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Eighty women under the age of 35 were divided into two groups: 1\u2014POR without using plastic containers (n\u2009=\u200940) and 2\u2014POR with using plastic containers (n\u2009=\u200940). The ICAM-1 and HLA-G genes and protein expressions were examined by the quantitative PCR and western blotting technique. The methylation pattern was investigated by the methylation-specific PCR. Total BPA in follicular fluid was measured with high-performance liquid chromatography technique and the detection limit was 1.14\u00a0ng\/ml. ICAM-1 and HLA-G genes were differentially expressed between the two groups studied. ICAM-1, HLA-G genes, and protein expressions in group 1 were up-regulated compared to the second group (P\u2009&lt;\u20090.05). While DNA methylation status in group 1 were decreased compared to the other group (P\u2009&lt;\u20090.05). The concentration of BPA in the follicular fluid of group 1 was lower compared to the second group (P\u2009&lt;\u20090.05). The oocyte quality and clinical pregnancy ratio showed significantly higher in group 1 than in the other ones (P\u2009&lt;\u20090.05). The alteration of ICAM-1 and HLA-G gene expressions in POR women is probably related to BPA concentration. As a result Lifestyle habits may also affect the methylation pattern and protein levels in the cumulus cells of POR women. Additionally, lifestyle habits may be considered as a marker for ovulation, oocyte maturation, preimplantation, and clinical pregnancy process.<\/jats:p>","DOI":"10.1038\/s41598-021-87175-1","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T10:07:04Z","timestamp":1620209224000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of bisphenol A on alterations of ICAM-1 and HLA-G genes expression and DNA methylation profiles in cumulus cells of infertile women with poor response to ovarian stimulation"],"prefix":"10.1038","volume":"11","author":[{"given":"Somayeh","family":"Aftabsavad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Noormohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Moini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Karimipoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"87175_CR1","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1093\/humrep\/der092","volume":"26","author":"A-P Ferraretti","year":"2011","unstructured":"Ferraretti, A.-P. et al. 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