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A multicenter, observational, descriptive and cross-sectional study of consecutive patients diagnosed with RA-ILD. Demographic, analytical, respiratory functional and evolution characteristics were analyzed to evaluate the predictors of progression and mortality. 106 patients were included. The multivariate analysis showed that the diagnostic delay was an independent predictor of mortality (HR 1.11, CI 1.01\u20131.23,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.035). Also, age (HR 1.33, 95% CI 1.09\u20131.62,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0045), DLCO (%) (HR 0.85, 95% CI 0.73\u20130.98,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0246), and final SatO2 (%) in the 6MWT (HR 0.62, 95% CI 0.39\u20130.99,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0465) were independent predictor variables of mortality, as well as GAP index (HR 4.65, 95% CI 1.59\u201313.54,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0051) and CPI index (HR 1.12, 95% CI 1.03\u20131.22,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0092). The withdrawal of MTX or LFN after ILD diagnosis was associated with disease progression in the COX analysis (HR 2.18, 95% CI 1.14\u20134.18,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.019). This is the first study that highlights the diagnostic delay in RA-ILD is associated with an increased mortality just like happens in IPF.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-88734-2","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T06:04:55Z","timestamp":1619589895000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis"],"prefix":"10.1038","volume":"11","author":[{"given":"Esteban","family":"Cano-Jim\u00e9nez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1s","family":"V\u00e1zquez Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Mart\u00edn-Robles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Castillo Villegas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Juan Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bollo de Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Robles-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ferrer Galv\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Mouronte Roibas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Herrera Lara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Bermudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Garc\u00eda Moyano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Rodr\u00edguez Portal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobo","family":"Sellar\u00e9s Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Narv\u00e1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Molina-Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"key":"88734_CR1","first-page":"21","volume":"4","author":"JJ Solomon","year":"2012","unstructured":"Solomon, J. 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