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Interacting with virtual objects via embodied avatar hands increased the illusion of \u201cbeing there\u201d in the virtual world, increased VR analgesia for acute pain, and reduced accuracy on an attention demanding task. Twenty-four healthy volunteer college students participated in this within-subject randomized crossover design study. During Phase 1, each participant received brief thermal pain stimuli during interactive embodied avatar VR vs. passive VR (no avatar and no interactivity), VR treatment order randomized. After each pain stimulus, participants provided subjective 0\u201310 ratings of pain. Compared to the passive VR condition, during the interactive avatar VR, participants reported significant reductions in (1) worst pain, (2) pain unpleasantness, (3) time thinking about pain and (4). they had significantly more fun during the pain stimulus (<jats:italic>p<\/jats:italic>\u2009=\u2009.000 for each). During Phase 2, participants performed a divided attention task in each of the two VR conditions. Participants made significantly more errors on the divided attention task during the interactive avatar VR condition, compared to passive VR, implicating an attention mechanism for how virtual reality reduces pain and helping understand how VR influences pain perception.<\/jats:p><jats:p>Trial registration: NCT04245475. Date of registration: 29\/01\/2020.<\/jats:p>","DOI":"10.1038\/s41598-021-89526-4","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T10:02:50Z","timestamp":1621591370000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Interacting with virtual objects via embodied avatar hands reduces pain intensity and diverts attention"],"prefix":"10.1038","volume":"11","author":[{"given":"Hunter G.","family":"Hoffman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,21]]},"reference":[{"key":"89526_CR1","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1016\/j.pain.2012.05.030","volume":"153","author":"FJ Keefe","year":"2012","unstructured":"Keefe, F. J. et al. Virtual reality for persistent pain: a new direction for behavioral pain management. 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