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Analysis of covariance models were used to assess HRQoL scores in relation to presence of lymphedema and lymphedema-related symptoms. Lymphedema was self-reported by 137 women, of whom 98 were experiencing lymphedema at the time of the assessment. The most common symptoms were heaviness (52%), numbness (47%), and tightness (45%). Perceived physical health was worse for women reporting past or current lymphedema than those reporting no lymphedema (<jats:italic>P<\/jats:italic>-value\u2009&lt;\u20090.0001). No difference was observed for perceived mental health (<jats:italic>P<\/jats:italic>-value\u2009=\u20090.31). Perceived physical health, stress, and lymphedema-specific HRQoL scores worsened as number of symptoms increased (<jats:italic>P<\/jats:italic>-values\u2009\u2264\u20090.01). Women reporting tension in the arm had lower physical health (<jats:italic>P<\/jats:italic>-value\u2009=\u20090.01), and those experiencing burning pain, tension, heaviness, or warmth\/redness in the arm had lower lymphedema-specific HRQoL (<jats:italic>P<\/jats:italic>-values\u2009&lt;\u20090.05). Treatment targeting specific lymphedema-related symptoms in addition to size\/volume reduction may improve some aspects of HRQoL among affected women.<\/jats:p>","DOI":"10.1038\/s41598-021-89055-0","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T10:02:50Z","timestamp":1621591370000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Self-reported symptoms of arm lymphedema and health-related quality of life among female breast cancer survivors"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6470-7775","authenticated-orcid":false,"given":"Kayo","family":"Togawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley Wilder","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian L.","family":"Neuhouser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy B.","family":"Baumgartner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"McTiernan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Baumgartner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M.","family":"Ballard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,21]]},"reference":[{"issue":"5","key":"89055_CR1","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3322\/caac.21565","volume":"69","author":"KD Miller","year":"2019","unstructured":"Miller, K. 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