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The evolutionarily conserved tumor-suppressor protein Scribble (Scrib) serves as a nexus to transduce signals for the establishment of apicobasal and planar cell polarity during these processes. Human\n                    <jats:italic>SCRIB<\/jats:italic>\n                    gene mutations are associated with neural tube defects and this gene is located in the minimal critical region deleted in the rare Verheij syndrome. In this study, we generated brain-specific conditional cKO mouse mutants and assessed the impact of the\n                    <jats:italic>Scrib<\/jats:italic>\n                    deletion on brain morphogenesis and behavior. We showed that embryonic deletion of\n                    <jats:italic>Scrib<\/jats:italic>\n                    in the telencephalon leads to cortical thickness reduction (microcephaly) and partial corpus callosum and hippocampal commissure agenesis. We correlated these phenotypes with a disruption in various developmental mechanisms of corticogenesis including neurogenesis, neuronal migration and axonal connectivity. Finally, we show that\n                    <jats:italic>Scrib<\/jats:italic>\n                    cKO mice have psychomotor deficits such as locomotor activity impairment and memory alterations. Altogether, our results show that\n                    <jats:italic>Scrib<\/jats:italic>\n                    is essential for early brain development due to its role in several developmental cellular mechanisms that could underlie some of the deficits observed in complex neurodevelopmental pathologies.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-88147-1","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T06:13:30Z","timestamp":1619504010000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Early loss of Scribble affects cortical development, interhemispheric connectivity and psychomotor\u00a0activity"],"prefix":"10.1038","volume":"11","author":[{"given":"Jerome","family":"Ezan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mait\u00e9 M.","family":"Moreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamrat M.","family":"Mamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Shimbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Decroo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan","family":"Peyroutou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rivka","family":"Rachel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadel","family":"Tissir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Froylan Calderon","family":"de Anda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Sans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Montcouquiol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"key":"88147_CR1","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.conb.2012.04.003","volume":"22","author":"MA Lancaster","year":"2012","unstructured":"Lancaster, M. 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