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One potential treatment is vagus nerve stimulation (VNS), which activates\u00a0the sensory afferents innervating the stomach that convey stomach volume and\u00a0establish\u00a0satiety. However, current VNS approaches and stimulus optimization could benefit from additional understanding of the underlying neural response to stomach distension. In this study,\u00a0obesity-prone Sprague Dawley\u00a0rats\u00a0consumed\u00a0a standard, high-carbohydrate, or high-fat diet for several months, leading to diet-induced obesity in the latter two groups.\u00a0Under anesthesia, the neural\u00a0activity\u00a0in the\u00a0vagus\u00a0nerve was recorded with a penetrating microelectrode array\u00a0while the stomach was distended with an implanted balloon. Vagal tone during distension was compared to baseline tone prior to distension.\u00a0Responses were\u00a0strongly correlated with stomach\u00a0distension,\u00a0but the sensitivity to distension was significantly\u00a0lower\u00a0in animals that had been fed the nonstandard diets. The results indicate that both high fat and high carbohydrate diets impair\u00a0vagus\u00a0activity.<\/jats:p>","DOI":"10.1038\/s41598-021-89465-0","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T10:04:53Z","timestamp":1621245893000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Both high fat and high carbohydrate diets impair vagus nerve signaling of satiety"],"prefix":"10.1038","volume":"11","author":[{"given":"Hailley","family":"Loper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Leinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan","family":"Bassoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Sample","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Romero-Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Gustafson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn M.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Schiefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"89465_CR1","first-page":"1","volume":"82","author":"CL Ogden","year":"2012","unstructured":"Ogden, C. 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