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We propose a new integrative model by combining two sub-models. The first one for the dynamics of a livestock epidemic on a metapopulation network, grounded on demographic and animal trade data. The second one for farmers\u2019 behavior regarding the adoption of a control measure against the disease spread in their herd. The measure is specified as a protective vaccine with given economic implications, and the model is numerically studied through intensive simulations and sensitivity analyses. While each tested parameter of the model has an impact on the overall model behavior, the most important factor in farmers\u2019 decisions is their frequency, as this factor explained almost 30% of the variation in decision-related outputs of the model. Indeed, updating frequently local health information impacts positively vaccination, and limits strongly the propagation of the pathogen. Our study is relevant for the understanding of the interplay between decision-related human behavior and livestock epidemic dynamics. 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