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Adult patients experiencing in-hospital cardiac arrest (IHCA) from 2006 to 2015 were retrospectively screened. Early intra-arrest blood gas analysis, performed within 10 min of resuscitation, was used to define different phenotypes. In total, 567 patients were included. Non-severe acidosis (pH\u22677.15) was associated with favourable neurological outcome (odds ratio [OR]: 4.60, 95% confidence interval [CI] 1.63\u201312.95; <jats:italic>p<\/jats:italic> value\u2009=\u20090.004) and survival (OR: 3.25, 95% CI 1.72\u20136.15; <jats:italic>p<\/jats:italic> value\u2009&lt;\u20090.001) in the multivariable logistic regression analyses. In the interaction analysis, normal blood gas phenotype (pH: 7.35\u20137.45, PCO<jats:sub>2<\/jats:sub>: 35\u201345 mm Hg, HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup> level: 22\u201326 mmol\/L)\u2009\u00d7\u2009TTI \u2266 6.3 min (OR: 20.40, 95% CI 2.53\u2013164.75; <jats:italic>p<\/jats:italic> value\u2009=\u20090.005) and non-severe acidosis\u2009\u00d7\u2009TTI \u2266 6.3 min (OR: 3.35, 95% CI 1.00\u201311.23; <jats:italic>p<\/jats:italic> value\u2009=\u20090.05) were associated with neurological recovery while metabolic acidosis\u2009\u00d7\u2009TTI \u2266 5.7 min (OR: 3.63, 95% CI 1.36\u20139.67; <jats:italic>p<\/jats:italic> value\u2009=\u20090.01) and hypercapnic acidosis\u2009\u00d7\u2009TTI \u2266 10.4 min (OR: 2.27, 95% CI 1.20\u20134.28; <jats:italic>p<\/jats:italic> value\u2009=\u20090.01) were associated with survival. Intra-arrest blood gas analysis may help guide TTI during for patients with IHCA.<\/jats:p>","DOI":"10.1038\/s41598-021-89920-y","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T10:04:35Z","timestamp":1621332275000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Blood gas phenotyping and tracheal intubation timing in adult in-hospital cardiac arrest: a retrospective cohort study"],"prefix":"10.1038","volume":"11","author":[{"given":"Chih-Hung","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Che","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Yi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Hua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Shan","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung-Chien","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Wen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Tien","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Jone","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"89920_CR1","doi-asserted-by":"publisher","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","volume":"135","author":"EJ Benjamin","year":"2017","unstructured":"Benjamin, E. 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