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Without surgical intervention the usual mortality rate averages between 1 and 2% per hour. Thus, an early diagnosis of ATAAD is of pivotal importance to direct the affected patients to the appropriate treatment. Preceding tests to find an appropriate biomarker showed among others an increased aggrecan (ACAN) mRNA expression in aortic tissue of ATAAD patients. As a consequence, we investigated whether ACAN is a potential biomarker for diagnosing ATAAD. Mean ACAN protein concentration showed a significantly higher plasma concentration in ATAAD patients (38.59\u00a0ng\/mL, n\u2009=\u200933) compared to plasma of patients with thoracic aortic aneurysms (4.45\u00a0ng\/mL, n\u2009=\u200913), patients with myocardial infarction (11.77\u00a0ng\/mL, n\u2009=\u200918) and healthy volunteers (8.05\u00a0ng\/mL, n\u2009=\u200912). Cardiac enzymes like creatine kinase MB and cardiac troponin T showed no correlation with ACAN levels in ATAAD patients. Receiver-operator characteristics (ROC) curve analysis for ATAAD patients versus control subjects an optimum discrimination limit of ACAN plasma levels at 14.3\u00a0ng\/mL with a corresponding sensitivity of 97% and specificity of 81%. According to our findings ACAN is a reliable potential biomarker in plasma samples to detect ATAAD with high sensitivity and specificity.<\/jats:p>","DOI":"10.1038\/s41598-021-89653-y","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T10:03:17Z","timestamp":1620986597000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Aggrecan: a new biomarker for acute type A aortic dissection"],"prefix":"10.1038","volume":"11","author":[{"given":"Karl C.","family":"K\u00f6nig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Lahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Dre\u00dfen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie A.","family":"Doppler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Eichhorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Kraehschuetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Doll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Holdenrieder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Kastrati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Krane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,14]]},"reference":[{"key":"89653_CR1","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s11748-018-0957-3","volume":"67","author":"AS Jassar","year":"2019","unstructured":"Jassar, A. 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K.C.K., H. L., M.D., R.L. and M.K. are joint partners of the patent. The other authors aren\u00b4t joint partners of the above mentioned patent. The authors without competing interests are in particular Nicole Beck, Stefanie Doppler, Sophia Doll, Kathrin Kr\u00e4hsch\u00fctz, Stefan Eichhorn, Stefan Holdenrieder and Adnan Kastrati.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10371"}}