{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T16:23:38Z","timestamp":1793982218002,"version":"4.8.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005902","name":"D\u00e9l\u00e9gation G\u00e9n\u00e9rale pour l'Armement","doi-asserted-by":"publisher","award":["SAN-1-516"],"award-info":[{"award-number":["SAN-1-516"]}],"id":[{"id":"10.13039\/501100005902","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>On one side, decompression sickness (DCS) with neurological disorders lead to a reshuffle of the fecal metabolome from rat caecum. On the other side, there is high inter-individual variability in terms of occurrence of DCS. One could wonder whether the fecal metabolome could be linked to the DCS-susceptibility. We decided to study male and female rats selected for their resistance to decompression sickness, and we hypothesize a strong impregnation concerning the fecal metabolome. The aim is to verify whether the rats resistant to the accident have a fecal metabolomic signature different from the stem generations sensitive to DCS. 39 DCS-resistant animals (21 females and 18 males), aged 14\u00a0weeks, were compared to 18 age-matched standard Wistar rats (10 females and 8 males), i.e., the same as those we used for the founding stock. Conventional and ChemRICH approaches helped the metabolomic interpretation of the 226 chemical compounds analyzed in the cecal content. Statistical analysis shows a panel of 81 compounds whose expression had changed following the selection of rats based on their resistance to DCS. 63 compounds are sex related. 39 are in common. This study shows the spectral fingerprint of the fecal metabolome from the caecum of a strain of rats resistant to decompression sickness. This study also confirms a difference linked to sex in the metabolome of non-selected rats, which disappear with selective breeding. Results suggest hormonal and energetic reshuffle, including steroids sugars or antibiotic compounds, whether in the host or in the microbial community.<\/jats:p>","DOI":"10.1038\/s41598-021-87952-y","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T10:18:05Z","timestamp":1618481885000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evidence of a hormonal reshuffle in the cecal metabolome fingerprint of a strain of rats resistant to decompression sickness"],"prefix":"10.1038","volume":"11","author":[{"given":"Nicolas","family":"Vallee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Dugrenot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Virginie","family":"Desruelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Tardivel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Charles","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Guernec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Boussuges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Rives","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Risso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"87952_CR1","unstructured":"Bert, P. Barometric pressure (La pression barom\u00e9trique). Bethesda, MD: Undersea Medical Society; translated by Hitchcok, MA. and Hitchcok, FA in 1978 (1978)."},{"key":"87952_CR2","first-page":"373","volume":"18","author":"KD Sawatzky","year":"1991","unstructured":"Sawatzky, K. D. & Nishi, R. Y. Assessment of inter-rater agreement on the grading of intravascular bubble signals. Undersea Biomed. Res. 18, 373\u2013396 (1991).","journal-title":"Undersea Biomed. Res."},{"key":"87952_CR3","volume-title":"Bennett and Elliott\u2019s Physiology and Medicine of Diving","author":"A Brubakk","year":"2003","unstructured":"Brubakk, A. & Neumann, T. Bennett and Elliott\u2019s Physiology and Medicine of Diving 5th edn. (Saunders, 2003).","edition":"5"},{"key":"87952_CR4","unstructured":"Ardestani, S. B., Buzzacott, P. & Eftedal, I. The aging diver: endothelial biochemistry and its potential implications for cardiovascular health. (2015)."},{"key":"87952_CR5","first-page":"118","volume":"37","author":"NW Pollock","year":"2007","unstructured":"Pollock, N. W. Aerobic fitness and underwater diving. Div. Hyperb. Med. S. Pac. Underw. Med. Soc. 37, 118 (2007).","journal-title":"Div. Hyperb. Med. S. Pac. Underw. Med. Soc."},{"key":"87952_CR6","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.jjcc.2019.04.014","volume":"74","author":"J Hon\u011bk","year":"2019","unstructured":"Hon\u011bk, J. et al. High-grade patent foramen ovale is a risk factor of unprovoked decompression sickness in recreational divers. J. Cardiol. 74, 519\u2013523 (2019).","journal-title":"J. Cardiol."},{"key":"87952_CR7","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.compbiomed.2014.10.012","volume":"55","author":"P Buzzacott","year":"2014","unstructured":"Buzzacott, P. et al. A ternary model of decompression sickness in rats. Comput. Biol. Med. 55, 74\u201378 (2014).","journal-title":"Comput. Biol. Med."},{"key":"87952_CR8","first-page":"93","volume":"30","author":"M Hagberg","year":"2003","unstructured":"Hagberg, M. & Ornhagen, H. Incidence and risk factors for symptoms of decompression sickness among male and female dive masters and instructors\u2013a retrospective cohort study. Undersea Hyperb. Med. 30, 93\u2013102 (2003).","journal-title":"Undersea Hyperb. Med."},{"key":"87952_CR9","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1249\/MSS.0000000000001385","volume":"49","author":"J Lautridou","year":"2017","unstructured":"Lautridou, J. et al. Evidence of heritable determinants of decompression sickness in rats. Med. Sci. Sports Exerc. 49, 2433\u20132438. https:\/\/doi.org\/10.1249\/MSS.0000000000001385 (2017).","journal-title":"Med. Sci. Sports Exerc."},{"key":"87952_CR10","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1152\/japplphysiol.00324.2020","volume":"129","author":"J Lautridou","year":"2020","unstructured":"Lautridou, J. et al. Physiological characteristics associated with increased resistance to decompression sickness in male and female rats. J. Appl. Physiol. 129, 612\u2013625 (2020).","journal-title":"J. Appl. Physiol."},{"key":"87952_CR11","doi-asserted-by":"publisher","first-page":"e00826","DOI":"10.1128\/AEM.00826-19","volume":"85","author":"H Korach-Rechtman","year":"2019","unstructured":"Korach-Rechtman, H. et al. Murine genetic background has a stronger impact on the composition of the gut microbiota than maternal inoculation or exposure to unlike exogenous microbiota. Appl. Environ. Microbiol. 85, e00826-e1819 (2019).","journal-title":"Appl. Environ. Microbiol."},{"key":"87952_CR12","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.jnutbio.2015.08.013","volume":"28","author":"P Ojeda","year":"2016","unstructured":"Ojeda, P., Bobe, A., Dolan, K., Leone, V. & Martinez, K. Nutritional modulation of gut microbiota\u2014the impact on metabolic disease pathophysiology. J. Nutr. Biochem. 28, 191\u2013200 (2016).","journal-title":"J. Nutr. Biochem."},{"key":"87952_CR13","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/ismej.2012.153","volume":"7","author":"N Fei","year":"2013","unstructured":"Fei, N. & Zhao, L. An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice. ISME J. 7, 880\u2013884 (2013).","journal-title":"ISME J."},{"key":"87952_CR14","doi-asserted-by":"publisher","first-page":"415","DOI":"10.3390\/biology9120415","volume":"9","author":"A Ballini","year":"2020","unstructured":"Ballini, A., Scacco, S., Boccellino, M., Santacroce, L. & Arrigoni, R. Microbiota and obesity: where are we now?. Biology 9, 415 (2020).","journal-title":"Biology"},{"key":"87952_CR15","first-page":"89","volume":"28","author":"SR Kayar","year":"2001","unstructured":"Kayar, S. R. & Fahlman, A. Decompression sickness risk reduced by native intestinal flora in pigs after H2 dives. Undersea Hyperb. Med. 28, 89\u201397 (2001).","journal-title":"Undersea Hyperb. Med."},{"issue":"91","key":"87952_CR16","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1152\/jappl.2001.91.6.2713","volume":"1985","author":"SR Kayar","year":"2001","unstructured":"Kayar, S. R., Fahlman, A., Lin, W. C. & Whitman, W. B. Increasing activity of H(2)-metabolizing microbes lowers decompression sickness risk in pigs during H(2) dives. J. Appl. Physiol. 1985(91), 2713\u20132719. https:\/\/doi.org\/10.1152\/jappl.2001.91.6.2713 (2001).","journal-title":"J. Appl. Physiol."},{"key":"87952_CR17","first-page":"R677","volume":"275","author":"SR Kayar","year":"1998","unstructured":"Kayar, S. R. et al. Decompression sickness risk in rats by microbial removal of dissolved gas. Am. J. Physiol. 275, R677-682 (1998).","journal-title":"Am. J. Physiol."},{"key":"87952_CR18","doi-asserted-by":"publisher","first-page":"10128","DOI":"10.1038\/s41598-018-28510-x","volume":"8","author":"S de Maistre","year":"2018","unstructured":"de Maistre, S., Vallee, N., Gaillard, S., Duchamp, C. & Blatteau, J. E. Stimulating fermentation by the prolonged acceleration of gut transit protects against decompression sickness. Sci. Rep. 8, 10128. https:\/\/doi.org\/10.1038\/s41598-018-28510-x (2018).","journal-title":"Sci. Rep."},{"key":"87952_CR19","doi-asserted-by":"publisher","first-page":"20379","DOI":"10.1038\/srep20379","volume":"6","author":"S de Maistre","year":"2016","unstructured":"de Maistre, S. et al. Colonic fermentation promotes decompression sickness in rats. Sci. Rep. 6, 20379. https:\/\/doi.org\/10.1038\/srep20379 (2016).","journal-title":"Sci. Rep."},{"issue":"121","key":"87952_CR20","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1152\/japplphysiol.00503.2016","volume":"1985","author":"S de Maistre","year":"2016","unstructured":"de Maistre, S. et al. Gut fermentation seems to promote decompression sickness in humans. J. Appl. Physiol. 1985(121), 973\u2013979. https:\/\/doi.org\/10.1152\/japplphysiol.00503.2016 (2016).","journal-title":"J. Appl. Physiol."},{"key":"87952_CR21","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1152\/physiolgenomics.00164.2012","volume":"45","author":"I Eftedal","year":"2013","unstructured":"Eftedal, I. et al. Acute and potentially persistent effects of scuba diving on the blood transcriptome of experienced divers. Physiol. Genom. 45, 965\u2013972. https:\/\/doi.org\/10.1152\/physiolgenomics.00164.2012 (2013).","journal-title":"Physiol. Genom."},{"issue":"108","key":"87952_CR22","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1152\/japplphysiol.00596.2009","volume":"1985","author":"EA Montcalm-Smith","year":"2010","unstructured":"Montcalm-Smith, E. A. et al. Acclimation to decompression sickness in rats. J. Appl. Physiol. 1985(108), 596\u2013603. https:\/\/doi.org\/10.1152\/japplphysiol.00596.2009 (2010).","journal-title":"J. Appl. Physiol."},{"key":"87952_CR23","doi-asserted-by":"publisher","first-page":"15996","DOI":"10.1038\/s41598-020-73033-z","volume":"10","author":"S de Maistre","year":"2020","unstructured":"de Maistre, S. et al. Cecal metabolome fingerprint in a rat model of decompression sickness with neurological disorders. Sci. Rep. 10, 15996. https:\/\/doi.org\/10.1038\/s41598-020-73033-z (2020).","journal-title":"Sci. Rep."},{"key":"87952_CR24","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1080\/15287394.2019.1625474","volume":"82","author":"C Rosique","year":"2019","unstructured":"Rosique, C. et al. Assessment of the effects of repeated doses of potassium iodide intake during pregnancy on male and female rat offspring using metabolomics and lipidomics. J. Toxicol. Environ. Health A 82, 603\u2013615. https:\/\/doi.org\/10.1080\/15287394.2019.1625474 (2019).","journal-title":"J. Toxicol. Environ. Health A"},{"key":"87952_CR25","doi-asserted-by":"publisher","first-page":"5132","DOI":"10.1021\/pr900499r","volume":"8","author":"FM Van Der Kloet","year":"2009","unstructured":"Van Der Kloet, F. M., Bobeldijk, I., Verheij, E. R. & Jellema, R. H. Analytical error reduction using single point calibration for accurate and precise metabolomic phenotyping. J. Proteome Res. 8, 5132\u20135141 (2009).","journal-title":"J. Proteome Res."},{"key":"87952_CR26","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1093\/bioinformatics\/btu813","volume":"31","author":"F Giacomoni","year":"2015","unstructured":"Giacomoni, F. et al. Workflow4Metabolomics: a collaborative research infrastructure for computational metabolomics. Bioinformatics 31, 1493\u20131495 (2015).","journal-title":"Bioinformatics"},{"key":"87952_CR27","doi-asserted-by":"publisher","first-page":"14567","DOI":"10.1038\/s41598-017-15231-w","volume":"7","author":"DK Barupal","year":"2017","unstructured":"Barupal, D. K. & Fiehn, O. Chemical similarity enrichment analysis (ChemRICH) as alternative to biochemical pathway mapping for metabolomic datasets. Sci. Rep. 7, 14567. https:\/\/doi.org\/10.1038\/s41598-017-15231-w (2017).","journal-title":"Sci. Rep."},{"key":"87952_CR28","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1533\/9781845695743.3.211","volume-title":"in Endocrine-Disrupting Chemicals in Food","author":"B Thomson","year":"2009","unstructured":"Thomson, B. in Endocrine-Disrupting Chemicals in Food 211\u2013258 (Elsevier, London, 2009)."},{"key":"87952_CR29","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/B978-0-12-801238-3.64414-8","volume-title":"in Encyclopedia of Reproduction","author":"R Barakat","year":"2018","unstructured":"Barakat, R., Park, C. J., Perez, P. A., Chiu, K. & Ko, C. M. in Encyclopedia of Reproduction 740\u2013747 (Elsevier, 2018)."},{"key":"87952_CR30","volume-title":"Flaxseed","author":"D Morris","year":"2003","unstructured":"Morris, D. & Vaisey-Genser, M. Flaxseed (Elsevier, 2003)."},{"key":"87952_CR31","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/B978-1-891127-65-6.50012-X","volume-title":"Durum Wheat","author":"C Grant","year":"2012","unstructured":"Grant, C., Cubadda, F., Carcea, M., Pogna, N. E. & Gazza, L. Durum Wheat 125\u2013137 (Elsevier, Amsterdam, 2012)."},{"key":"87952_CR32","first-page":"964","volume":"14","author":"BC Schulte","year":"2015","unstructured":"Schulte, B. C., Wu, W. & Rosen, T. Azelaic acid: evidence-based update on mechanism of action and clinical application. J. Drugs Dermatol. 14, 964\u2013968 (2015).","journal-title":"J. Drugs Dermatol."},{"key":"87952_CR33","doi-asserted-by":"publisher","first-page":"17R","DOI":"10.1093\/glycob\/cwg047","volume":"13","author":"AD Elbein","year":"2003","unstructured":"Elbein, A. D., Pan, Y., Pastuszak, I. & Carroll, D. New insights on trehalose: a multifunctional molecule. Glycobiology 13, 17R-27R (2003).","journal-title":"Glycobiology"},{"key":"87952_CR34","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1146\/annurev.arplant.50.1.473","volume":"50","author":"KM Herrmann","year":"1999","unstructured":"Herrmann, K. M. & Weaver, L. M. The shikimate pathway. Annu. Rev. Plant Biol. 50, 473\u2013503 (1999).","journal-title":"Annu. Rev. Plant Biol."},{"key":"87952_CR35","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.phrs.2013.01.003","volume":"69","author":"A-M Davila","year":"2013","unstructured":"Davila, A.-M. et al. Re-print of \u201cIntestinal luminal nitrogen metabolism: role of the gut microbiota and consequences for the host\u201d. Pharmacol. Res. 69, 114\u2013126 (2013).","journal-title":"Pharmacol. Res."},{"key":"87952_CR36","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s40168-019-0699-1","volume":"7","author":"F Li","year":"2019","unstructured":"Li, F. et al. Host genetics influence the rumen microbiota and heritable rumen microbial features associate with feed efficiency in cattle. Microbiome 7, 92 (2019).","journal-title":"Microbiome"},{"key":"87952_CR37","doi-asserted-by":"publisher","DOI":"10.1128\/mSystems.00387-19","author":"L Cao","year":"2019","unstructured":"Cao, L., Shcherbin, E. & Mohimani, H. A metabolome- and metagenome-wide association network reveals microbial natural products and microbial biotransformation products from the human microbiota. mSystems https:\/\/doi.org\/10.1128\/mSystems.00387-19 (2019).","journal-title":"mSystems"},{"key":"87952_CR38","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1021\/bi5000564","volume":"53","author":"KJ Aldred","year":"2014","unstructured":"Aldred, K. J., Kerns, R. J. & Osheroff, N. Mechanism of quinolone action and resistance. Biochemistry 53, 1565\u20131574. https:\/\/doi.org\/10.1021\/bi5000564 (2014).","journal-title":"Biochemistry"},{"key":"87952_CR39","first-page":"2132","volume":"26","author":"A Nostro","year":"2012","unstructured":"Nostro, A. et al. Antimicrobial activity and phenolic content of natural site and micropropagated Limonium avei (De Not.) Brullo & Erben plant extracts. Nat. Prod. Res. 26, 2132\u20132136 (2012).","journal-title":"Nat. Prod. Res."},{"key":"87952_CR40","doi-asserted-by":"publisher","first-page":"77","DOI":"10.17306\/J.AFS.2015.1.9","volume":"14","author":"MA Stachelska","year":"2015","unstructured":"Stachelska, M. A. Inhibitory properties of lithium, sodium and potassium o-, m-and p-coumarates against Escherichia coli O157: H7. Acta Sci. Pol. Technol. Aliment. 14, 77\u201384 (2015).","journal-title":"Acta Sci. Pol. Technol. Aliment."},{"key":"87952_CR41","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1159\/000501396","volume":"91","author":"WL Miller","year":"2019","unstructured":"Miller, W. L. Congenital adrenal hyperplasia: time to replace 17OHP with 21-deoxycortisol. Horm. Res. Paediatr. 91, 416\u2013420 (2019).","journal-title":"Horm. Res. Paediatr."},{"key":"87952_CR42","unstructured":"PubChem. PubChem Compound Summary for CID 440707, Cortodoxone. Retrieved September 14, 2020., https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Cortodoxone (2020)."},{"key":"87952_CR43","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1093\/jxb\/ert457","volume":"65","author":"UP Yadav","year":"2014","unstructured":"Yadav, U. P. et al. The sucrose\u2013trehalose 6-phosphate (Tre6P) nexus: specificity and mechanisms of sucrose signalling by Tre6P. J. Exp. Bot. 65, 1051\u20131068 (2014).","journal-title":"J. Exp. Bot."},{"key":"87952_CR44","doi-asserted-by":"publisher","first-page":"101479","DOI":"10.1016\/j.isci.2020.101479","volume":"23","author":"S Ohno","year":"2020","unstructured":"Ohno, S. et al. Kinetic trans-omic analysis reveals key regulatory mechanisms for insulin-regulated glucose metabolism in adipocytes. iScience 23, 101479 (2020).","journal-title":"iScience"},{"key":"87952_CR45","doi-asserted-by":"publisher","first-page":"504","DOI":"10.3390\/nu11030504","volume":"11","author":"PC Bradshaw","year":"2019","unstructured":"Bradshaw, P. C. Cytoplasmic and mitochondrial NADPH-coupled redox systems in the regulation of aging. Nutrients 11, 504 (2019).","journal-title":"Nutrients"},{"key":"87952_CR46","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.cmet.2016.07.024","volume":"24","author":"G Rey","year":"2016","unstructured":"Rey, G. et al. The pentose phosphate pathway regulates the circadian clock. Cell Metab. 24, 462\u2013473 (2016).","journal-title":"Cell Metab."},{"key":"87952_CR47","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1158\/1541-7786.MCR-13-0258-T","volume":"12","author":"AA Parkhitko","year":"2014","unstructured":"Parkhitko, A. A. et al. Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. Mol. Cancer Res. 12, 48\u201357 (2014).","journal-title":"Mol. Cancer Res."},{"key":"87952_CR48","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/0014-5793(70)80063-1","volume":"6","author":"E K\u00f6hler","year":"1970","unstructured":"K\u00f6hler, E., Barrach, H.-J. & Neubert, D. Inhibition of NADP dependent oxidoreductases by the 6-aminonicotinamide analogue of NADP. FEBS Lett. 6, 225\u2013228 (1970).","journal-title":"FEBS Lett."},{"key":"87952_CR49","doi-asserted-by":"publisher","first-page":"H709","DOI":"10.1152\/ajpheart.00783.2013","volume":"306","author":"C Vimercati","year":"2014","unstructured":"Vimercati, C. et al. Beneficial effects of acute inhibition of the oxidative pentose phosphate pathway in the failing heart. Am. J. Physiol. Heart Circ. Physiol. 306, H709\u2013H717 (2014).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"87952_CR50","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.3389\/fphys.2018.01695","volume":"9","author":"JE Blatteau","year":"2018","unstructured":"Blatteau, J. E. et al. Reduction in the level of plasma mitochondrial DNA in human diving, followed by an increase in the event of an accident. Front. Physiol. 9, 1695. https:\/\/doi.org\/10.3389\/fphys.2018.01695 (2018).","journal-title":"Front. Physiol."},{"key":"87952_CR51","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1152\/japplphysiol.91004.2008","volume":"106","author":"SR Thom","year":"2009","unstructured":"Thom, S. R. Oxidative stress is fundamental to hyperbaric oxygen therapy. J. Appl. Physiol. 106, 988\u2013995 (2009).","journal-title":"J. Appl. Physiol."},{"key":"87952_CR52","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/j.1748-1716.2010.02247.x","volume":"202","author":"C Morabito","year":"2011","unstructured":"Morabito, C. et al. Effect of pre-breathing oxygen at different depth on oxidative status and calcium concentration in lymphocytes of scuba divers. Acta Physiol. 202, 69\u201378 (2011).","journal-title":"Acta Physiol."},{"key":"87952_CR53","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1249\/MSS.0000000000000563","volume":"47","author":"Q Wang","year":"2015","unstructured":"Wang, Q. et al. Reactive oxygen species, mitochondria, and endothelial cell death during in vitro simulated dives. Med. Sci. Sports Exerc. 47, 1362\u20131371. https:\/\/doi.org\/10.1249\/MSS.0000000000000563 (2015).","journal-title":"Med. Sci. Sports Exerc."},{"key":"87952_CR54","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1093\/jxb\/err275","volume":"63","author":"AA Badejo","year":"2012","unstructured":"Badejo, A. A. et al. Translocation and the alternative D-galacturonate pathway contribute to increasing the ascorbate level in ripening tomato fruits together with the D-mannose\/L-galactose pathway. J. Exp. Bot. 63, 229\u2013239 (2012).","journal-title":"J. Exp. Bot."},{"key":"87952_CR55","first-page":"1","volume":"20","author":"L Xu","year":"2020","unstructured":"Xu, L., Yang, Y. & Chen, J. The role of reactive oxygen species in cognitive impairment associated with sleep apnea. Exp. Ther. Med. 20, 1\u20131 (2020).","journal-title":"Exp. Ther. Med."},{"key":"87952_CR56","doi-asserted-by":"publisher","first-page":"15076","DOI":"10.1038\/s41598-020-72054-y","volume":"10","author":"AHA Hassan","year":"2020","unstructured":"Hassan, A. H. A. et al. Heat stress as an innovative approach to enhance the antioxidant production in Pseudooceanicola and Bacillus isolates. Sci. Rep. 10, 15076. https:\/\/doi.org\/10.1038\/s41598-020-72054-y (2020).","journal-title":"Sci. Rep."},{"key":"87952_CR57","doi-asserted-by":"publisher","first-page":"111339","DOI":"10.1016\/j.colsurfb.2020.111339","volume":"196","author":"F Paulo","year":"2020","unstructured":"Paulo, F. & Santos, L. New insights in the in vitro release of phenolic antioxidants: the case study of the release behavior of tyrosol from tyrosol-loaded ethylcellulose microparticles during the in vitro gastrointestinal digestion. Coll. Surf. B Biointerfaces 196, 111339 (2020).","journal-title":"Coll. Surf. B Biointerfaces"},{"key":"87952_CR58","doi-asserted-by":"publisher","first-page":"106904","DOI":"10.1016\/j.intimp.2020.106904","volume":"88","author":"W Qi","year":"2020","unstructured":"Qi, W. et al. Upregulation of Sirt1 by tyrosol suppresses apoptosis and inflammation and modulates extracellular matrix remodeling in interleukin-1\u03b2-stimulated human nucleus pulposus cells through activation of PI3K\/Akt pathway. Int. Immunopharmacol. 88, 106904 (2020).","journal-title":"Int. Immunopharmacol."},{"key":"87952_CR59","first-page":"77","volume":"33","author":"XW Dong","year":"2020","unstructured":"Dong, X. W. et al. Urine Metabonomic analysis of interventions effect of soy isoflavones on rats exposed to di-(2-ethylhexyl) phthalate. Biomed. Environ. Sci. 33, 77\u201388 (2020).","journal-title":"Biomed. Environ. Sci."},{"key":"87952_CR60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-56847-4","volume":"10","author":"Y Chen","year":"2020","unstructured":"Chen, Y., Wang, J., Yu, L., Xu, T. & Zhu, N. Microbiota and metabolome responses in the cecum and serum of broiler chickens fed with plant essential oils or virginiamycin. Sci. Rep. 10, 1\u201314 (2020).","journal-title":"Sci. Rep."},{"key":"87952_CR61","doi-asserted-by":"publisher","first-page":"4523","DOI":"10.1073\/pnas.1006734107","volume":"108","author":"JR Swann","year":"2011","unstructured":"Swann, J. R. et al. Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. Proc. Natl. Acad. Sci. 108, 4523\u20134530 (2011).","journal-title":"Proc. Natl. Acad. Sci."},{"key":"87952_CR62","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/nrgastro.2013.105","volume":"10","author":"G Mawe","year":"2013","unstructured":"Mawe, G. & Hoffman, J. Serotonin signaling in the gastrointestinal tract. Nat. Rev. Gastroenterol. Hepatol. 10, 473\u2013486 (2013).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"87952_CR63","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.bbr.2014.07.027","volume":"277","author":"SM O\u2019Mahony","year":"2015","unstructured":"O\u2019Mahony, S. M., Clarke, G., Borre, Y., Dinan, T. & Cryan, J. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav. Brain Res. 277, 32\u201348 (2015).","journal-title":"Behav. Brain Res."},{"key":"87952_CR64","first-page":"17","volume":"10","author":"C Alpert","year":"2008","unstructured":"Alpert, C., Sczesny, S., Gruhl, B. & Blaut, M. Long-term stability of the human gut microbiota in two different rat strains. Curr. Issues Mol. Biol. 10, 17 (2008).","journal-title":"Curr. Issues Mol. Biol."},{"key":"87952_CR65","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1093\/advances\/nmaa085","volume":"12","author":"K Albracht-Schulte","year":"2021","unstructured":"Albracht-Schulte, K., Islam, T., Johnson, P. & Moustaid-Moussa, N. Systematic review of beef protein effects on gut microbiota: implications for health. Adv. Nutr. 12, 102\u2013114 (2021).","journal-title":"Adv. Nutr."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-87952-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-87952-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-87952-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T06:31:21Z","timestamp":1675146681000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-87952-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,15]]},"references-count":65,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["87952"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-87952-y","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,15]]},"assertion":[{"value":"14 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8317"}}