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We aimed to investigate the independent impact of COVID-19 infection on the mortality of these patients. Healthcare databases were systematically searched over 2-weeks from 1st\u201314th November 2020 to identify eligible studies assessing the impact of COVID-19 on hip fracture patients. Meta-analysis of proportion was performed to obtain pooled values of prevalence, incidence and case fatality rate of hip fracture patients with COVID-19 infection. 30-day mortality, excess mortality and all-cause mortality were analysed using a mixed-effects model. 22 studies reporting 4015 patients were identified out of which 2651 (66%) were assessed during the pandemic. An excess mortality of 10% was seen for hip fractures treated during the pandemic (OR 2.00, p\u2009=\u20090.007), in comparison to the pre-pandemic controls (5%). Estimated mortality of COVID-19 positive hip fracture patients was four-fold (RR 4.59, p\u2009&lt;\u20090.0001) and 30-day mortality was 38.0% (HR 4.73, p\u2009&lt;\u20090.0001). The case fatality rate for COVID-19 positive patients was 34.74%. Between-study heterogeneity for the pooled analysis was minimal (I<jats:sup>2<\/jats:sup>\u2009=\u20090.00) whereas, random effects metaregression identified subgroup heterogeneity for male gender (p\u2009&lt;\u20090.001), diabetes (p\u2009=\u20090.002), dementia (p\u2009=\u20090.001) and extracapsular fractures (p\u2009=\u20090.01) increased risk of mortality in COVID-19 positive patients.<\/jats:p>","DOI":"10.1038\/s41598-021-89617-2","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T10:03:45Z","timestamp":1620813825000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Meta-analysis and metaregression of risk factors associated with mortality in hip fracture patients during the COVID-19 pandemic"],"prefix":"10.1038","volume":"11","author":[{"given":"Firas J.","family":"Raheman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djamila M.","family":"Rojoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jvalant","family":"Nayan Parekh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reshid","family":"Berber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Ashford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"89617_CR1","unstructured":"Coronavirus Disease (COVID-19)\u2014events as they happen. https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/events-as-they-happen. 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