{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:54:37Z","timestamp":1783468477734,"version":"3.55.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["285933818"],"award-info":[{"award-number":["285933818"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Charit\u00e9"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The actin binding protein drebrin plays a key role in dendritic spine formation and synaptic plasticity. Decreased drebrin protein levels have been observed in temporal lobe epilepsy, suggesting the involvement of drebrin in the disease. Here we investigated the effect of drebrin knockout on physiological and pathophysiological neuronal network activities in mice by inducing gamma oscillations, involved in higher cognitive functions, and by analyzing pathophysiological epileptiform activity. We found that loss of drebrin increased the emergence of spontaneous gamma oscillations suggesting an increase in neuronal excitability when drebrin is absent. Further analysis showed that although the kainate-induced hippocampal gamma oscillations were unchanged in drebrin deficient mice, seizure like events measured in the entorhinal cortex appeared earlier and more frequently. The results suggest that while drebrin is not essential for normal\u00a0physiological network activity, it helps to protect against the formation of seizure like activities during pathological conditions. The data indicate that targeting drebrin function could potentially be a preventive or therapeutic strategy for epilepsy treatment.<\/jats:p>","DOI":"10.1038\/s41598-021-87967-5","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T10:44:41Z","timestamp":1619001881000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex"],"prefix":"10.1038","volume":"11","author":[{"given":"Alexander","family":"Klemz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Kreis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta J.","family":"Eickholt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan","family":"Gerevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"87967_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrdp.2018.24","volume":"4","author":"O Devinsky","year":"2018","unstructured":"Devinsky, O. et al. Epilepsy. Nat. Rev. Dis. Primers. 4, 1\u201324. https:\/\/doi.org\/10.1038\/nrdp.2018.24 (2018).","journal-title":"Nat. Rev. Dis. Primers."},{"key":"87967_CR2","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/S1474-4422(04)00906-8","volume":"3","author":"CE Elger","year":"2004","unstructured":"Elger, C. E., Helmstaedter, C. & Kurthen, M. Chronic epilepsy and cognition. Lancet Neurol. 3, 663\u2013672. https:\/\/doi.org\/10.1016\/S1474-4422(04)00906-8 (2004).","journal-title":"Lancet Neurol."},{"key":"87967_CR3","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1586\/14737175.8.6.907","volume":"8","author":"M Wong","year":"2008","unstructured":"Wong, M. Stabilizing dendritic structure as a novel therapeutic approach for epilepsy. Expert Rev. Neurother. 8, 907\u2013915. https:\/\/doi.org\/10.1586\/14737175.8.6.907 (2008).","journal-title":"Expert Rev. Neurother."},{"key":"87967_CR4","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0165-0270(94)00125-Z","volume":"57","author":"PV Belichenko","year":"1995","unstructured":"Belichenko, P. V. & Dahlstr\u00f6m, A. Studies on the 3-dimensional architecture of dendritic spines and varicosities in human cortex by confocal laser scanning microscopy and Lucifer Yellow microinjections. J. Neurosci. Methods 57, 55\u201361. https:\/\/doi.org\/10.1016\/0165-0270(94)00125-Z (1995).","journal-title":"J. Neurosci. Methods"},{"key":"87967_CR5","doi-asserted-by":"publisher","first-page":"8356","DOI":"10.1523\/JNEUROSCI.18-20-08356.1998","volume":"18","author":"M Jiang","year":"1998","unstructured":"Jiang, M., Lee, C. L., Smith, K. L. & Swann, J. W. Spine loss and other persistent alterations of hippocampal pyramidal cell dendrites in a model of early-onset epilepsy. J. Neurosci. 18, 8356\u20138368. https:\/\/doi.org\/10.1523\/JNEUROSCI.18-20-08356.1998 (1998).","journal-title":"J. Neurosci."},{"key":"87967_CR6","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1111\/j.1528-1157.1994.tb02503.x","volume":"35","author":"P Multani","year":"1994","unstructured":"Multani, P., Myers, R. H., Blume, H. W., Schomer, D. L. & Sotrel, A. Neocortical dendritic pathology in human partial epilepsy: A quantitative golgi study. Epilepsia 35, 728\u2013736. https:\/\/doi.org\/10.1111\/j.1528-1157.1994.tb02503.x (1994).","journal-title":"Epilepsia"},{"key":"87967_CR7","doi-asserted-by":"publisher","first-page":"19926","DOI":"10.1074\/jbc.M113.472647","volume":"288","author":"MA Mikati","year":"2013","unstructured":"Mikati, M. A., Grintsevich, E. E. & Reisler, E. Drebrin-induced stabilization of actin filaments. J. Biol. Chem. 288, 19926\u201319938. https:\/\/doi.org\/10.1074\/jbc.M113.472647 (2013).","journal-title":"J. Biol. Chem."},{"key":"87967_CR8","doi-asserted-by":"publisher","first-page":"6586","DOI":"10.1523\/JNEUROSCI.23-16-06586.2003","volume":"23","author":"H Takahashi","year":"2003","unstructured":"Takahashi, H. et al. Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis. J. Neurosci. 23, 6586\u20136595. https:\/\/doi.org\/10.1523\/JNEUROSCI.23-16-06586.2003 (2003).","journal-title":"J. Neurosci."},{"key":"87967_CR9","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1111\/j.1471-4159.2005.03536.x","volume":"97","author":"H Takahashi","year":"2006","unstructured":"Takahashi, H., Mizui, T. & Shirao, T. Down-regulation of drebrin A expression suppresses synaptic targeting of NMDA receptors in developing hippocampal neurones. J. Neurochem. 97, 110\u2013115. https:\/\/doi.org\/10.1111\/j.1471-4159.2005.03536.x (2006).","journal-title":"J. Neurochem."},{"key":"87967_CR10","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1242\/jcs.033464","volume":"122","author":"A Ivanov","year":"2009","unstructured":"Ivanov, A., Esclapez, M., Pellegrino, C., Shirao, T. & Ferhat, L. Drebrin A regulates dendritic spine plasticity and synaptic function in mature cultured hippocampal neurons. J. Cell Sci. 122, 524\u2013534. https:\/\/doi.org\/10.1242\/jcs.033464 (2009).","journal-title":"J. Cell Sci."},{"key":"87967_CR11","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/jnc.13119","volume":"134","author":"G Jung","year":"2015","unstructured":"Jung, G. et al. Drebrin depletion alters neurotransmitter receptor levels in protein complexes, dendritic spine morphogenesis and memory-related synaptic plasticity in the mouse hippocampus. J. Neurochem. 134, 327\u2013339. https:\/\/doi.org\/10.1111\/jnc.13119 (2015).","journal-title":"J. Neurochem."},{"key":"87967_CR12","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.neuroscience.2009.10.016","volume":"165","author":"N Kojima","year":"2010","unstructured":"Kojima, N. et al. Genetic disruption of the alternative splicing of drebrin gene impairs context-dependent fear learning in adulthood. Neuroscience 165, 138\u2013150. https:\/\/doi.org\/10.1016\/j.neuroscience.2009.10.016 (2010).","journal-title":"Neuroscience"},{"key":"87967_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep42652","volume":"7","author":"CG Willmes","year":"2017","unstructured":"Willmes, C. G. et al. Investigation of hippocampal synaptic transmission and plasticity in mice deficient in the actin-binding protein Drebrin. Sci. Rep. 7, 1\u201311. https:\/\/doi.org\/10.1038\/srep42652 (2017).","journal-title":"Sci. Rep."},{"key":"87967_CR14","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.neuroscience.2012.03.048","volume":"251","author":"M Wong","year":"2013","unstructured":"Wong, M. & Guo, D. Dendritic spine pathology in epilepsy: Cause or consequence?. Neuroscience 251, 141\u2013150. https:\/\/doi.org\/10.1016\/j.neuroscience.2012.03.048 (2013).","journal-title":"Neuroscience"},{"key":"87967_CR15","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1002\/jnr.490430111","volume":"43","author":"Y Harigaya","year":"1996","unstructured":"Harigaya, Y., Shoji, M., Shirao, T. & Hirai, S. Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer\u2019s disease. J. Neurosci. Res. 43, 87\u201392. https:\/\/doi.org\/10.1002\/jnr.490430111 (1996).","journal-title":"J. Neurosci. Res."},{"key":"87967_CR16","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/BF00688755","volume":"50","author":"M Suetsugu","year":"1980","unstructured":"Suetsugu, M. & Mehraein, P. Spine distribution along the apical dendrites of the pyramidal neurons in Down\u2019s syndrome\u2014A quantitative golgi study. Acta Neuropathol. 50, 207\u2013210. https:\/\/doi.org\/10.1007\/BF00688755 (1980).","journal-title":"Acta Neuropathol."},{"key":"87967_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/epi.16595","volume":"00","author":"TC Dombroski","year":"2020","unstructured":"Dombroski, T. C. et al. Drebrin expression patterns in patients with refractory temporal lobe epilepsy and hippocampal sclerosis. Epilepsia 00, 1\u201314. https:\/\/doi.org\/10.1111\/epi.16595 (2020).","journal-title":"Epilepsia"},{"key":"87967_CR18","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1002\/hipo.20914","volume":"22","author":"O Sbai","year":"2012","unstructured":"Sbai, O., Khrestchatisky, M., Esclapez, M. & Ferhat, L. Drebrin A expression is altered after pilocarpine-induced seizures: Time course of changes is consistent for a role in the integrity and stability of dendritic spines of hippocampal granule cells. Hippocampus 22, 477\u2013493. https:\/\/doi.org\/10.1002\/hipo.20914 (2012).","journal-title":"Hippocampus"},{"key":"87967_CR19","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1155\/2012\/474351","volume":"1\u201312","author":"L Ferhat","year":"2012","unstructured":"Ferhat, L. Potential role of drebrin A, an F-actin binding protein, in reactive synaptic plasticity after pilocarpine-induced seizures: Functional implications in epilepsy. Int. J. Cell Biol. 1\u201312, 2012. https:\/\/doi.org\/10.1155\/2012\/474351 (2012).","journal-title":"Int. J. Cell Biol."},{"key":"87967_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1523\/ENEURO.0088-15.2016","volume":"3","author":"J Seinfeld","year":"2016","unstructured":"Seinfeld, J., Baudry, N., Xu, X., Bi, X. & Baudry, M. Differential activation of calpain-1 and calpain-2 following kainate-induced seizure activity in rats and mice. eNeuro 3, 1\u201312. https:\/\/doi.org\/10.1523\/ENEURO.0088-15.2016 (2016).","journal-title":"eNeuro"},{"key":"87967_CR21","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1146\/annurev-neuro-062111-150444","volume":"35","author":"G Buzs\u00e1ki","year":"2012","unstructured":"Buzs\u00e1ki, G. & Wang, X.-J. Mechanisms of gamma oscillations. Annu. Rev. Neurosci. 35, 203\u2013225. https:\/\/doi.org\/10.1146\/annurev-neuro-062111-150444 (2012).","journal-title":"Annu. Rev. Neurosci."},{"key":"87967_CR22","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1111\/ejn.12606","volume":"39","author":"CA Bosman","year":"2014","unstructured":"Bosman, C. A., Lansink, C. S. & Pennartz, C. M. A. Functions of gamma-band synchronization in cognition: From single circuits to functional diversity across cortical and subcortical systems. Eur. J. Neurosci. 39, 1982\u20131999. https:\/\/doi.org\/10.1111\/ejn.12606 (2014).","journal-title":"Eur. J. Neurosci."},{"key":"87967_CR23","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1152\/jn.1987.57.3.869","volume":"57","author":"I Mody","year":"1987","unstructured":"Mody, I., Lambert, J. D. & Heinemann, U. Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices. J. Neurophysiol. 57, 869\u2013888. https:\/\/doi.org\/10.1152\/jn.1987.57.3.869 (1987).","journal-title":"J. Neurophysiol."},{"key":"87967_CR24","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/BF00227083","volume":"87","author":"JP Dreier","year":"1991","unstructured":"Dreier, J. P. & Heinemann, U. Regional and time dependent variations of low Mg 2+ induced epileptiform activity in rat temporal cortex slices. Exp. Brain Res. 87, 581\u2013596. https:\/\/doi.org\/10.1007\/BF00227083 (1991).","journal-title":"Exp. Brain Res."},{"key":"87967_CR25","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1146\/annurev.neuro.051508.135603","volume":"32","author":"P Fries","year":"2009","unstructured":"Fries, P. Neuronal gamma-band synchronization as a fundamental process in cortical computation. Annu. Rev. Neurosci. 32, 209\u2013224. https:\/\/doi.org\/10.1146\/annurev.neuro.051508.135603 (2009).","journal-title":"Annu. Rev. Neurosci."},{"key":"87967_CR26","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1016\/j.neuroscience.2010.06.043","volume":"169","author":"K Hanamura","year":"2010","unstructured":"Hanamura, K. et al. Low accumulation of drebrin at glutamatergic postsynaptic sites on GABAergic neurons. Neuroscience 169, 1489\u20131500. https:\/\/doi.org\/10.1016\/j.neuroscience.2010.06.043 (2010).","journal-title":"Neuroscience"},{"key":"87967_CR27","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/hipo.20508","volume":"19","author":"AM W\u00f3jtowicz","year":"2009","unstructured":"W\u00f3jtowicz, A. M. et al. Monoamines block kainate- and carbachol-induced \u03b3-oscillations but augment stimulus-induced \u03b3-oscillations in rat hippocampus in vitro. Hippocampus 19, 273\u2013288. https:\/\/doi.org\/10.1002\/hipo.20508 (2009).","journal-title":"Hippocampus"},{"key":"87967_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0071957","volume":"8","author":"P Kreis","year":"2013","unstructured":"Kreis, P. et al. Phosphorylation of the actin binding protein drebrin at S647 is regulated by neuronal activity and PTEN. PLoS ONE 8, 1\u201312. https:\/\/doi.org\/10.1371\/journal.pone.0071957 (2013).","journal-title":"PLoS ONE"},{"key":"87967_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-019-08420-w","volume":"10","author":"P Kreis","year":"2019","unstructured":"Kreis, P. et al. ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans. Nat. Commun. 10, 1\u201313. https:\/\/doi.org\/10.1038\/s41467-019-08420-w (2019).","journal-title":"Nat. Commun."},{"key":"87967_CR30","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/0920-1211(93)90043-7","volume":"14","author":"J Bear","year":"1993","unstructured":"Bear, J. & Lothman, E. W. An in vitro study of focal epileptogenesis in combined hippocampal-parahippocampal slices. Epilepsy Res. 14, 183\u2013193. https:\/\/doi.org\/10.1016\/0920-1211(93)90043-7 (1993).","journal-title":"Epilepsy Res."},{"key":"87967_CR31","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0920-1211(98)00050-3(Elsevier","volume":"32","author":"T Gloveli","year":"1998","unstructured":"Gloveli, T., Schmitz, D. & Heinemann, U. Interaction between superficial layers of the entorhinal cortex and the hippocampus in normal and epileptic temporal lobe. Epilepsy Res. 32, 183\u2013193. https:\/\/doi.org\/10.1016\/S0920-1211(98)00050-3(Elsevier (1998).","journal-title":"Epilepsy Res."},{"key":"87967_CR32","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fncir.2015.00027","volume":"9","author":"MS Vismer","year":"2015","unstructured":"Vismer, M. S., Forcelli, P. A., Skopin, M. D., Gale, K. & Koubeissi, M. Z. The piriform, perirhinal, and entorhinal cortex in seizure generation. Front. Neural Circ. 9, 27. https:\/\/doi.org\/10.3389\/fncir.2015.00027 (2015).","journal-title":"Front. Neural Circ."},{"key":"87967_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2056","author":"CA Schevon","year":"2012","unstructured":"Schevon, C. A. et al. Evidence of an inhibitory restraint of seizure activity in humans. Nat. Commun. https:\/\/doi.org\/10.1038\/ncomms2056 (2012).","journal-title":"Nat. Commun."},{"key":"87967_CR34","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1002\/ana.25720","volume":"87","author":"J Pitsch","year":"2020","unstructured":"Pitsch, J. et al. Drebrin autoantibodies in patients with seizures and suspected encephalitis. Ann. Neurol. 87, 869\u2013884. https:\/\/doi.org\/10.1002\/ana.25720 (2020).","journal-title":"Ann. Neurol."},{"key":"87967_CR35","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1111\/j.1528-1167.2006.00554.x","volume":"47","author":"JC Amatniek","year":"2006","unstructured":"Amatniek, J. C. et al. Incidence and predictors of seizures in patients with Alzheimer\u2019s disease. Epilepsia 47, 867\u2013872. https:\/\/doi.org\/10.1111\/j.1528-1167.2006.00554.x (2006).","journal-title":"Epilepsia"},{"key":"87967_CR36","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1002\/mds.25237","volume":"27","author":"LJ Cloud","year":"2012","unstructured":"Cloud, L. J. et al. Seizures in juvenile Huntington\u2019s disease: Frequency and characterization in a multicenter cohort. Mov. Disord. 27, 1797\u20131800. https:\/\/doi.org\/10.1002\/mds.25237 (2012).","journal-title":"Mov. Disord."},{"key":"87967_CR37","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1097\/00001756-199407000-00025","volume":"5","author":"PV Belichenko","year":"1994","unstructured":"Belichenko, P. V., Oldfors, A., Hagberg, B. & Dahlstr\u00f6m, A. Rett syndrome: 3-D confocal microscopy of cortical pyramidal dendrites and afferents. NeuroReport 5, 1509\u20131513. https:\/\/doi.org\/10.1097\/00001756-199407000-00025 (1994).","journal-title":"NeuroReport"},{"key":"87967_CR38","first-page":"52","volume":"3","author":"JP Machado-Salas","year":"1984","unstructured":"Machado-Salas, J. P. Abnormal dendritic patterns and aberrant spine development in Bourneville\u2019s disease\u2013a Golgi survey. Clin. Neuropathol. 3, 52\u201358 (1984).","journal-title":"Clin. Neuropathol."},{"key":"87967_CR39","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/ajmg.1320410306","volume":"41","author":"VJ Hinton","year":"1991","unstructured":"Hinton, V. J., Brown, W. T., Wisniewski, K. & Rudelli, R. D. Analysis of neocortex in three males with the fragile X syndrome. Am. J. Med. Genet. 41, 289\u2013294. https:\/\/doi.org\/10.1002\/ajmg.1320410306 (1991).","journal-title":"Am. J. Med. Genet."},{"key":"87967_CR40","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.neuron.2014.03.021","volume":"82","author":"M Bosch","year":"2014","unstructured":"Bosch, M. et al. Structural and molecular remodeling of dendritic spine substructures during long-term potentiation. Neuron 82, 444\u2013459. https:\/\/doi.org\/10.1016\/j.neuron.2014.03.021 (2014).","journal-title":"Neuron"},{"key":"87967_CR41","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s12035-012-8345-y","volume":"47","author":"B R\u00e1cz","year":"2013","unstructured":"R\u00e1cz, B. & Weinberg, R. J. Microdomains in forebrain spines: An ultrastructural perspective. Mol. Neurobiol. 47, 77\u201389. https:\/\/doi.org\/10.1007\/s12035-012-8345-y (2013).","journal-title":"Mol. Neurobiol."},{"key":"87967_CR42","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/978-4-431-56550-5_10","volume":"1006","author":"H Takahashi","year":"2017","unstructured":"Takahashi, H. & Naito, Y. Drebrin and spine formation. Adv. Exp. Med. Biol. 1006, 157\u2013181. https:\/\/doi.org\/10.1007\/978-4-431-56550-5_10 (2017).","journal-title":"Adv. Exp. Med. Biol."},{"key":"87967_CR43","doi-asserted-by":"publisher","first-page":"11604","DOI":"10.1523\/JNEUROSCI.0983-07.2007","volume":"27","author":"L-H Zeng","year":"2007","unstructured":"Zeng, L.-H. et al. Kainate seizures cause acute dendritic injury and actin depolymerization in vivo. J. Neurosci. 27, 11604\u201311613. https:\/\/doi.org\/10.1523\/JNEUROSCI.0983-07.2007 (2007).","journal-title":"J. Neurosci."},{"key":"87967_CR44","doi-asserted-by":"publisher","first-page":"5797","DOI":"10.1523\/JNEUROSCI.22-14-05797.2002","volume":"22","author":"CA Haas","year":"2002","unstructured":"Haas, C. A. et al. Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy. J. Neurosci. 22, 5797\u20135802. https:\/\/doi.org\/10.1523\/JNEUROSCI.22-14-05797.2002 (2002).","journal-title":"J. Neurosci."},{"key":"87967_CR45","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s00726-005-0281-y","volume":"30","author":"JW Yang","year":"2006","unstructured":"Yang, J. W., Czech, T., Felizardo, M., Baumgartner, C. & Lubec, G. Aberrant expression of cytoskeleton proteins in hippocampus from patients with mesial temporal lobe epilepsy. Amino Acids 30, 477\u2013493. https:\/\/doi.org\/10.1007\/s00726-005-0281-y (2006).","journal-title":"Amino Acids"},{"key":"87967_CR46","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/S0896-6273(03)00206-X","volume":"38","author":"Y Fukazawa","year":"2003","unstructured":"Fukazawa, Y. et al. Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo. Neuron 38, 447\u2013460. https:\/\/doi.org\/10.1016\/S0896-6273(03)00206-X (2003).","journal-title":"Neuron"},{"key":"87967_CR47","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.mcn.2005.11.003","volume":"31","author":"Y Sekino","year":"2006","unstructured":"Sekino, Y. et al. Activation of N-methyl-d-aspartate receptor induces a shift of drebrin distribution: Disappearance from dendritic spines and appearance in dendritic shafts. Mol. Cell. Neurosci. 31, 493\u2013504. https:\/\/doi.org\/10.1016\/j.mcn.2005.11.003 (2006).","journal-title":"Mol. Cell. Neurosci."},{"key":"87967_CR48","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.neuropharm.2011.09.024","volume":"62","author":"SB Schulz","year":"2012","unstructured":"Schulz, S. B., Klaft, Z. J., R\u00f6sler, A. R., Heinemann, U. & Gerevich, Z. Purinergic P2X, P2Y and adenosine receptors differentially modulate hippocampal gamma oscillations. Neuropharmacology 62, 914\u2013924. https:\/\/doi.org\/10.1016\/j.neuropharm.2011.09.024 (2012).","journal-title":"Neuropharmacology"},{"key":"87967_CR49","doi-asserted-by":"publisher","first-page":"10239","DOI":"10.1074\/jbc.M115.700138","volume":"291","author":"S Schr\u00f6tter","year":"2016","unstructured":"Schr\u00f6tter, S., Leondaritis, G. & Eickholt, B. J. Capillary isoelectric focusing of akt isoforms identifies highly dynamic phosphorylation in neuronal cells and brain tissue. J. Biol. Chem. 291, 10239\u201310251. https:\/\/doi.org\/10.1074\/jbc.M115.700138 (2016).","journal-title":"J. Biol. Chem."},{"key":"87967_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pbio.3000411","volume":"18","author":"NP du Sert","year":"2020","unstructured":"du Sert, N. P. et al. Reporting animal research: Explanation and elaboration for the arrive guidelines 2.0. PLoS Biol. 18, 1\u201365. https:\/\/doi.org\/10.1371\/journal.pbio.3000411 (2020).","journal-title":"PLoS Biol."},{"key":"87967_CR51","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.schres.2017.01.017","volume":"188","author":"CE Lemercier","year":"2017","unstructured":"Lemercier, C. E., Holman, C. & Gerevich, Z. Aberrant alpha and gamma oscillations ex vivo after single application of the NMDA receptor antagonist MK-801. Schizophr. Res. 188, 118\u2013124. https:\/\/doi.org\/10.1016\/j.schres.2017.01.017 (2017).","journal-title":"Schizophr. Res."},{"key":"87967_CR52","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1111\/bph.14923","volume":"177","author":"MA Meier","year":"2020","unstructured":"Meier, M. A. et al. The novel antipsychotic cariprazine stabilizes gamma oscillations in rat hippocampal slices. Br. J. Pharmacol. 177, 1622\u20131634. https:\/\/doi.org\/10.1111\/bph.14923 (2020).","journal-title":"Br. J. Pharmacol."},{"key":"87967_CR53","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1111\/j.1476-5381.2012.02107.x","volume":"167","author":"SB Schulz","year":"2012","unstructured":"Schulz, S. B. et al. First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br. J. Pharmacol. 167, 1480\u20131491. https:\/\/doi.org\/10.1111\/j.1476-5381.2012.02107.x (2012).","journal-title":"Br. J. Pharmacol."},{"key":"87967_CR54","first-page":"908","volume":"35","author":"TBL Kirkwood","year":"1979","unstructured":"Kirkwood, T. B. L. Geometric means and measures of dispersion. Biometrics 35, 908\u2013909 (1979).","journal-title":"Biometrics"},{"key":"87967_CR55","doi-asserted-by":"publisher","first-page":"4260","DOI":"10.1523\/JNEUROSCI.4000-04.2005","volume":"25","author":"R Kovacs","year":"2005","unstructured":"Kov\u00e1cs, R., Kardos, J., Heinemann, U.\u00a0& Kann, O. Mitochondrial calcium ion and membrane potential transients follow the pattern of epileptiform discharges in hippocampal slice cultures. J. Neurosci. 25, 4260\u20134269. https:\/\/doi.org\/10.1523\/JNEUROSCI.4000-04.2005 (2005).","journal-title":"J. Neurosci."},{"key":"87967_CR56","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1111\/j.1528-1167.2012.03724.x","volume":"53","author":"ZJ Klaft","year":"2012","unstructured":"Klaft, Z. J. et al. Extracellular ATP differentially affects epileptiform activity via purinergic P2X7 and adenosine A1 receptors in naive and chronic epileptic rats. Epilepsia 53, 1978\u20131986. https:\/\/doi.org\/10.1111\/j.1528-1167.2012.03724.x (2012).","journal-title":"Epilepsia"},{"key":"87967_CR57","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1111\/epi.13360","volume":"57","author":"ZJ Klaft","year":"2016","unstructured":"Klaft, Z. J. et al. Adenosine A1receptor-mediated suppression of carbamazepine-resistant seizure-like events in human neocortical slices. Epilepsia 57, 746\u2013756. https:\/\/doi.org\/10.1111\/epi.13360 (2016).","journal-title":"Epilepsia"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-87967-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-87967-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-87967-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T07:02:41Z","timestamp":1670050961000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-87967-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,21]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["87967"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-87967-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,21]]},"assertion":[{"value":"1 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8662"}}