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We investigated whether prefrontal oxyhemoglobin oscillation (\u0394HbO<jats:sub>2<\/jats:sub>, 0.6\u20132\u00a0Hz) was associated with decreased vascular reserve in patients with steno-occlusion in the large anterior circulation arteries. Thirty-six patients with steno-occlusion in the anterior circulation arteries (anterior cerebral artery, middle cerebral artery, and internal carotid artery) were included and compared to thirty-six control subjects. Patients were categorized into two groups (deteriorated vascular reserve vs. preserved vascular reserve) based on the results of Diamox single- photon emission computed tomography imaging. HbO<jats:sub>2<\/jats:sub> data were collected using functional near-infrared spectroscopy. The slope of \u0394HbO<jats:sub>2<\/jats:sub> and the ipsilateral\/contralateral slope ratio of \u0394HbO<jats:sub>2<\/jats:sub> were analyzed. Among the included patients (n\u2009=\u200936), 25 (69.4%) had deteriorated vascular reserve. Patients with deteriorated vascular reserve had a significantly higher average slope of \u0394HbO<jats:sub>2<\/jats:sub> on the ipsilateral side (5.01\u2009\u00b1\u20092.14) and a higher ipsilateral\/contralateral ratio (1.44\u2009\u00b1\u20090.62) compared to those with preserved vascular reserve (3.17\u2009\u00b1\u20091.36, <jats:italic>P<\/jats:italic>\u2009=\u20090.014; 0.93\u2009\u00b1\u20090.33, <jats:italic>P<\/jats:italic>\u2009=\u20090.016, respectively) or the controls (3.82\u2009\u00b1\u20091.69, <jats:italic>P<\/jats:italic>\u2009=\u20090.019; 0.94\u2009\u00b1\u20090.29, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). The ipsilateral\/contralateral \u0394HbO<jats:sub>2<\/jats:sub> ratio could be used as a surrogate for vascular reserve in patients with severe steno-occlusion in the anterior circulation arteries.<\/jats:p>","DOI":"10.1038\/s41598-021-88198-4","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T10:19:00Z","timestamp":1619000340000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The slope of cerebral oxyhemoglobin oscillation is associated with vascular reserve capacity in large artery steno-occlusion"],"prefix":"10.1038","volume":"11","author":[{"given":"Tae Jung","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Myoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Kwan","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon-Min","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9429-9597","authenticated-orcid":false,"given":"Sang-Bae","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"88198_CR1","doi-asserted-by":"publisher","first-page":"031411","DOI":"10.1117\/1.NPh.3.3.031411","volume":"3","author":"S Fantini","year":"2016","unstructured":"Fantini, S. et al. 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