{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:37:28Z","timestamp":1792406248473,"version":"4.4.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81771534"],"award-info":[{"award-number":["81771534"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81771534"],"award-info":[{"award-number":["81771534"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We explored the independent risk factors associated with cases of spontaneous abortion in infertile patients treated with human-assisted reproductive technology (ART) and established a smooth curve fit and perform a threshold effect analysis can provide guidance and a valuable reference for predicting the probability of spontaneous abortion. This was a retrospective cohort study of 16,097 patients successfully conceived with ART in Shangqiu First People's Hospital from June 2013 to December 2018. Overall, 2,378 (14.77%) had an abortion and 13,719 (85.23%) did not have an abortion. Multivariate logistic regression analysis showed that female age (OR 1.050; 95% CI 1.032\u20131.069; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), male age (OR 1.100; 95% CI 1.086\u20131.115; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), follicular-stimulating hormone (OR 1.049; 95% CI 1.022\u20131.076; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), anti-Mullerian hormone (OR 0.893; 95% CI 0.862\u20130.925; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and the number of fetuses at pregnancy diagnosis were independent factors associated with spontaneous abortion. The threshold effect analysis found that when female age\u2009&gt;\u200932\u00a0years (cut-off point) old, age and the risk of spontaneous abortion were positively correlated. When follicular-stimulating hormone\u2009&gt;\u20096.1\u00a0IU\/L (cut-off point), follicular-stimulating hormone was positively correlated with the occurrence of spontaneous abortion, When anti-Mullerian hormone\u2009\u2264\u20093.1\u00a0ng\/mL (cut-off point), anti-Mullerian hormone was negatively correlated with the occurrence of spontaneous abortion and there was a linear positive correlation between antral Follicle Counting and live birth. In addition, the older the male age, the higher the incidence of abortion. The smooth curve fit and threshold effect analyses can provide a more detailed estimate of the probability of spontaneous abortion for pregnant couples.<\/jats:p>","DOI":"10.1038\/s41598-021-90970-5","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T10:05:58Z","timestamp":1622455558000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The threshold effect of factors associated with spontaneous abortion in human-assisted reproductive technology"],"prefix":"10.1038","volume":"11","author":[{"given":"Fei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AiQin","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XingMei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"90970_CR1","doi-asserted-by":"publisher","first-page":"3656","DOI":"10.1093\/eurheartj\/ehz609","volume":"40","author":"J Mehta","year":"2019","unstructured":"Mehta, J. Response to \u201cLate repercussions of assisted reproductive technology\u201d. Eur. Heart J. 40, 3656. https:\/\/doi.org\/10.1093\/eurheartj\/ehz609 (2019).","journal-title":"Eur. Heart J."},{"key":"90970_CR2","doi-asserted-by":"publisher","first-page":"5041","DOI":"10.12659\/msm.904500","volume":"23","author":"Q Xu","year":"2017","unstructured":"Xu, Q. et al. Sex hormone metabolism and threatened abortion. Med. Sci. Monit. Int. Med. J. Exp. Clin. Res. 23, 5041\u20135048. https:\/\/doi.org\/10.12659\/msm.904500 (2017).","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"90970_CR3","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1111\/ppe.12142","volume":"28","author":"K Hahn","year":"2014","unstructured":"Hahn, K. et al. Body size and risk of spontaneous abortion among danish pregnancy planners. Paediatr. Perinat. Epidemiol. 28, 412\u2013423. https:\/\/doi.org\/10.1111\/ppe.12142 (2014).","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"90970_CR4","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.ajog.2018.02.013","volume":"218","author":"S Daniel","year":"2018","unstructured":"Daniel, S., Rotem, R., Koren, G., Lunenfeld, E. & Levy, A. Vaginal antimycotics and the risk for spontaneous abortions. Am. J. Obstet. Gynecol. 218, 601\u2013607. https:\/\/doi.org\/10.1016\/j.ajog.2018.02.013 (2018).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"90970_CR5","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1093\/humrep\/deaa035","volume":"35","author":"H Wang","year":"2020","unstructured":"Wang, H. et al. Maternal spontaneous abortion and the risk of attention-deficit\/hyperactivity disorder in offspring: a population-based cohort study. Hum. Reprod. (Oxford, England) 35, 1211\u20131221. https:\/\/doi.org\/10.1093\/humrep\/deaa035 (2020).","journal-title":"Hum. Reprod. (Oxford, England)"},{"key":"90970_CR6","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/jlme.12240","volume":"43","author":"J Daar","year":"2015","unstructured":"Daar, J. Distinctions in disclosure: mandated informed consent in abortion and ART. J. Law Med. Ethics J. Am. Soc. Law Med. Ethics 43, 255\u2013258. https:\/\/doi.org\/10.1111\/jlme.12240 (2015).","journal-title":"J. Law Med. Ethics J. Am. Soc. Law Med. Ethics"},{"key":"90970_CR7","doi-asserted-by":"publisher","first-page":"011537","DOI":"10.1002\/14651858.CD011537.pub3","volume":"10","author":"L Craciunas","year":"2018","unstructured":"Craciunas, L., Tsampras, N., Raine-Fenning, N. & Coomarasamy, A. Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction. Cochrane Database Syst. Rev. 10, 011537. https:\/\/doi.org\/10.1002\/14651858.CD011537.pub3 (2018).","journal-title":"Cochrane Database Syst. Rev."},{"key":"90970_CR8","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1080\/14767058.2017.1330330","volume":"31","author":"R Dai","year":"2018","unstructured":"Dai, R. et al. Effect of maternal age on spontaneous abortion during the first trimester in Northeast China. J. Matern. Fetal. Neonatal. Med. 31, 1824\u20131829. https:\/\/doi.org\/10.1080\/14767058.2017.1330330 (2018).","journal-title":"J. Matern. Fetal. Neonatal. Med."},{"key":"90970_CR9","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1111\/j.1442-200X.2011.03331.x","volume":"53","author":"M Iwayama","year":"2011","unstructured":"Iwayama, M. et al. Parental age and child growth and development: child health check-up data. Pediatrics Int. Off. J. Japan Pediatric Soc. 53, 709\u2013714. https:\/\/doi.org\/10.1111\/j.1442-200X.2011.03331.x (2011).","journal-title":"Pediatrics Int. Off. J. Japan Pediatric Soc."},{"key":"90970_CR10","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1056\/NEJMoa1110238","volume":"366","author":"B Luke","year":"2012","unstructured":"Luke, B. et al. Cumulative birth rates with linked assisted reproductive technology cycles. N. Engl. J. Med. 366, 2483\u20132491. https:\/\/doi.org\/10.1056\/NEJMoa1110238 (2012).","journal-title":"N. Engl. J. Med."},{"key":"90970_CR11","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.1093\/humrep\/deaa208","volume":"35","author":"V Grzegorczyk-Martin","year":"2020","unstructured":"Grzegorczyk-Martin, V. et al. IVF outcomes in patients with a history of bariatric surgery: a multicenter retrospective cohort study. Hum. Reprod. (Oxford, England) 35, 2755\u20132762. https:\/\/doi.org\/10.1093\/humrep\/deaa208 (2020).","journal-title":"Hum. Reprod. (Oxford, England)"},{"key":"90970_CR12","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1056\/NEJMe1803491","volume":"378","author":"C Westhoff","year":"2018","unstructured":"Westhoff, C. A better medical regimen for the management of miscarriage. N. Engl. J. Med. 378, 2232\u20132233. https:\/\/doi.org\/10.1056\/NEJMe1803491 (2018).","journal-title":"N. Engl. J. Med."},{"key":"90970_CR13","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1016\/s0140-6736(17)32135-9","volume":"390","author":"K Gemzell-Danielsson","year":"2017","unstructured":"Gemzell-Danielsson, K. & Cleeve, A. Estimating abortion safety: advancements and challenges. Lancet (London, England) 390, 2333\u20132334. https:\/\/doi.org\/10.1016\/s0140-6736(17)32135-9 (2017).","journal-title":"Lancet (London, England)"},{"key":"90970_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10040197","author":"L Monteiro","year":"2020","unstructured":"Monteiro, L. et al. Increased circulating levels of tissue-type plasminogen activator are associated with the risk of spontaneous abortion during the first trimester of pregnancy. Diagnostics (Basel, Switzerland) https:\/\/doi.org\/10.3390\/diagnostics10040197 (2020).","journal-title":"Diagnostics (Basel, Switzerland)"},{"issue":"280","key":"90970_CR15","doi-asserted-by":"publisher","first-page":"e281","DOI":"10.1016\/j.ajog.2016.11.1042","volume":"216","author":"C Maignien","year":"2017","unstructured":"Maignien, C. et al. Prognostic factors for assisted reproductive technology in women with endometriosis-related infertility. Am. J. Obstet. Gynecol. 216(280), e281-280.e289. https:\/\/doi.org\/10.1016\/j.ajog.2016.11.1042 (2017).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"90970_CR16","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1210\/jc.2006-1123","volume":"92","author":"L Tian","year":"2007","unstructured":"Tian, L., Shen, H., Lu, Q., Norman, R. & Wang, J. Insulin resistance increases the risk of spontaneous abortion after assisted reproduction technology treatment. J. Clin. Endocrinol. Metab. 92, 1430\u20131433. https:\/\/doi.org\/10.1210\/jc.2006-1123 (2007).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"90970_CR17","first-page":"525","volume":"22","author":"J Hu","year":"2016","unstructured":"Hu, J., Xing, L., Wu, H., Zhu, W. & Fan, L. Safety of the offspring conceived by assisted reproductive technology with cryopreserved donor sperm. Zhonghua nan ke xue Natl. J. Androl. 22, 525\u2013529 (2016).","journal-title":"Zhonghua nan ke xue Natl. J. Androl."},{"key":"90970_CR18","doi-asserted-by":"publisher","first-page":"32","DOI":"10.5582\/bst.2017.01296","volume":"12","author":"Y Du","year":"2018","unstructured":"Du, Y. et al. Chromosomal karyotype in chorionic villi of recurrent spontaneous abortion patients. Biosci. Trends 12, 32\u201339. https:\/\/doi.org\/10.5582\/bst.2017.01296 (2018).","journal-title":"Biosci. Trends"},{"key":"90970_CR19","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.rbmo.2017.04.006","volume":"35","author":"I Vittrup","year":"2017","unstructured":"Vittrup, I., Petersen, G., Kamper-J\u00f8rgensen, M., Pinborg, A. & Schmidt, L. Male and female alcohol consumption and live birth after assisted reproductive technology treatment: a nationwide register-based cohort study. Reprod. Biomed. 35, 152\u2013160. https:\/\/doi.org\/10.1016\/j.rbmo.2017.04.006 (2017).","journal-title":"Reprod. Biomed."},{"key":"90970_CR20","doi-asserted-by":"publisher","first-page":"9153","DOI":"10.1038\/s41598-020-66155-x","volume":"10","author":"T Tan","year":"2020","unstructured":"Tan, T. et al. Novel approach using serum progesterone as a triage to guide management of patients with threatened miscarriage: a prospective cohort study. Sci. Rep. 10, 9153. https:\/\/doi.org\/10.1038\/s41598-020-66155-x (2020).","journal-title":"Sci. Rep."},{"key":"90970_CR21","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1038\/s41598-019-39259-2","volume":"9","author":"X Liu","year":"2019","unstructured":"Liu, X. et al. Urinary metabolic variation analysis during pregnancy and application in Gestational Diabetes Mellitus and spontaneous abortion biomarker discovery. Sci. Rep. 9, 2605. https:\/\/doi.org\/10.1038\/s41598-019-39259-2 (2019).","journal-title":"Sci. Rep."},{"key":"90970_CR22","doi-asserted-by":"publisher","first-page":"797","DOI":"10.3760\/cma.j.issn.0529-567x.2019.12.002","volume":"54","author":"J Shen","year":"2019","unstructured":"Shen, J. et al. Chromosome abnormality rate and related factors of spontaneous abortion in early pregnancy. Zhonghua Fu Chan Ke Za Zhi 54, 797\u2013802. https:\/\/doi.org\/10.3760\/cma.j.issn.0529-567x.2019.12.002 (2019).","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"90970_CR23","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.1093\/humrep\/des255","volume":"27","author":"A Ferraretti","year":"2012","unstructured":"Ferraretti, A. et al. Assisted reproductive technology in Europe, 2008: results generated from European registers by ESHRE. Hum. Reprod. (Oxford, England) 27, 2571\u20132584. https:\/\/doi.org\/10.1093\/humrep\/des255 (2012).","journal-title":"Hum. Reprod. (Oxford, England)"},{"issue":"476","key":"90970_CR24","doi-asserted-by":"publisher","first-page":"e471","DOI":"10.1016\/j.ajog.2019.05.028","volume":"221","author":"B Nguyen","year":"2019","unstructured":"Nguyen, B., Chang, E. & Bendikson, K. Advanced paternal age and the risk of spontaneous abortion: an analysis of the combined 2011\u20132013 and 2013\u20132015 National Survey of Family Growth. Am. J. Obstet. Gynecol. 221(476), e471-476.e477. https:\/\/doi.org\/10.1016\/j.ajog.2019.05.028 (2019).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"90970_CR25","doi-asserted-by":"publisher","first-page":"748","DOI":"10.12669\/pjms.293.3388","volume":"29","author":"R Jaleel","year":"2013","unstructured":"Jaleel, R. & Khan, A. Paternal factors in spontaneous first trimester miscarriage. Pakistan J. Med. Sci. 29, 748\u2013752. https:\/\/doi.org\/10.12669\/pjms.293.3388 (2013).","journal-title":"Pakistan J. Med. Sci."},{"key":"90970_CR26","doi-asserted-by":"publisher","first-page":"37","DOI":"10.4103\/2230-8210.107830","volume":"17","author":"S Kamalanathan","year":"2013","unstructured":"Kamalanathan, S., Sahoo, J. & Sathyapalan, T. Pregnancy in polycystic ovary syndrome. Indian J. Endocrinol. Metab. 17, 37\u201343. https:\/\/doi.org\/10.4103\/2230-8210.107830 (2013).","journal-title":"Indian J. Endocrinol. Metab."},{"key":"90970_CR27","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa010","author":"N du Foss\u00e9","year":"2020","unstructured":"du Foss\u00e9, N., van der Hoorn, M., van Lith, J., le Cessie, S. & Lashley, E. Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis. Hum. Reprod. Update https:\/\/doi.org\/10.1093\/humupd\/dmaa010 (2020).","journal-title":"Hum. Reprod. Update"},{"key":"90970_CR28","doi-asserted-by":"publisher","unstructured":"Frattarelli, J. L., Miller, K. A., Miller, B. T., Elkind-Hirsch, K. & Scott, R. T. Male age negatively impacts embryo development and reproductive outcome in donor oocyte art cycles. Fertil. Steril. 90, 97\u2013103. https:\/\/doi.org\/10.1016\/j.fertnstert.2007.06.009 (2007).\u00a0","DOI":"10.1016\/j.fertnstert.2007.06.009"},{"key":"90970_CR29","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1093\/aje\/kwi097","volume":"161","author":"R Slama","year":"2005","unstructured":"Slama, R. et al. Influence of paternal age on the risk of spontaneous abortion. Am. J. Epidemiol. 161, 816\u2013823. https:\/\/doi.org\/10.1093\/aje\/kwi097 (2005).","journal-title":"Am. J. Epidemiol."},{"key":"90970_CR30","doi-asserted-by":"publisher","first-page":"230","DOI":"10.5935\/1518-0557.20190028","volume":"23","author":"Z Basirat","year":"2019","unstructured":"Basirat, Z., Kashifard, M., Golsorkhtabaramiri, M. & Mirabi, P. Factors associated with spontaneous abortion following intracytoplasmic sperm injection (ICSI). JBRA Assist. Reprod. 23, 230\u2013234. https:\/\/doi.org\/10.5935\/1518-0557.20190028 (2019).","journal-title":"JBRA Assist. Reprod."},{"key":"90970_CR31","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.fertnstert.2019.03.022","volume":"112","author":"S Ligon","year":"2019","unstructured":"Ligon, S., Lustik, M., Levy, G. & Pier, B. Low antim\u00fcllerian hormone (AMH) is associated with decreased live birth after in vitro fertilization when follicle-stimulating hormone and AMH are discordant. Fertil. Steril. 112, 73-81.e71. https:\/\/doi.org\/10.1016\/j.fertnstert.2019.03.022 (2019).","journal-title":"Fertil. Steril."},{"key":"90970_CR32","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1007\/s10815-013-0077-z","volume":"30","author":"Z Merhi","year":"2013","unstructured":"Merhi, Z., Zapantis, A., Berger, D. & Jindal, S. Determining an anti-Mullerian hormone cutoff level to predict clinical pregnancy following in vitro fertilization in women with severely diminished ovarian reserve. J. Assist. Reprod. Genet. 30, 1361\u20131365. https:\/\/doi.org\/10.1007\/s10815-013-0077-z (2013).","journal-title":"J. Assist. Reprod. Genet."},{"key":"90970_CR33","doi-asserted-by":"publisher","first-page":"215","DOI":"10.5935\/1518-0557.20180043","volume":"22","author":"J Scheffer","year":"2018","unstructured":"Scheffer, J. et al. Are age and anti-M\u00fcllerian hormone good predictors of ovarian reserve and response in women undergoing IVF?. JBRA Assist. Reprod. 22, 215\u2013220. https:\/\/doi.org\/10.5935\/1518-0557.20180043 (2018).","journal-title":"JBRA Assist. Reprod."},{"key":"90970_CR34","first-page":"281","volume":"9","author":"A Aflatoonian","year":"2011","unstructured":"Aflatoonian, A., Eftekhar, M., Mohammadian, F. & Yousefnejad, F. Outcome of assisted reproductive technology in women aged 40 years and older. Iran. J. Reprod. Med. 9, 281\u2013284 (2011).","journal-title":"Iran. J. Reprod. Med."},{"key":"90970_CR35","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1016\/j.fertnstert.2016.01.001","volume":"105","author":"M Atasever","year":"2016","unstructured":"Atasever, M., Soyman, Z., Demirel, E., Gencdal, S. & Kelekci, S. Diminished ovarian reserve: is it a neglected cause in the assessment of recurrent miscarriage? A cohort study. Fertil. Steril. 105, 1236\u20131240. https:\/\/doi.org\/10.1016\/j.fertnstert.2016.01.001 (2016).","journal-title":"Fertil. Steril."},{"key":"90970_CR36","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.rbmo.2019.12.014","volume":"40","author":"R Zemet","year":"2020","unstructured":"Zemet, R. et al. Pregnancy outcome after multifetal pregnancy reduction of triplets to twins versus reduction to singletons. Reprod. Biomed. 40, 445\u2013452. https:\/\/doi.org\/10.1016\/j.rbmo.2019.12.014 (2020).","journal-title":"Reprod. Biomed."},{"key":"90970_CR37","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1080\/09513590.2019.1594762","volume":"35","author":"S Wang","year":"2019","unstructured":"Wang, S., Chen, L., Fang, J., Jiang, W. & Zhang, N. Comparison of the pregnancy and obstetric outcomes between single cleavage-stage embryo transfer and single blastocyst transfer by time-lapse selection of embryos. Gynecol. Endocrinol. Off. J. Int. Soc. Gynecol. Endocrinol. 35, 792\u2013795. https:\/\/doi.org\/10.1080\/09513590.2019.1594762 (2019).","journal-title":"Gynecol. Endocrinol. Off. J. Int. Soc. Gynecol. Endocrinol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-90970-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-90970-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-90970-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T09:00:41Z","timestamp":1670058041000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-90970-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,31]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["90970"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-90970-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,31]]},"assertion":[{"value":"30 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"11368"}}