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Sixty mice were divided into six groups (n\u2009=\u200910, each), and these groups were imaged with 7.0\u00a0T multiparameter MRI and treated with an alternative CPZ administration schedule. T<jats:sub>2<\/jats:sub>-weighted imaging (T<jats:sub>2<\/jats:sub>WI), susceptibility-weighted imaging (SWI), and diffusion tensor imaging (DTI) were used to compare the splenium of the corpus callosum (sCC) among the groups. Prussian blue and Luxol fast blue staining were performed to assess pathology. The correlations of the mean grayscale value (mGSV) of the pathology results and the MRI metrics were analyzed to evaluate the multiparameter MRI results. One-way ANOVA and post hoc comparison showed that the normalized T<jats:sub>2<\/jats:sub>WI (T<jats:sub>2<\/jats:sub>-nor), fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) values were significantly different among the six groups, while the mean phase (\u03a6) value of SWI was not significantly different among the groups. Correlation analysis showed that the correlation between the T<jats:sub>2<\/jats:sub>-nor and mGSV was higher than that among the other values. The correlations among the FA, RD, MD, and mGSV remained instructive. 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