{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:41:14Z","timestamp":1792042874676,"version":"4.4.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["2016\/20-30"],"award-info":[{"award-number":["2016\/20-30"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003751","name":"Ministerio de Sanidad, Servicios Sociales e Igualdad","doi-asserted-by":"publisher","award":["PNSD-2019I006"],"award-info":[{"award-number":["PNSD-2019I006"]}],"id":[{"id":"10.13039\/501100003751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003751","name":"Ministerio de Sanidad, Servicios Sociales e Igualdad","doi-asserted-by":"publisher","award":["RD16\/0017\/0020"],"award-info":[{"award-number":["RD16\/0017\/0020"]}],"id":[{"id":"10.13039\/501100003751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003751","name":"Ministerio de Sanidad, Servicios Sociales e Igualdad","doi-asserted-by":"publisher","award":["PNSD-2017I068"],"award-info":[{"award-number":["PNSD-2017I068"]}],"id":[{"id":"10.13039\/501100003751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["#AEI-SAF2017-84060-R FEDER"],"award-info":[{"award-number":["#AEI-SAF2017-84060-R FEDER"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD16\/0017\/0020"],"award-info":[{"award-number":["RD16\/0017\/0020"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2017-SGR-669"],"award-info":[{"award-number":["2017-SGR-669"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["ICREA-Acad\u00e8mia 2015"],"award-info":[{"award-number":["ICREA-Acad\u00e8mia 2015"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008454","name":"Boehringer Ingelheim Stiftung","doi-asserted-by":"publisher","award":["BIF01"],"award-info":[{"award-number":["BIF01"]}],"id":[{"id":"10.13039\/501100008454","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008454","name":"Boehringer Ingelheim Stiftung","doi-asserted-by":"publisher","award":["BIF05"],"award-info":[{"award-number":["BIF05"]}],"id":[{"id":"10.13039\/501100008454","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008454","name":"Boehringer Ingelheim Stiftung","doi-asserted-by":"publisher","award":["BIF09"],"award-info":[{"award-number":["BIF09"]}],"id":[{"id":"10.13039\/501100008454","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007569","name":"Carl-Zeiss-Stiftung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007569","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Mainz Institute of Multiscale Modeling- M3odel"},{"name":"Leibniz-Institut f\u00fcr Resilienzforschung (LIR)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Addiction is a chronic relapsing brain disease characterized by compulsive reward-seeking despite harmful consequences. The mechanisms underlying addiction are orchestrated by transcriptional reprogramming in the reward system of vulnerable subjects. This study aims at revealing gene expression alterations across different types of addiction. We analyzed publicly available transcriptome datasets of the prefrontal cortex (PFC) from a palatable food and a cocaine addiction study. We found 56 common genes upregulated in the PFC of addicted mice in these two studies, whereas most of the differentially expressed genes were exclusively linked to either palatable food or cocaine addiction. Gene ontology analysis of shared genes revealed that these genes contribute to learning and memory, dopaminergic synaptic transmission, and histone phosphorylation. Network analysis of shared genes revealed a protein\u2013protein interaction node among the G protein-coupled receptors (Drd2, Drd1, Adora2a, Gpr6, Gpr88) and downstream targets of the cAMP signaling pathway (Ppp1rb1, Rgs9, Pde10a) as a core network in addiction. Upon extending the analysis to a cell-type specific level, some of these common molecular players were selectively expressed in excitatory neurons, oligodendrocytes, and endothelial cells. Overall, computational analysis of publicly available whole transcriptome datasets provides new insights into the molecular basis of addiction-like behaviors in PFC.<\/jats:p>","DOI":"10.1038\/s41598-021-88363-9","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T10:13:30Z","timestamp":1619518410000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Transcriptional signatures in prefrontal cortex confer vulnerability versus resilience to food and cocaine addiction-like behavior"],"prefix":"10.1038","volume":"11","author":[{"given":"Mohit","family":"Navandar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Mart\u00edn-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Maldonado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Lutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Gerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inigo","family":"Ruiz de Azua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"key":"88363_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(00)00195-0","author":"GF Koob","year":"2001","unstructured":"Koob, G. F. & Le Moal, M. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology https:\/\/doi.org\/10.1016\/S0893-133X(00)00195-0 (2001).","journal-title":"Neuropsychopharmacology"},{"key":"88363_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2009.10.003","author":"S Fulton","year":"2010","unstructured":"Fulton, S. Appetite and reward. Front. Neuroendocrinol. https:\/\/doi.org\/10.1016\/j.yfrne.2009.10.003 (2010).","journal-title":"Front. Neuroendocrinol."},{"key":"88363_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.12.024","author":"DE Moorman","year":"2015","unstructured":"Moorman, D. E., James, M. H., McGlinchey, E. M. & Aston-Jones, G. Differential roles of medial prefrontal subregions in the regulation of drug seeking. Brain Res. https:\/\/doi.org\/10.1016\/j.brainres.2014.12.024 (2015).","journal-title":"Brain Res."},{"key":"88363_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2014.00230","author":"D Riga","year":"2014","unstructured":"Riga, D. et al. Optogenetic dissection of medial prefrontal cortex circuitry. Front. Syst. Neurosci. https:\/\/doi.org\/10.3389\/fnsys.2014.00230 (2014).","journal-title":"Front. Syst. Neurosci."},{"key":"88363_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14458-y","author":"L Domingo-Rodriguez","year":"2020","unstructured":"Domingo-Rodriguez, L. et al. A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction. Nat. Commun. https:\/\/doi.org\/10.1038\/s41467-020-14458-y (2020).","journal-title":"Nat. Commun."},{"key":"88363_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2015.06.007","author":"YY Tang","year":"2015","unstructured":"Tang, Y. Y., Posner, M. I., Rothbart, M. K. & Volkow, N. D. Circuitry of self-control and its role in reducing addiction. Trends Cogn. Sci. https:\/\/doi.org\/10.1016\/j.tics.2015.06.007 (2015).","journal-title":"Trends Cogn. Sci."},{"key":"88363_CR7","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099020","author":"V Deroche-Gamonet","year":"2004","unstructured":"Deroche-Gamonet, V., Belin, D. & Piazza, P. V. Evidence for addiction-like behavior in the rat. Science. https:\/\/doi.org\/10.1126\/science.1099020 (2004).","journal-title":"Science"},{"key":"88363_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.129","author":"S Mancino","year":"2015","unstructured":"Mancino, S. et al. Epigenetic and proteomic expression changes promoted by eating addictive-like behavior. Neuropsychopharmacology https:\/\/doi.org\/10.1038\/npp.2015.129 (2015).","journal-title":"Neuropsychopharmacology"},{"key":"88363_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.04.009","author":"DM Walker","year":"2018","unstructured":"Walker, D. M. et al. Cocaine self-administration alters transcriptome-wide responses in the brain\u2019s reward circuitry. Biol. Psychiatry https:\/\/doi.org\/10.1016\/j.biopsych.2018.04.009 (2018).","journal-title":"Biol. Psychiatry"},{"key":"88363_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/nn1929","author":"DL Graham","year":"2007","unstructured":"Graham, D. L. et al. Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nat. Neurosci. https:\/\/doi.org\/10.1038\/nn1929 (2007).","journal-title":"Nat. Neurosci."},{"key":"88363_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301577","author":"WM Freeman","year":"2008","unstructured":"Freeman, W. M. et al. Persistent alterations in mesolimbic gene expression with abstinence from cocaine self-administration. Neuropsychopharmacology https:\/\/doi.org\/10.1038\/sj.npp.1301577 (2008).","journal-title":"Neuropsychopharmacology"},{"key":"88363_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-11-29","author":"WM Freeman","year":"2010","unstructured":"Freeman, W. M. et al. Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration. BMC Neurosci. https:\/\/doi.org\/10.1186\/1471-2202-11-29 (2010).","journal-title":"BMC Neurosci."},{"key":"88363_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.130","author":"ND Volkow","year":"2017","unstructured":"Volkow, N. D., Wise, R. A. & Baler, R. The dopamine motive system: Implications for drug and food addiction. Nat. Rev. Neurosci. https:\/\/doi.org\/10.1038\/nrn.2017.130 (2017).","journal-title":"Nat. Rev. Neurosci."},{"key":"88363_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12054-3","author":"A Bhattacherjee","year":"2019","unstructured":"Bhattacherjee, A. et al. Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction. Nat. Commun. https:\/\/doi.org\/10.1038\/s41467-019-12054-3 (2019).","journal-title":"Nat. Commun."},{"key":"88363_CR15","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1131","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk, D. et al. STRING v11: Protein\u2013protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. https:\/\/doi.org\/10.1093\/nar\/gky1131 (2019).","journal-title":"Nucleic Acids Res."},{"key":"88363_CR16","doi-asserted-by":"publisher","DOI":"10.1134\/S199075081702010X","author":"NL Vekshina","year":"2017","unstructured":"Vekshina, N. L., Anokhin, P. K., Veretinskaya, A. G. & Shamakina, I. Y. Dopamine D1\u2013D2 receptor heterodimers: A literature review. Biochem. (Moscow) Suppl. Series B Biomed. Chem. https:\/\/doi.org\/10.1134\/S199075081702010X (2017).","journal-title":"Biochem. (Moscow) Suppl. Series B Biomed. Chem."},{"key":"88363_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03522-3","author":"G Navarro","year":"2018","unstructured":"Navarro, G. et al. Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase. Nat. Commun. https:\/\/doi.org\/10.1038\/s41467-018-03522-3 (2018).","journal-title":"Nat. Commun."},{"key":"88363_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2019.03.021","author":"TT Fraporti","year":"2019","unstructured":"Fraporti, T. T. et al. Synergistic effects between ADORA2A and DRD2 genes on anxiety disorders in children with ADHD. Prog. Neuro-Psychopharmacol. Biol. Psychiatry https:\/\/doi.org\/10.1016\/j.pnpbp.2019.03.021 (2019).","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"88363_CR19","unstructured":"Smith,, J. P. & Book, S. W. Anxiety and substance use disorders: A review. Psychiatr. Times 25(10) 19\u201323 (2008)."},{"key":"88363_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3119","author":"RZ Goldstein","year":"2011","unstructured":"Goldstein, R. Z. & Volkow, N. D. Dysfunction of the prefrontal cortex in addiction: Neuroimaging findings and clinical implications. Nat. Rev. Neurosci. https:\/\/doi.org\/10.1038\/nrn3119 (2011).","journal-title":"Nat. Rev. Neurosci."},{"key":"88363_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/nature12024","author":"BT Chen","year":"2013","unstructured":"Chen, B. T. et al. Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking. Nature https:\/\/doi.org\/10.1038\/nature12024 (2013).","journal-title":"Nature"},{"key":"88363_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.178","author":"AS Hauser","year":"2017","unstructured":"Hauser, A. S., Attwood, M. M., Rask-Andersen, M., Schi\u00f6th, H. B. & Gloriam, D. E. Trends in GPCR drug discovery: New agents, targets and indications. Nat. Rev. Drug Discov. https:\/\/doi.org\/10.1038\/nrd.2017.178 (2017).","journal-title":"Nat. Rev. Drug Discov."},{"key":"88363_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3625","author":"BB Land","year":"2014","unstructured":"Land, B. B. et al. Medial prefrontal D1 dopamine neurons control food intake. Nat. Neurosci. https:\/\/doi.org\/10.1038\/nn.3625 (2014).","journal-title":"Nat. Neurosci."},{"key":"88363_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3239","author":"A Quintana","year":"2012","unstructured":"Quintana, A. et al. Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors. Nat. Neurosci. https:\/\/doi.org\/10.1038\/nn.3239 (2012).","journal-title":"Nat. Neurosci."},{"key":"88363_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.01.026","author":"S Ben Hamida","year":"2018","unstructured":"Ben Hamida, S. et al. Increased alcohol seeking in mice lacking Gpr88 involves dysfunctional mesocorticolimbic networks. Biol. Psychiatry https:\/\/doi.org\/10.1016\/j.biopsych.2018.01.026 (2018).","journal-title":"Biol. Psychiatry"},{"key":"88363_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.68","author":"P Suchankova","year":"2015","unstructured":"Suchankova, P. et al. The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: Evidence from human genetic association studies and a mouse model of alcohol dependence. Transl. Psychiatry https:\/\/doi.org\/10.1038\/tp.2015.68 (2015).","journal-title":"Transl. Psychiatry"},{"key":"88363_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09480-8","author":"HR Kranzler","year":"2019","unstructured":"Kranzler, H. R. et al. Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. Nat. Commun. https:\/\/doi.org\/10.1038\/s41467-019-09480-8 (2019).","journal-title":"Nat. Commun."},{"key":"88363_CR28","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5306.1593","author":"W Schultz","year":"1997","unstructured":"Schultz, W., Dayan, P. & Montague, P. R. A neural substrate of prediction and reward. Science (80-). https:\/\/doi.org\/10.1126\/science.275.5306.1593 (1997).","journal-title":"Science (80-)."},{"key":"88363_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(93)90013-P","author":"TE Robinson","year":"1993","unstructured":"Robinson, T. E. & Berridge, K. C. The neural basis of drug craving: An incentive-sensitization theory of addiction. Brain Res. Rev. https:\/\/doi.org\/10.1016\/0165-0173(93)90013-P (1993).","journal-title":"Brain Res. Rev."},{"key":"88363_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0682-1","author":"CM Vander Weele","year":"2018","unstructured":"Vander Weele, C. M. et al. Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli. Nature https:\/\/doi.org\/10.1038\/s41586-018-0682-1 (2018).","journal-title":"Nature"},{"key":"88363_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.01.017","author":"C L\u00fcscher","year":"2011","unstructured":"L\u00fcscher, C. & Malenka, R. C. Drug-evoked synaptic plasticity in addiction: From molecular changes to circuit remodeling. Neuron https:\/\/doi.org\/10.1016\/j.neuron.2011.01.017 (2011).","journal-title":"Neuron"},{"key":"88363_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.04.004","author":"EJ Nestler","year":"2014","unstructured":"Nestler, E. J. Epigenetic mechanisms of drug addiction. Neuropharmacology https:\/\/doi.org\/10.1016\/j.neuropharm.2013.04.004 (2014).","journal-title":"Neuropharmacology"},{"key":"88363_CR33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04352.x","author":"K Brami-Cherrier","year":"2007","unstructured":"Brami-Cherrier, K., Lavaur, J., Pag\u00e8s, C., Arthur, J. S. C. & Caboche, J. Glutamate induces histone H3 phosphorylation but not acetylation in striatal neurons: Role of mitogen- and stress-activated kinase-1. J. Neurochem. https:\/\/doi.org\/10.1111\/j.1471-4159.2006.04352.x (2007).","journal-title":"J. Neurochem."},{"key":"88363_CR34","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1711-05.2005","author":"K Brami-Cherrier","year":"2005","unstructured":"Brami-Cherrier, K. et al. Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice. J. Neurosci. https:\/\/doi.org\/10.1523\/JNEUROSCI.1711-05.2005 (2005).","journal-title":"J. Neurosci."},{"key":"88363_CR35","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1039-08.2008","author":"J Bertran-Gonzalez","year":"2008","unstructured":"Bertran-Gonzalez, J. et al. Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol. J. Neurosci. https:\/\/doi.org\/10.1523\/JNEUROSCI.1039-08.2008 (2008).","journal-title":"J. Neurosci."},{"key":"88363_CR36","doi-asserted-by":"publisher","unstructured":"Stipanovich, A. et al. A phosphatase cascade by which natural rewards and drugs of abuse regulate nucleosomal response in the mouse. Nature. https:\/\/doi.org\/10.1038\/nature06994 (2008). \u00a0","DOI":"10.1038\/nature06994"},{"key":"88363_CR37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034973","author":"J K\u00f6hler","year":"2012","unstructured":"K\u00f6hler, J. et al. Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells. PLoS ONE https:\/\/doi.org\/10.1371\/journal.pone.0034973 (2012).","journal-title":"PLoS ONE"},{"key":"88363_CR38","doi-asserted-by":"publisher","DOI":"10.7150\/thno.8799","author":"R Pacaud","year":"2015","unstructured":"Pacaud, R., Cheray, M., Nadaradjane, A., Vallette, F. M. & Cartron, P. F. Histone H3 phosphorylation in GBM: A new rational to guide the use of kinase inhibitors in anti-GBM therapy. Theranostics https:\/\/doi.org\/10.7150\/thno.8799 (2015).","journal-title":"Theranostics"},{"key":"88363_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2009.11.008","author":"R Rozenfeld","year":"2010","unstructured":"Rozenfeld, R. & Devi, L. A. Receptor heteromerization and drug discovery. Trends Pharmacol. Sci. https:\/\/doi.org\/10.1016\/j.tips.2009.11.008 (2010).","journal-title":"Trends Pharmacol. Sci."},{"key":"88363_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.12.139","author":"BF O\u2019Dowd","year":"2013","unstructured":"O\u2019Dowd, B. F., Nguyen, T., Ji, X. & George, S. R. D5 dopamine receptor carboxyl tail involved in D5\u2013D2 heteromer formation. Biochem. Biophys. Res. Commun. https:\/\/doi.org\/10.1016\/j.bbrc.2012.12.139 (2013).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"88363_CR41","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.50519","author":"T Laboute","year":"2020","unstructured":"Laboute, T. et al. The orphan receptor gpr88 blunts the signaling of opioid receptors and multiple striatal gpcrs. Elife https:\/\/doi.org\/10.7554\/eLife.50519 (2020).","journal-title":"Elife"},{"key":"88363_CR42","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002922","author":"K Xie","year":"2012","unstructured":"Xie, K., Masuho, I., Brand, C., Dessauer, C. W. & Martemyanov, K. A. The complex of G protein regulator RGS9-2 and G\u03b25 controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum. Sci. Signal. https:\/\/doi.org\/10.1126\/scisignal.2002922 (2012).","journal-title":"Sci. Signal."},{"key":"88363_CR43","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20303","author":"P Seeman","year":"2006","unstructured":"Seeman, P. et al. Psychosis pathways converge via D2High dopamine receptors. Synapse https:\/\/doi.org\/10.1002\/syn.20303 (2006).","journal-title":"Synapse"},{"key":"88363_CR44","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.44.101802.121415","author":"P Svenningsson","year":"2004","unstructured":"Svenningsson, P. et al. DARPP-32: An integrator of neurotransmission. Annu. Rev. Pharmacol. Toxicol. https:\/\/doi.org\/10.1146\/annurev.pharmtox.44.101802.121415 (2004).","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"88363_CR45","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2518-08.2008","author":"A Nishi","year":"2008","unstructured":"Nishi, A. et al. Distinct roles of PDE4 and PDE10A in the regulation of cAMP\/PKA signaling in the striatum. J. Neurosci. https:\/\/doi.org\/10.1523\/JNEUROSCI.2518-08.2008 (2008).","journal-title":"J. Neurosci."},{"key":"88363_CR46","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-014-3818-5","author":"K Wydra","year":"2015","unstructured":"Wydra, K., Suder, A., Borroto-Escuela, D. O., Filip, M. & Fuxe, K. On the role of A2A and D2 receptors in control of cocaine and food-seeking behaviors in rats. Psychopharmacology https:\/\/doi.org\/10.1007\/s00213-014-3818-5 (2015).","journal-title":"Psychopharmacology"},{"key":"88363_CR47","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00985","author":"I Ballesteros-Y\u00e1\u00f1ez","year":"2018","unstructured":"Ballesteros-Y\u00e1\u00f1ez, I., Castillo, C. A., Merighi, S. & Gessi, S. The role of adenosine receptors in psychostimulant addiction. Front. Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2017.00985 (2018).","journal-title":"Front. Pharmacol."},{"key":"88363_CR48","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1621","author":"C Trapnell","year":"2010","unstructured":"Trapnell, C. et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat. Biotechnol. https:\/\/doi.org\/10.1038\/nbt.1621 (2010).","journal-title":"Nat. Biotechnol."},{"key":"88363_CR49","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638","author":"S Anders","year":"2015","unstructured":"Anders, S., Pyl, P. T. & Huber, W. HTSeq\u2014A Python framework to work with high-throughput sequencing data. Bioinformatics https:\/\/doi.org\/10.1093\/bioinformatics\/btu638 (2015).","journal-title":"Bioinformatics"},{"key":"88363_CR50","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-10-r106","author":"S Anders","year":"2010","unstructured":"Anders, S. & Huber, W. Differential expression analysis for sequence count data. Genome Biol. https:\/\/doi.org\/10.1186\/gb-2010-11-10-r106 (2010).","journal-title":"Genome Biol."},{"key":"88363_CR51","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp427","author":"J Chen","year":"2009","unstructured":"Chen, J., Bardes, E. E., Aronow, B. J. & Jegga, A. G. ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res. https:\/\/doi.org\/10.1093\/nar\/gkp427 (2009).","journal-title":"Nucleic Acids Res."},{"key":"88363_CR52","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303","author":"P Shannon","year":"2003","unstructured":"Shannon, P. et al. Cytoscape: A software Environment for integrated models of biomolecular interaction networks. Genome Res. https:\/\/doi.org\/10.1101\/gr.1239303 (2003).","journal-title":"Genome Res."},{"key":"88363_CR53","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4096","author":"A Butler","year":"2018","unstructured":"Butler, A., Hoffman, P., Smibert, P., Papalexi, E. & Satija, R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat. Biotechnol. https:\/\/doi.org\/10.1038\/nbt.4096 (2018).","journal-title":"Nat. Biotechnol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-88363-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-88363-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-88363-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T07:12:46Z","timestamp":1670051566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-88363-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,27]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["88363"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-88363-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,27]]},"assertion":[{"value":"4 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"9076"}}