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Therefore the current comprehensive study was performed to determine the global status of <jats:italic>T. gondii<\/jats:italic> infection in domestic and wild felids aiming to provide comprehensive data of interest for further intervention approaching the One Health perspective. Different databases were searched by utilizing particular key words for publications related to <jats:italic>T. gondii<\/jats:italic> infecting domestic and wild feline host species, worldwide, from 1970 to 2020. The review of 337 reports showed that the seroprevalence of <jats:italic>T. gondii<\/jats:italic> in domestic cats and wild felids was estimated in 37.5% (95% CI 34.7\u201340.3) (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200998.3%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and 64% (95% CI 60\u201367.9) (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200988%, P\u2009&lt;\u20090.0001), respectively. The global pooled prevalence of oocysts in the fecal examined specimens from domestic cats was estimated in 2.6% (95% CI 1.9\u20133.3) (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200996.1%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), and that in fecal samples from wild felids was estimated in 2.4% (95% CI 1.1\u20134.2) (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200986.4%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). In addition, from 13,252 examined soil samples in 14 reviewed studies, the pooled occurrence of <jats:italic>T. gondii<\/jats:italic> oocysts was determined in 16.2% (95% CI 7.66\u201327.03%). The observed high rates of anti-<jats:italic>T. gondii<\/jats:italic> antibodies seroprevalence levels and oocyst excretion frequency in the felids, along with soil (environmental) contamination with oocysts may constitute a potential threat to animal and public health, and data will result of interest in further prophylaxis programs.<\/jats:p>","DOI":"10.1038\/s41598-021-89031-8","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T10:03:29Z","timestamp":1620122609000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Toxoplasma gondii infection in domestic and wild felids as public health concerns: a systematic review and meta-analysis"],"prefix":"10.1038","volume":"11","author":[{"given":"Kareem","family":"Hatam-Nahavandi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Calero-Bernal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Taghi","family":"Rahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdol Sattar","family":"Pagheh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Zarean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asiyeh","family":"Dezhkam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Ahmadpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,4]]},"reference":[{"key":"89031_CR1","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/1756-3305-3-112","volume":"3","author":"JP Webster","year":"2010","unstructured":"Webster, J. 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