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Inflammatory processes have adverse effects on vision by affecting photoreceptor-bearing cells that do not regenerate. This study aimed at characterizing inflammatory CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell subsets in the peripheral blood of active and inactive BSRCs. Furthermore, we correlated phenotypical and functional immunological analyses with clinical data. We observed a slight increase of terminally differentiated effector memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells expressing CD45RA (T\n                    <jats:sub>EMRA<\/jats:sub>\n                    ) in blood of inactive, compared to active BSRCs. Moreover, we identified a trend for a decreased population of T\n                    <jats:sub>H<\/jats:sub>\n                    2 cells and increased T\n                    <jats:sub>H<\/jats:sub>\n                    1 frequencies in active BSRCs, a typical sign of ongoing autoimmune processes. Functional assays demonstrated severe and overall impairment of effector function of both, CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    inflammatory T cells, which might reflect T cell exhaustion. Although the eye is the main site of inflammation in BSRC, we observed altered T cell subset compositions in the peripheral blood, dependent on the disease status. Our results indicate that T cells may play a major role in BSRC pathology, although our cohort size is too limited for definitve conclusions. Future studies with larger BSRCs have to be performed.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-88013-0","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T06:19:00Z","timestamp":1618985940000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Analysis of peripheral inflammatory T cell subsets and their effector function in patients with Birdshot Retinochoroiditis"],"prefix":"10.1038","volume":"11","author":[{"given":"Janine","family":"Trombke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Loyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Pleyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Thiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Pohlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"issue":"1","key":"88013_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13023-016-0429-8","volume":"11","author":"E Minos","year":"2016","unstructured":"Minos, E. et al. 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