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The diurnal variation in urine volume, osmolality, and salt excretion were measured on preoperative day 2 and postoperative day 7. The factors associated with an increase in the nighttime urine volume rate with decreased renal function were evaluated using multiple linear regression analysis. Forty-nine patients were included. The estimated glomerular filtration rate decreased from 73.3\u2009\u00b1\u20092.0 to 47.2\u2009\u00b1\u20091.6\u00a0mL\/min\/1.73 m<jats:sup>2<\/jats:sup> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and the nighttime urine volume rate increased from 40.6%\u2009\u00b1\u20092.0% to 45.3%\u2009\u00b1\u20091.5% (<jats:italic>P<\/jats:italic>\u2009=\u20090.04) with nephrectomy. The nighttime urine osmolality decreased from 273\u2009\u00b1\u200915 to 212\u2009\u00b1\u200910\u00a0mOsm\/kg and the nighttime salt excretion rate increased from 38.7%\u2009\u00b1\u20092.1% to 48.8%\u2009\u00b1\u20091.7% (both <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) with nephrectomy. Multiple linear regression analysis showed that the increase in the nighttime urine volume rate was strongly affected by the increase in the nighttime salt excretion rate. A decrease in renal function causes an increase in the nighttime urine volume rate, mainly because of an increase in nighttime salt excretion.<\/jats:p><jats:p>Trial registration number: UMIN000036760 (University Hospital Medical Information Network Clinical Trials Registry).<\/jats:p><jats:p>Date of registration: From 1 June 2019 to 31 October 2020.<\/jats:p>","DOI":"10.1038\/s41598-021-90166-x","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T10:03:29Z","timestamp":1621418609000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime"],"prefix":"10.1038","volume":"11","author":[{"given":"Kentaro","family":"Takezawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohei","family":"Kuribayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Sekii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Inagaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Fukuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kiuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyofumi","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutoshi","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohide","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Nonomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"90166_CR1","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1002\/nau.23917","volume":"38","author":"H Hashim","year":"2019","unstructured":"Hashim, H. et al. 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