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This nationwide retrospective cohort study included 5621 discharged patients with COVID-19, extracted from the Korea Disease Control and Prevention Agency (KDCA) database. We compared clinical data between survivors (n\u2009=\u20095387) and non-survivors (n\u2009=\u2009234). We used logistic regression analysis and Cox proportional hazards model to explore risk factors of death and fatal adverse outcomes. Increased odds ratio (OR) of mortality occurred with age (\u2265\u200960\u00a0years) [OR 11.685, 95% confidence interval (CI) 4.655\u201334.150,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001], isolation period, dyspnoea, altered mentality, diabetes, malignancy, dementia, and intensive care unit (ICU) admission. The multivariable regression equation including all potential variables predicted mortality (AUC\u2009=\u20090.979, 95% CI 0.964\u20130.993). Cox proportional hazards model showed increasing hazard ratio (HR) of mortality with dementia (HR 6.376, 95% CI 3.736\u201310.802,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), ICU admission (HR 4.233, 95% CI 2.661\u20136.734,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), age\u2009\u2265\u200960\u00a0years (HR 3.530, 95% CI 1.664\u20137.485,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001), malignancy (HR 3.054, 95% CI 1.494\u20136.245,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002), and dyspnoea (HR 1.823, 95% CI 1.125\u20132.954,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.015). Presence of dementia, ICU admission, age\u2009\u2265\u200960\u00a0years, malignancy, and dyspnoea could help clinicians identify COVID-19 patients with poor prognosis.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-89548-y","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T06:03:45Z","timestamp":1620799425000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Clinical course and risk factors of fatal adverse outcomes in COVID-19 patients in Korea: a nationwide retrospective cohort study"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6217-7360","authenticated-orcid":false,"given":"Juhyun","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Won","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-hyung","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeri","family":"Seok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Yeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9481-6358","authenticated-orcid":false,"given":"Jonghak","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanjin","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"89548_CR1","unstructured":"Coronavirus Resource Center. 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