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TGF\u03b2 ligands signal through the TGF\u03b2 receptor type 2 (TGFBR2)\/TGFBR1 complex. As TGFBR2 and TGFBR1 form a signaling complex upon ligand stimulation, they are expected to be equally important for propagating TGF\u03b2 signaling that elicits cellular responses. However, several genetic studies challenge this concept and indicate that disruption of TGFBR2 or TGFBR1 may lead to contrasting phenotypic outcomes. We have shown that conditional deletion of <jats:italic>Tgfbr1<\/jats:italic> using anti-Mullerian hormone receptor\u00a0type 2 (<jats:italic>Amhr2<\/jats:italic>)-Cre causes oviductal and myometrial defects. To determine the functional requirement of TGFBR2 in the female reproductive tract and the potential phenotypic divergence\/similarity resulting from conditional ablation of either receptor, we generated mice harboring <jats:italic>Tgfbr2<\/jats:italic> deletion using the same Cre driver that was previously employed to target <jats:italic>Tgfbr1<\/jats:italic>. Herein, we found that conditional deletion of <jats:italic>Tgfbr2<\/jats:italic> led to a similar phenotype to that of <jats:italic>Tgfbr1<\/jats:italic> deletion in the female reproductive tract. Furthermore, genetic removal of <jats:italic>Tgfbr1<\/jats:italic> in the <jats:italic>Tgfbr2<\/jats:italic>-deleted uterus had minimal impact on the phenotype of <jats:italic>Tgfbr2<\/jats:italic> conditional knockout mice. In summary, our results reveal the functional similarity between TGFBR2 and TGFBR1 in maintaining the structural integrity of the female reproductive tract.<\/jats:p>","DOI":"10.1038\/s41598-021-88673-y","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T10:05:37Z","timestamp":1619690737000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Functional similarity between TGF-beta type 2 and type 1 receptors in the female reproductive tract"],"prefix":"10.1038","volume":"11","author":[{"given":"Nan","family":"Ni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinglei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"88673_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/wdev.86","volume":"2","author":"A Weiss","year":"2013","unstructured":"Weiss, A. & Attisano, L. 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