in winter wheat. J. Plant Nutr. 39, 1311\u20131318 (2016).","journal-title":"J. Plant Nutr."},{"key":"87112_CR16","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.20546\/ijcmas.2017.606.225","volume":"6","author":"M Daoudi","year":"2017","unstructured":"Daoudi, M. & Singh, R. Effect of Nitrogen and Sulphur on Growth and Yield of Hybrid Maize (Zea mays L.). Int. J. Curr. Microbiol. Appl. Sci. 6, 1930\u20131935 (2017).","journal-title":"Int. J. Curr. Microbiol. Appl. Sci."},{"key":"87112_CR17","first-page":"9","volume":"03","author":"F Salehin","year":"2012","unstructured":"Salehin, F. & Rahman, S. Effects of zinc and nitrogen fertilizer and their application method on yield and yield components of Phaseolus vulgaris L. . Agric. Sci. 03, 9\u201313 (2012).","journal-title":"Agric. Sci."},{"key":"87112_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11104-007-9466-3","volume":"302","author":"I Cakmak","year":"2008","unstructured":"Cakmak, I. Enrichment of cereal grains with zinc: Agronomic or genetic biofortification?. Plant Soil 302, 1\u201317 (2008).","journal-title":"Plant Soil"},{"key":"87112_CR19","doi-asserted-by":"publisher","first-page":"5760","DOI":"10.1021\/jf030092m","volume":"51","author":"JM Alvarez","year":"2003","unstructured":"Alvarez, J. M. & Rico, M. I. Effects of zinc complexes on the distribution of zinc in calcareous soil and zinc uptake by maize. J. Agric. Food Chem. 51, 5760\u20135767 (2003).","journal-title":"J. Agric. Food Chem."},{"key":"87112_CR20","doi-asserted-by":"publisher","first-page":"5068","DOI":"10.1021\/acs.jafc.0c00084","volume":"68","author":"H Sun","year":"2020","unstructured":"Sun, H. et al. Development of ZnO Nanoparticles as an Efficient Zn Fertilizer: Using Synchrotron-Based Techniques and Laser Ablation to Examine Elemental Distribution in Wheat Grain. J. Agric. Food Chem. 68, 5068\u20135075 (2020).","journal-title":"J. Agric. Food Chem."},{"key":"87112_CR21","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1080\/01904167.2018.1454957","volume":"41","author":"M Irfan","year":"2018","unstructured":"Irfan, M., Khan Niazi, M. B., Hussain, A., Farooq, W. & Zia, M. H. Synthesis and characterization of zinc-coated urea fertilizer. J. Plant Nutr. 41, 1625\u20131635 (2018).","journal-title":"J. Plant Nutr."},{"key":"87112_CR22","doi-asserted-by":"publisher","first-page":"9993","DOI":"10.1021\/acssuschemeng.7b01919","volume":"5","author":"EI Pereira","year":"2017","unstructured":"Pereira, E. I. et al. Controlled urea release employing nanocomposites increases the efficiency of nitrogen use by forage. ACS Sustain. Chem. Eng. 5, 9993\u201310001 (2017).","journal-title":"ACS Sustain. Chem. Eng."},{"key":"87112_CR23","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1007\/s11696-017-0245-1","volume":"71","author":"M Gonz\u00e1lez-Hurtado","year":"2017","unstructured":"Gonz\u00e1lez-Hurtado, M., Rieumont-Briones, J., Castro-Gonz\u00e1lez, L. M., Zumeta-Dube, I. & Galano, A. Combined experimental-theoretical investigation on the interactions of Diuron with a urea-formaldehyde matrix: Implications for its use as an \u2018intelligent pesticide\u2019. Chem. Pap. 71, 2495\u20132503 (2017).","journal-title":"Chem. Pap."},{"key":"87112_CR24","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s10973-007-8731-2","volume":"92","author":"T Zorba","year":"2008","unstructured":"Zorba, T., Papadopoulou, E., Hatjiissaak, A., Paraskevopoulos, K. M. & Chrissafis, K. Urea-formaldehyde resins characterized by thermal analysis and FTIR method. J. Therm. Anal. Calorim. 92, 29\u201333 (2008).","journal-title":"J. Therm. Anal. Calorim."},{"key":"87112_CR25","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1590\/S0100-40422002000500003","volume":"25","author":"EdC Mattos","year":"2002","unstructured":"Mattos, Ed. C., Vigan\u00f3, I., Dutra, R. D. C. L., Diniz, M. F. & Iha, K. Aplica\u00e7\u00e3o de metodologias FTIR de transmiss\u00e3o e fotoac\u00fastica \u00e0 caracteriza\u00e7\u00e3o de materiais altamente energ\u00e9ticos: parte II. Quim. Nova 25, 722\u2013728 (2002).","journal-title":"Quim. Nova"},{"key":"87112_CR26","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1002\/app.1988.070350614","volume":"35","author":"SS Jada","year":"1988","unstructured":"Jada, S. S. The structure of urea\u2014formaldehyde resins. J. Appl. Polym. Sci. 35, 1573\u20131592 (1988).","journal-title":"J. Appl. Polym. Sci."},{"key":"87112_CR27","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1002\/app.23782","volume":"100","author":"P Christjanson","year":"2006","unstructured":"Christjanson, P., Pehk, T. & Siimer, K. Hydroxymethylation and polycondensation reactions in urea-formaldehyde resin synthesis. J. Appl. Polym. Sci. 100, 1673\u20131680 (2006).","journal-title":"J. Appl. Polym. Sci."},{"key":"87112_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ma11061032","volume":"11","author":"P Pereira","year":"2018","unstructured":"Pereira, P. et al. Copolymerization of UF resins with dimethylurea for improving storage stability without impairing adhesive performance. Materials (Basel). 11, 1 (2018).","journal-title":"Materials (Basel)."},{"key":"87112_CR29","doi-asserted-by":"publisher","first-page":"13095","DOI":"10.1021\/acs.iecr.0c02268","volume":"59","author":"ES Wibowo","year":"2020","unstructured":"Wibowo, E. S., Park, B. D. & Causin, V. Hydrogen-bond-induced crystallization in low-molar-ratio urea-formaldehyde resins during synthesis. Ind. Eng. Chem. Res. 59, 13095\u201313104 (2020).","journal-title":"Ind. Eng. Chem. Res."},{"key":"87112_CR30","doi-asserted-by":"publisher","first-page":"7606","DOI":"10.1021\/acs.jafc.8b02349","volume":"66","author":"Y Xiang","year":"2018","unstructured":"Xiang, Y. et al. Granular, slow-release fertilizer from urea-formaldehyde, ammonium polyphosphate, and amorphous silica gel: a new strategy using cold extrusion. J. Agric. Food Chem. 66, 7606\u20137615 (2018).","journal-title":"J. Agric. Food Chem."},{"key":"87112_CR31","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1080\/01694243.2015.1067176","volume":"29","author":"P Qu","year":"2015","unstructured":"Qu, P., Huang, H., Wu, G., Sun, E. & Chang, Z. Hydrolyzed soy protein isolates modified urea-formaldehyde resins as adhesives and its biodegradability. J. Adhes. Sci. Technol. 29, 2381\u20132398 (2015).","journal-title":"J. Adhes. Sci. Technol."},{"key":"87112_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijadhadh.2019.102440","volume":"95","author":"M Khonakdar Dazmiri","year":"2019","unstructured":"Khonakdar Dazmiri, M., Valizadeh Kiamahalleh, M., Dorieh, A. & Pizzi, A. Effect of the initial F\/U molar ratio in urea-formaldehyde resins synthesis and its influence on the performance of medium density fiberboard bonded with them. Int. J. Adhes. Adhes. 95, 1 (2019).","journal-title":"Int. J. Adhes. Adhes."},{"key":"87112_CR33","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/apmc.1976.050540114","volume":"54","author":"W Dankelman","year":"1976","unstructured":"Dankelman, W. et al. Modern methods for the analysis of urea formaldehyde resins. Die Angew. Makromol. Chemie 54, 187\u2013201 (1976).","journal-title":"Die Angew. Makromol. Chemie"},{"key":"87112_CR34","doi-asserted-by":"publisher","first-page":"104179","DOI":"10.1039\/C5RA17669G","volume":"5","author":"AS Giroto","year":"2015","unstructured":"Giroto, A. S., Fid\u00e9lis, S. C. & Ribeiro, C. Controlled release from hydroxyapatite nanoparticles incorporated into biodegradable, soluble host matrixes. RSC Adv. 5, 104179\u2013104186 (2015).","journal-title":"RSC Adv."},{"key":"87112_CR35","doi-asserted-by":"publisher","first-page":"46032","DOI":"10.1038\/srep46032","volume":"7","author":"AS Giroto","year":"2017","unstructured":"Giroto, A. S., Guimar\u00e3es, G. G. F., Foschini, M. & Ribeiro, C. Role of slow-release nanocomposite fertilizers on nitrogen and phosphate availability in soil. Sci. Rep. 7, 46032 (2017).","journal-title":"Sci. Rep."},{"key":"87112_CR36","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1002\/jpln.201500622","volume":"179","author":"GGF Guimar\u00e3es","year":"2016","unstructured":"Guimar\u00e3es, G. G. F., Mulvaney, R. L., Khan, S. A., Cantarutti, R. B. & Silva, A. M. Comparison of urease inhibitor N-(n-butyl) thiophosphoric triamide and oxidized charcoal for conserving urea-N in soil. J. Plant Nutr. Soil Sci. 179, 520\u2013528 (2016).","journal-title":"J. Plant Nutr. Soil Sci."},{"key":"87112_CR37","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.jclepro.2019.01.275","volume":"217","author":"AS Giroto","year":"2019","unstructured":"Giroto, A. S. et al. Controlled release of nitrogen using urea-melamine-starch composites. J. Clean. Prod. 217, 448\u2013455 (2019).","journal-title":"J. Clean. Prod."},{"key":"87112_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/1678-992x-2018-0033","volume":"77","author":"R Bortoletto-Santos","year":"2020","unstructured":"Bortoletto-Santos, R. et al. Biodegradable oil-based polymeric coatings on urea fertilizer: N release kinetic transformations of urea in soil. Sci. Agric. 77, 1\u20139 (2020).","journal-title":"Sci. Agric."},{"key":"87112_CR39","doi-asserted-by":"publisher","first-page":"4634","DOI":"10.1021\/jf0116808","volume":"50","author":"M Tomaszewska","year":"2002","unstructured":"Tomaszewska, M. & Jarosiewicz, A. Use of polysulfone in controlled-release NPK fertilizer formulations. J. Agric. Food Chem. 50, 4634\u20134639 (2002).","journal-title":"J. Agric. Food Chem."},{"key":"87112_CR40","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/00010694-194907000-00003","volume":"68","author":"VJ Kilmer","year":"1949","unstructured":"Kilmer, V. J. & Alexander, L. T. Methods of making mechanical analyses of soils. Soil Sci. 68, 15\u201324 (1949).","journal-title":"Soil Sci."},{"key":"87112_CR41","unstructured":"Embrapa. Documentos 132 Manual de M\u00e9todos de. Embrapa 230 (2011)."},{"key":"87112_CR42","unstructured":"Nelson, D. W. Chapter 34 Total Carbon , Organic Carbon , and Organic Matter. 53711 (1996)."},{"key":"87112_CR43","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/0038-0717(71)90039-3","volume":"3","author":"JM Bremner","year":"1971","unstructured":"Bremner, J. M. & Douglas, L. A. Inhibition of urease activity in soils. Soil Biol. Biochem. 3, 297\u2013307 (1971).","journal-title":"Soil Biol. Biochem."},{"key":"87112_CR44","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1080\/00103628609367745","volume":"17","author":"AJ Kempers","year":"1986","unstructured":"Kempers, A. J. & Zweers, A. Ammonium determination in soil extracts by the salicylate method. Commun. Soil Sci. Plant Anal. 17, 715\u2013723 (1986).","journal-title":"Commun. Soil Sci. Plant Anal."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-87112-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-87112-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-87112-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T01:15:45Z","timestamp":1670030145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-87112-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,7]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["87112"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-87112-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-211210\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,7]]},"assertion":[{"value":"5 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7621"}}