{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:11:01Z","timestamp":1766362261621,"version":"3.37.3"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Guadalajara: Programa para el desarrollo Profesional Docente.","award":["UDG-PTC-1294"],"award-info":[{"award-number":["UDG-PTC-1294"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adipokines, especially chemerin, can interact with cytokines and other molecules in inflammation. To date, there is insufficient information regarding a possible correlation between functional disability and chemerin and other pro-inflammatory molecules in rheumatoid arthritis (RA). To identify the association of functional disability with serum chemerin and other pro-inflammatory molecules, including other adipokines, cytokines and E-selectin, in patients with RA. Cross-sectional study. Assessment: disease activity (DAS28-ESR) and functional disability (HAQ-DI). We compared the adipokines (chemerin, leptin, adiponectin, resistin, and visfatin), cytokines (TNF-\u03b1, IL-6, IL-1\u03b2, and IL-18) and E-selectin levels between RA with functional disability and RA non-disabled patients. Of 82 patients with RA, 43 (52%) had functional disability. The RA with functional disability group had higher chemerin (140 vs. 112\u00a0ng\/mL, p\u2009=\u20090.007) than the non-disabled RA group. Chemerin correlated with the HAQ-DI (rho\u2009=\u20090.27, p\u2009=\u20090.02) and DAS28-ESR (rho\u2009=\u20090.21, p\u2009=\u20090.05). Severe activity correlated with IL-6 (rho\u2009=\u20090.33, p\u2009=\u20090.003) and E-selectin (rho\u2009=\u20090.23, p\u2009=\u20090.03) but not with disability. No other pro-inflammatory molecules correlated with HAQ-DI. High chemerin levels were associated with functional disability in RA, whereas no other molecules correlated with loss of function. These results encourage further studies assessing new roles of chemerin as a marker of impairment in RA.<\/jats:p>","DOI":"10.1038\/s41598-021-87235-6","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T11:36:09Z","timestamp":1618572969000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Functional disability is related to serum chemerin levels in rheumatoid arthritis"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1399-270X","authenticated-orcid":false,"given":"Maria Luisa","family":"Vazquez-Villegas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0001-3787","authenticated-orcid":false,"given":"Jorge I.","family":"Gamez-Nava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2272-9612","authenticated-orcid":false,"given":"A. Miriam","family":"Salda\u00f1a-Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3527-0428","authenticated-orcid":false,"given":"Alfredo","family":"Celis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9474-1824","authenticated-orcid":false,"given":"Esther N.","family":"Sanchez-Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0007-1824","authenticated-orcid":false,"given":"Edsaul Emilio","family":"Perez-Guerrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5975-8532","authenticated-orcid":false,"given":"Melissa","family":"Ramirez-Villafa\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3562-7033","authenticated-orcid":false,"given":"Cesar Arturo","family":"Nava-Valdivia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6665-3950","authenticated-orcid":false,"given":"Betsabe","family":"Contreras-Haro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7426-0639","authenticated-orcid":false,"given":"Jose C.","family":"Vasquez-Jimenez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5035-3347","authenticated-orcid":false,"given":"Juan M.","family":"Ponce-Guarneros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-5437","authenticated-orcid":false,"given":"Ana K.","family":"Barocio-Ramirez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0755-0289","authenticated-orcid":false,"given":"Sergio","family":"Cerpa-Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6441-8997","authenticated-orcid":false,"given":"Miriam F.","family":"Alcaraz-Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-6344","authenticated-orcid":false,"given":"Laura","family":"Gonzalez-Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"issue":"10055","key":"87235_CR1","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","volume":"388","author":"JS Smolen","year":"2016","unstructured":"Smolen, J. S., Aletaha, D. & McInnes, I. B. Rheumatoid arthritis. Lancet 388(10055), 2023\u20132038 (2016).","journal-title":"Lancet"},{"issue":"10086","key":"87235_CR2","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1016\/S0140-6736(17)31472-1","volume":"389","author":"IB McInnes","year":"2017","unstructured":"McInnes, I. B. & Schett, G. Pathogenetic insights from the treatment of rheumatoid arthritis. Lancet 389(10086), 2328\u20132337 (2017).","journal-title":"Lancet"},{"issue":"1","key":"87235_CR3","doi-asserted-by":"publisher","first-page":"R56","DOI":"10.1186\/ar4491","volume":"16","author":"H Radner","year":"2014","unstructured":"Radner, H., Smolen, J. S. & Aletaha, D. Remission in rheumatoid arthritis: benefit over low disease activity in patient-reported outcomes and costs. Arthritis Res. Ther. 16(1), R56 (2014).","journal-title":"Arthritis Res. Ther."},{"doi-asserted-by":"crossref","unstructured":"Mc Donald, I.J., Liu, S.C., Huang, C.C., Kuo, S.J., Tsai, C.H. & Tang, C.H. Associations between adipokines in arthritic disease and implications for obesity. Int. J. Mol. Sci. 20(6), E1505 (2019).","key":"87235_CR4","DOI":"10.3390\/ijms20061505"},{"issue":"7","key":"87235_CR5","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1002\/art.24626","volume":"60","author":"YH Rho","year":"2009","unstructured":"Rho, Y. H. et al. Adipocytokines are associated with radiographic joint damage in rheumatoid arthritis. Arthritis Rheum. 60(7), 1906\u20131914 (2009).","journal-title":"Arthritis Rheum."},{"issue":"2","key":"87235_CR6","doi-asserted-by":"publisher","first-page":"191","DOI":"10.5114\/aoms.2013.33181","volume":"9","author":"M Coelho","year":"2013","unstructured":"Coelho, M., Oliveira, T. & Fernandes, R. Biochemistry of adipose tissue: An endocrine organ. Arch. Med. Sci. 9(2), 191\u2013200 (2013).","journal-title":"Arch. Med. Sci."},{"issue":"9","key":"87235_CR7","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1136\/ard.2005.046540","volume":"65","author":"M Otero","year":"2006","unstructured":"Otero, M. et al. Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann. Rheum. Dis. 65(9), 1198\u20131201 (2006).","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"87235_CR8","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1007\/s00296-009-1053-x","volume":"30","author":"B Targo\u0144ska-Stepniak","year":"2010","unstructured":"Targo\u0144ska-Stepniak, B., Dryglewska, M. & Majdan, M. Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis. Rheumatol. Int. 30(6), 731\u2013737 (2010).","journal-title":"Rheumatol. Int."},{"issue":"4","key":"87235_CR9","doi-asserted-by":"publisher","first-page":"269","DOI":"10.2169\/internalmedicine.50.4306","volume":"50","author":"T Yoshino","year":"2011","unstructured":"Yoshino, T. et al. Elevated serum levels of resistin, leptin, and adiponectin are associated with C-reactive protein and also other clinical conditions in rheumatoid arthritis. Intern. Med. 50(4), 269\u2013275 (2011).","journal-title":"Intern. Med."},{"issue":"2","key":"87235_CR10","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.jbspin.2013.07.013","volume":"81","author":"YJ Ha","year":"2014","unstructured":"Ha, Y. J. et al. Plasma chemerin levels in rheumatoid arthritis are correlated with disease activity rather than obesity. Joint Bone Spine 81(2), 189\u2013190 (2014).","journal-title":"Joint Bone Spine"},{"doi-asserted-by":"crossref","unstructured":"Tolusso, B. et al. Chemerin and PEDF are metaflammation-related biomarkers of disease activity and obesity in rheumatoid arthritis. Front. Med. (Lausanne). 5, 207 (2018).","key":"87235_CR11","DOI":"10.3389\/fmed.2018.00207"},{"issue":"5","key":"87235_CR12","doi-asserted-by":"publisher","first-page":"R158","DOI":"10.1186\/ar3475","volume":"13","author":"K Kaneko","year":"2011","unstructured":"Kaneko, K. et al. Chemerin activates fibroblast-like synoviocytes in patients with rheumatoid arthritis. Arthritis Res. Ther. 13(5), R158 (2011).","journal-title":"Arthritis Res. Ther."},{"issue":"3","key":"87235_CR13","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s10067-014-2704-1","volume":"34","author":"K Makrilakis","year":"2015","unstructured":"Makrilakis, K., Fragiadaki, K., Smith, J., Sfikakis, P. P. & Kitas, G. D. Interrelated reduction of chemerin and plasminogen activator inhibitor-1 serum levels in rheumatoid arthritis after interleukin-6 receptor blockade. Clin. Rheumatol. 34(3), 419\u2013427 (2015).","journal-title":"Clin. Rheumatol."},{"issue":"3","key":"87235_CR14","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1097\/01.bor.0000218948.42730.39","volume":"18","author":"SK Agarwal","year":"2006","unstructured":"Agarwal, S. K. & Brenner, M. B. Role of adhesion molecules in synovial inflammation. Curr. Opin. Rheumatol. 18(3), 268\u2013276 (2006).","journal-title":"Curr. Opin. Rheumatol."},{"issue":"2","key":"87235_CR15","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1111\/imcb.12208","volume":"97","author":"B Zimmermann-Geller","year":"2019","unstructured":"Zimmermann-Geller, B. et al. Interactions between rheumatoid arthritis synovial fibroblast migration and endothelial cells. Immunol. Cell Biol. 97(2), 178\u2013189 (2019).","journal-title":"Immunol. Cell Biol."},{"issue":"3","key":"87235_CR16","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s00296-008-0688-3","volume":"29","author":"EG Corona-Sanchez","year":"2009","unstructured":"Corona-Sanchez, E. G. et al. Circulating E-selectin and tumor necrosis factor-alpha in extraarticular involvement and joint disease activity in rheumatoid arthritis. Rheumatol. Int. 29(3), 281\u2013286 (2009).","journal-title":"Rheumatol. Int."},{"issue":"3","key":"87235_CR17","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1136\/ard.61.3.242","volume":"61","author":"A Kuuliala","year":"2002","unstructured":"Kuuliala, A. et al. Circulating soluble E-selectin in early rheumatoid arthritis: A prospective five-year study. Ann. Rheum. Dis. 61(3), 242\u2013246 (2002).","journal-title":"Ann. Rheum. Dis."},{"key":"87235_CR18","doi-asserted-by":"publisher","first-page":"925","DOI":"10.3389\/fimmu.2020.00925","volume":"11","author":"R Hasseli","year":"2020","unstructured":"Hasseli, R. et al. Adipokines and inflammation alter the interaction between rheumatoid arthritis synovial fibroblasts and endothelial cells. Front. Immunol. 11, 925 (2020).","journal-title":"Front. Immunol."},{"issue":"5\u20136","key":"87235_CR19","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.cytogfr.2011.11.004","volume":"2","author":"B Bondue","year":"2011","unstructured":"Bondue, B., Wittamer, V. & Parmentier, M. Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism. Cytokine Growth Factor Rev. 2(5\u20136), 331\u2013338 (2011).","journal-title":"Cytokine Growth Factor Rev."},{"issue":"2","key":"87235_CR20","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/ar3273","volume":"13","author":"F Iannone","year":"2011","unstructured":"Iannone, F. & Lapadula, G. Chemerin\/ChemR23 pathway: A system beyond chemokines. Arthritis Res. Ther. 13(2), 104 (2011).","journal-title":"Arthritis Res. Ther."},{"issue":"2","key":"87235_CR21","first-page":"243","volume":"32","author":"E Valcamonica","year":"2014","unstructured":"Valcamonica, E. et al. Levels of chemerin and interleukin 8 in the synovial fluid of patients with inflammatory arthritides and osteoarthritis. Clin. Exp. Rheumatol. 32(2), 243\u2013250 (2014).","journal-title":"Clin. Exp. Rheumatol."},{"issue":"17","key":"87235_CR22","doi-asserted-by":"publisher","first-page":"E4091","DOI":"10.3390\/ijms20174091","volume":"20","author":"M Carrion","year":"2019","unstructured":"Carrion, M. et al. The adipokine network in rheumatic joint diseases. Int. J. Mol. Sci. 20(17), E4091 (2019).","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"87235_CR23","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1084\/jem.20030382","volume":"198","author":"V Wittamer","year":"2003","unstructured":"Wittamer, V. et al. Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. J. Exp. Med. 198(7), 977\u2013985 (2003).","journal-title":"J. Exp. Med."},{"issue":"9","key":"87235_CR24","doi-asserted-by":"publisher","first-page":"3625","DOI":"10.1182\/blood-2006-08-038844","volume":"109","author":"S Parolini","year":"2007","unstructured":"Parolini, S. et al. The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues. Blood 109(9), 3625\u20133632 (2007).","journal-title":"Blood"},{"issue":"3","key":"87235_CR25","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/S0014-5793(03)01312-7","volume":"555","author":"W Meder","year":"2003","unstructured":"Meder, W. et al. Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23. FEBS Lett. 555(3), 495\u2013499 (2003).","journal-title":"FEBS Lett."},{"issue":"6","key":"87235_CR26","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1210\/en.2009-0794","volume":"151","author":"SD Parlee","year":"2010","unstructured":"Parlee, S. D., Ernst, M. C., Muruganandan, S., Sinal, C. J. & Goralski, K. B. Serum chemerin levels vary with time of day and are modified by obesity and tumor necrosis factor-\u03b1. Endocrinology 151(6), 2590\u20132602 (2010).","journal-title":"Endocrinology"},{"issue":"2","key":"87235_CR27","first-page":"293","volume":"37","author":"A Fioravanti","year":"2019","unstructured":"Fioravanti, A. et al. Tocilizumab modulates serum levels of adiponectin and chemerin in patients with rheumatoid arthritis: Potential cardiovascular protective role of IL-6 inhibition. Clin. Exp. Rheumatol. 37(2), 293\u2013300 (2019).","journal-title":"Clin. Exp. Rheumatol."},{"issue":"2","key":"87235_CR28","first-page":"117","volume":"11","author":"MH Cardiel","year":"1993","unstructured":"Cardiel, M. H., Abello-Banfi, M., Ruiz-Mercado, R. & Alarcon-Segovia, D. How to measure health status in rheumatoid arthritis in non-English speaking patients: Validation of a Spanish version of the Health Assessment Questionnaire. Clin. Exp. Rheumatol. 11(2), 117\u2013121 (1993).","journal-title":"Clin. Exp. Rheumatol."},{"doi-asserted-by":"crossref","unstructured":"van Gestel, A.M., Prevoo, M.L., van 't Hof, M.A., van Rijswijk, M.H., van de Putte, L.B. & van Riel, P.L. Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis. Comparison with the preliminary American College of Rheumatology and the World Health Organization\/International League Against Rheumatism Criteria. Arthritis Rheum. 39(1), 34-4 (1996).","key":"87235_CR29","DOI":"10.1002\/art.1780390105"},{"issue":"8","key":"87235_CR30","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1001\/jama.1949.02900430001001","volume":"140","author":"O Steinbrocker","year":"1949","unstructured":"Steinbrocker, O., Traeger, C. H. & Batterman, R. C. Therapeutic criteria in rheumatoid arthritis. J. Am. Med. Assoc. 140(8), 659\u2013662 (1949).","journal-title":"J. Am. Med. Assoc."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-87235-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-87235-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-87235-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T06:48:53Z","timestamp":1670050133000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-87235-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,16]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["87235"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-87235-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2021,4,16]]},"assertion":[{"value":"30 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8360"}}