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Tobacco smoke is a main indoor source of NO<jats:sub>x<\/jats:sub>, but little information is available about their concentrations in second-hand smoke (SHS), particularly in small indoors. This study presents data of NO<jats:sub>x<\/jats:sub> and its main components nitric oxide (NO) and NO<jats:sub>2<\/jats:sub> in SHS emitted by ten different cigarette brands measured in a closed test chamber with a volume of 2.88 m<jats:sup>3<\/jats:sup>, similar to the volume of vehicle cabins. The results show substantial increases in NO<jats:sub>x<\/jats:sub> concentrations when smoking only one cigarette. The NO<jats:sub>2<\/jats:sub> mean concentrations ranged between 105 and 293\u00a0\u00b5g\/m<jats:sup>3<\/jats:sup>, the NO<jats:sub>2<\/jats:sub> peak concentrations between 126 and 357\u00a0\u00b5g\/m<jats:sup>3<\/jats:sup>. That means the one-hour mean guideline of 200\u00a0\u00b5g\/m<jats:sup>3<\/jats:sup> for NO<jats:sub>2<\/jats:sub> of the World Health Organization was exceeded up to 47%, respectively 79%. The measured NO<jats:sub>2<\/jats:sub> values show positive correlations with the values for tar, nicotine, and carbon monoxide stated by the cigarette manufacturers. This study provides NO<jats:sub>2<\/jats:sub> concentrations in SHS at health hazard levels. These data give rise to the necessity of health authorities\u2019 measures to inform about and caution against NO<jats:sub>x<\/jats:sub> exposure by smoking in indoor rooms.<\/jats:p>","DOI":"10.1038\/s41598-021-90994-x","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T10:15:03Z","timestamp":1622715303000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The impact of second-hand smoke on nitrogen oxides concentrations in a small interior"],"prefix":"10.1038","volume":"11","author":[{"given":"Markus","family":"Braun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Klingelh\u00f6fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Groneberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,3]]},"reference":[{"key":"90994_CR1","unstructured":"WHO. 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