{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T20:07:43Z","timestamp":1779048463188,"version":"3.51.4"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004442","name":"National Science Centre","doi-asserted-by":"crossref","award":["2014\/15\/B\/N25\/03572"],"award-info":[{"award-number":["2014\/15\/B\/N25\/03572"]}],"id":[{"id":"10.13039\/501100004442","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004382","name":"Polish Academy of Sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004382","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Uterine inflammation is a very common and serious condition in domestic animals. To development and progression of this pathology often lead disturbances in myometrial contractility. Participation of \u03b21-, \u03b22- and \u03b23-adrenergic receptors (ARs) in noradrenaline (NA)-influenced contractility of the pig inflamed uterus was studied. The gilts of SAL- and <jats:italic>E.coli<\/jats:italic>-treated groups were administered saline or <jats:italic>E.coli<\/jats:italic> suspension into the uterine horns, respectively. Laparotomy was only done in the CON group. Compared to the period before NA administration, this neurotransmitter reduced the tension, amplitude and frequency in uterine strips of the CON and SAL groups. In the <jats:italic>E.coli<\/jats:italic> group, NA decreased the amplitude and frequency, and these parameters were lower than in other groups. In the CON, SAL and <jats:italic>E.coli<\/jats:italic> groups, \u03b21- and \u03b23-ARs antagonists in more cases did not significantly change and partly eliminated NA inhibitory effect on amplitude and frequency, as compared to NA action alone. In turn, \u03b22-ARs antagonist completely abolished NA relaxatory effect on these parameters in three groups. Summarizing, NA decreases the contractile amplitude and frequency of pig inflamed uterus via all \u03b2-ARs subtypes, however, \u03b22-ARs have the greatest importance. Given this, pharmacological modulation of particular \u03b2-ARs subtypes can be used to increase inflamed uterus contractility.<\/jats:p>","DOI":"10.1038\/s41598-021-91184-5","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T15:20:18Z","timestamp":1622560818000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Role of beta-adrenergic receptor subtypes in pig uterus contractility with inflammation"],"prefix":"10.1038","volume":"11","author":[{"given":"Barbara","family":"Jana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaros\u0142aw","family":"Ca\u0142ka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"91184_CR1","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1093\/humrep\/13.7.1968","volume":"13","author":"R Fanchin","year":"1998","unstructured":"Fanchin, R. et al. Uterine contractions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization. Hum. Reprod. 13, 1968\u20131974 (1998).","journal-title":"Hum. Reprod."},{"key":"91184_CR2","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1114\/1.181","volume":"27","author":"O Eytan","year":"1999","unstructured":"Eytan, O., Jaffa, A. J., Har-Toov, J., Dalach, E. & Elad, D. Dynamics of the intrauterine fluid-wall interface. Ann. Biomed. Eng. 27, 372\u2013379 (1999).","journal-title":"Ann. Biomed. Eng."},{"key":"91184_CR3","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s13028-015-0175-2","volume":"57","author":"R Mordak","year":"2015","unstructured":"Mordak, R. & Stewart, P. A. Periparturient stress and immune suppression as a potential cause of retained placenta in highly productive dairy cows: examples of prevention. Acta Vet. Scand. 57, 84 (2015).","journal-title":"Acta Vet. Scand."},{"key":"91184_CR4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s13028-016-0201-z","volume":"58","author":"W Markiewicz","year":"2016","unstructured":"Markiewicz, W., Bogacki, M., Blitek, M. & Jaroszewski, J. J. Comparison of the porcine uterine smooth muscle contractility on days 12\u201314 of the estrous cycle and pregnancy. Acta Vet. Scand. 58, 20 (2016).","journal-title":"Acta Vet. Scand."},{"key":"91184_CR5","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s00580-009-0929-1","volume":"19","author":"P Tummaruk","year":"2010","unstructured":"Tummaruk, P., Kesdangsakonwut, S., Prapasarakul, N. & Kaeoket, K. Endometritis in gilts: reproductive data, bacterial culture, histopathology, and infiltration of immune cells in the endometrium. Comp. Clin. Pathol. 19, 575\u2013584 (2010).","journal-title":"Comp. Clin. Pathol."},{"key":"91184_CR6","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1177\/1933719112446084","volume":"20","author":"O Shynlova","year":"2013","unstructured":"Shynlova, O., Lee, Y. H., Srikhajon, K. & Lye, S. J. Physiologic uterine inflammation and labor onset: integration of endocrine and mechanical signals. Reprod. Sci. 20, 154\u2013167 (2013).","journal-title":"Reprod. Sci."},{"key":"91184_CR7","doi-asserted-by":"publisher","first-page":"109","DOI":"10.17236\/sat00105","volume":"159","author":"W Pendl","year":"2017","unstructured":"Pendl, W. et al. Effect of herd health management on the prevalence of Postpartum Dysgalaktie Syndrome (PPDS) and the treatment incidence. Schweiz. Arch. Tierheilkd. 159, 109\u2013116 (2017).","journal-title":"Schweiz. Arch. Tierheilkd."},{"key":"91184_CR8","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.2527\/1997.7561621x","volume":"75","author":"A Ramadan","year":"1997","unstructured":"Ramadan, A., Johnson, G. I. & Lewis, D. Regulation of the uterine immune function during the estrous cycle and in response to infection bacteria in sheep. J. Anim. Sci. 75, 1621\u20131632 (1997).","journal-title":"J. Anim. Sci."},{"key":"91184_CR9","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1262\/jrd.2015-015","volume":"61","author":"M Heppelmann","year":"2015","unstructured":"Heppelmann, M. et al. The effect of metritis and subclinical hypocalcemia on uterine involution in dairy cows evaluated by sonomicrometry. J. Reprod. Dev. 61, 565\u2013569 (2015).","journal-title":"J. Reprod. Dev."},{"key":"91184_CR10","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jri.2016.07.002","volume":"119","author":"IM Sheldon","year":"2017","unstructured":"Sheldon, I. M., Owens, S. E. & Turner, M. L. Innate immunity and the sensing of infection, damage and danger in the female genital tract. J. Reprod. Immunol. 119, 67\u201373 (2017).","journal-title":"J. Reprod. Immunol."},{"key":"91184_CR11","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1474-8673.1994.tb00603.x","volume":"14","author":"T Taneike","year":"1994","unstructured":"Taneike, T. et al. Muscle layer and regional differences in autonomic innervation and responsiveness to transmitter agents in swine myometrium. J. Auton. Pharmacol. 14, 213\u2013227 (1994).","journal-title":"J. Auton. Pharmacol."},{"key":"91184_CR12","first-page":"1103","volume":"46","author":"XTP Glock","year":"2005","unstructured":"Glock, X. T. P. & Bilkei, G. The effect of postparturient urogenital diseases on the lifetime reproductive performance of sows. Can. Vet. J. 46, 1103\u20131107 (2005).","journal-title":"Can. Vet. J."},{"key":"91184_CR13","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.2174\/1381612043383926","volume":"10","author":"F Hertelendy","year":"2004","unstructured":"Hertelendy, F. & Zakar, T. Regulation of myometrial smooth muscle functions. Curr. Pharm. Des. 10, 2499\u20132517 (2004).","journal-title":"Curr. Pharm. Des."},{"key":"91184_CR14","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13028-017-0300-5","volume":"59","author":"M Domino","year":"2017","unstructured":"Domino, M., Pawlinski, B., Zabielski, R. & Gajewski, Z. C-kit receptor immunopositive interstitial cells (Cajal-type) in the porcine reproductive tract. Acta Vet. Scand. 59, 32 (2017).","journal-title":"Acta Vet. Scand."},{"key":"91184_CR15","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1530\/rep.0.1220275","volume":"122","author":"SE Bae","year":"2001","unstructured":"Bae, S. E., Corcoran, B. M. & Watson, E. D. Immunohistochemical study of the distribution of adrenergic and peptidergic innervation in the equine uterus and the cervix. Reproduction 122, 275\u2013282 (2001).","journal-title":"Reproduction"},{"key":"91184_CR16","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1007\/s12640-019-00013-1","volume":"35","author":"L Rytel","year":"2019","unstructured":"Rytel, L., Gonkowski, S., Janowski, T., Wojtkiewicz, J. & Pomianowski, A. The neurochemical characterization of parasympathetic nerve fibres in the porcine wall under physiological conditons and after exposure to bisphenol A (BPA). Neurotox. Res. 35, 867\u2013882 (2019).","journal-title":"Neurotox. Res."},{"key":"91184_CR17","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1124\/pr.56.1.2","volume":"56","author":"SL Kirstein","year":"2004","unstructured":"Kirstein, S. L. & Insel, P. A. Autonomic nervous system pharmacogenomics: a progress report. Pharmacol. Rev. 56, 31\u201352 (2004).","journal-title":"Pharmacol. Rev."},{"key":"91184_CR18","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/0014-2999(93)90386-V","volume":"250","author":"JM Haynes","year":"1993","unstructured":"Haynes, J. M., Adams, G. D. & Pennefather, J. N. Alpha 2-adrenoceptors in the guinea-pig uterus: heterogeneity in the circular and longitudinal smooth muscle layers. Eur. J. Pharmacol. 250, 231\u2013237 (1993).","journal-title":"Eur. J. Pharmacol."},{"key":"91184_CR19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1474-8673.1995.tb00295.x","volume":"15","author":"T Taneike","year":"1995","unstructured":"Taneike, T. et al. Binding and functional characterization of alpha-2 adrenoceptors in isolated swine myometrium. J. Auton. Pharmacol. 15, 93\u2013105 (1995).","journal-title":"J. Auton. Pharmacol."},{"key":"91184_CR20","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S0014-2999(01)01504-7","volume":"433","author":"T Kitazawa","year":"2001","unstructured":"Kitazawa, T., Nakagoshi, K., Teraoka, H. & Taneike, T. 5-HT(7) receptor and beta(2)-adrenoceptor share in the inhibition of porcine uterine contractility in a muscle layer-dependent manner. Eur. J. Pharmacol. 433, 187\u2013197 (2001).","journal-title":"Eur. J. Pharmacol."},{"key":"91184_CR21","doi-asserted-by":"crossref","unstructured":"Ontsouka, E. C., Reist, M., Graber, H., Blum, J. W., Steiner, A. et al. Expression of messenger RNA coding for 5-HT receptor, alpha and beta adrenoreceptor (subtypes) during oestrus and dioestrus in the bovine uterus. J. Vet. Med. A Physiol. Pathol. Clin. Med. 51, 385\u2013393 (2004).","DOI":"10.1111\/j.1439-0442.2004.00667.x"},{"key":"91184_CR22","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.1186\/1471-2393-7-S1-S14","volume":"7","author":"M Bardou","year":"2007","unstructured":"Bardou, M. et al. Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?. BMC Pregnancy Childbirth. 7, S14 (2007).","journal-title":"BMC Pregnancy Childbirth."},{"key":"91184_CR23","first-page":"918","volume":"82","author":"A Pedzi\u0144ska-Betiuk","year":"2011","unstructured":"Pedzi\u0144ska-Betiuk, A., Modzelewska, B., J\u00f3\u017awik, M., J\u00f3\u017awik, M. & Kostrzewska, A. Differences in the effects of beta2- and beta3-adrenoceptor agonists on spontaneous contractions of human nonpregnant myometrium. Ginekol Pol. 82, 918\u2013924 (2011).","journal-title":"Ginekol Pol."},{"key":"91184_CR24","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1530\/REP-09-0116","volume":"138","author":"R Minorics","year":"2009","unstructured":"Minorics, R., G\u00e1sp\u00e1r, R., G\u00e1l, A., Klukovits, A. & Falkay, G. Progesterone decreases the relaxing effect of the beta3-adrenergic receptor agonist BRL 37344 in the pregnant rat myometrium. Reproduction 138, 383\u2013390 (2009).","journal-title":"Reproduction"},{"key":"91184_CR25","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1159\/000332393","volume":"73","author":"T Kaya","year":"2012","unstructured":"Kaya, T., Karadas, B., Altun, A., Sarac, \u0130 & Bagcivan, I. Effects and selectivity of CL 316243, beta-3-adrenoceptor agonist, in term-pregnant rat myometrium. Gynecol. Obstet. Invest. 73, 63\u201369 (2012).","journal-title":"Gynecol. Obstet. Invest."},{"key":"91184_CR26","doi-asserted-by":"publisher","first-page":"4611","DOI":"10.2527\/jas.2016-0577","volume":"94","author":"W Markiewicz","year":"2016","unstructured":"Markiewicz, W. & Jaroszewski, J. J. \u03b2- and \u03b2-adrenergic receptors stimulation relaxes porcine myometrium in the peri-implantation period. J. Anim. Sci. 94, 4611\u20134618 (2016).","journal-title":"J. Anim. Sci."},{"key":"91184_CR27","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1515\/pjvs-2017-0015","volume":"20","author":"W Markiewicz","year":"2017","unstructured":"Markiewicz, W. & Jaroszewski, J. J. Influence of \u03b22- and \u03b23-adrenoceptor agonists on contractile activity of the porcine myometrium in the luteal phase and the first days of pregnancy. Pol. J. Vet. Sci. 20, 111\u2013121 (2017).","journal-title":"Pol. J. Vet. Sci."},{"key":"91184_CR28","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1211\/0022357055768","volume":"57","author":"K Nandakumar","year":"2005","unstructured":"Nandakumar, K. et al. Selective beta(1)-adrenoreceptor blocking activity of newly synthesized acyl amino-substituted aryloxypropanolamine derivatives, DPJ 955 and DPJ 890, in rats. J. Pharm. Pharmacol. 57, 515\u2013519 (2005).","journal-title":"J. Pharm. Pharmacol."},{"key":"91184_CR29","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.ejphar.2012.11.048","volume":"700","author":"S Parida","year":"2013","unstructured":"Parida, S., Uttam Singh, T., Ravi Prakash, V. & Mishra, S. K. Molecular and functional characteristics of \u03b23-adrenoceptors in late pregnant mouse uterus: a comparison with \u03b22-adrenoceptors. Eur. J. Pharmacol. 700, 74\u201379 (2013).","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"91184_CR30","doi-asserted-by":"publisher","first-page":"891","DOI":"10.3390\/ani10050891","volume":"10","author":"B Jana","year":"2020","unstructured":"Jana, B. & Ca\u0142ka, J. Endometritis changes the neurochemical characteristics of the caudal mesenteric ganglion neurons supplying the gilt uterus. Animals (Basel). 10(5), 891 (2020).","journal-title":"Animals (Basel)."},{"key":"91184_CR31","first-page":"629","volume":"61","author":"G Csik","year":"2010","unstructured":"Csik, G., Spiegl, G., Minorics, R., Falkay, G. & Zupko, I. The effects of adjuvant arthritis on the myometrial adrenergic functions in the nonpregnant and the late-pregnant rat. J. Physiol. Pharmacol. 61, 629\u2013636 (2010).","journal-title":"J. Physiol. Pharmacol."},{"key":"91184_CR32","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.theriogenology.2012.10.020","volume":"79","author":"B Jana","year":"2013","unstructured":"Jana, B., Jaroszewski, J. J., Czarzasta, J., W\u0142odarczyk, M. & Markiewicz, W. Synthesis of prostacyclin and its effect on the contractile activity of the inflamed porcine uterus. Theriogenology 79, 470\u2013485 (2013).","journal-title":"Theriogenology"},{"key":"91184_CR33","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.theriogenology.2018.06.025","volume":"119","author":"KA Meller","year":"2018","unstructured":"Meller, K. A., Ca\u0142ka, J., Kaczmarek, M. & Jana, B. Expression of alpha and beta adrenergic receptors in the pig uterus during inflammation. Theriogenology 119, 96\u2013104 (2018).","journal-title":"Theriogenology"},{"key":"91184_CR34","first-page":"11","volume":"3","author":"GJ Dejneka","year":"2004","unstructured":"Dejneka, G. J., Dejneka, J., Kozdrowski, R., Rau\u0142uszkiewicz, S. & Twardo\u0144, J. Effect of intrauteine infusion of the propranolol on the uterus motility in cows after parturition. Acta Sci. Pol. Med. Vet. 3, 11\u201318 (2004).","journal-title":"Acta Sci. Pol. Med. Vet."},{"key":"91184_CR35","first-page":"69","volume":"32","author":"S Bademkiran","year":"2006","unstructured":"Bademkiran, S. & Kaya, H. H. Comparison of the betareceptor blockers (carazolol) and PGF2\u03b1 to prevent the retained placenta in cows due to dystocia. Istambul Univ. Fac. Vet. Med. 32, 69\u201379 (2006).","journal-title":"Istambul Univ. Fac. Vet. Med."},{"key":"91184_CR36","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0093-691X(83)90214-5","volume":"20","author":"H Bostedt","year":"1993","unstructured":"Bostedt, H. & Rudloff, P. R. Prophylactic administration of the beta-blocker carazolol to influence the duration of parturition in sows. Theriogenology 20, 191\u2013196 (1993).","journal-title":"Theriogenology"},{"key":"91184_CR37","first-page":"29","volume":"7","author":"R Kirkwood","year":"1999","unstructured":"Kirkwood, R. Pharmacological intervention in swine reproduction. J. Swine Health Prod. 7, 29\u201335 (1999).","journal-title":"J. Swine Health Prod."},{"key":"91184_CR38","unstructured":"Sabuncu, A., Tec, C., Bademkiran, S., Kasikci, G., Horoz Kaya, H. et al. Effect of beta adrenergic blocker carazolol on the duration of parturition in gilts. Indian Vet. J. 85, 21\u201322 (2008)."},{"key":"91184_CR39","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.anireprosci.2006.01.002","volume":"97","author":"B Jana","year":"2007","unstructured":"Jana, B., Kucharski, J., Dzienis, A. & Deptu\u0142a, K. Changes in prostaglandin production and ovarian function in gilts during endometritis induced by Escherichia coli infection. Anim. Reprod. Sci. 97, 137\u2013150 (2007).","journal-title":"Anim. Reprod. Sci."},{"key":"91184_CR40","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1071\/RD13191","volume":"26","author":"B Jana","year":"2014","unstructured":"Jana, B., Czarzasta, J. & Jaroszewski, J. Synthesis of leukotrienes in porcine uteri with endometritis induced by infection with Escherichia coli. Reprod. Fertil. Dev. 26, 1007\u20131016 (2014).","journal-title":"Reprod. Fertil. Dev."},{"key":"91184_CR41","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/S0002-9378(85)80076-4","volume":"152","author":"L Quaas","year":"1985","unstructured":"Quaas, L. & Zahradnik, P. The effects of alpha- and beta-adrenergic stimulation on contractility and prostaglandin (prostaglandins E2 and F2a and 6-keto-prostaglandin F1 alpha) production of pregnant human myometrial strips. Am. J. Obstel. Gynecol. 152, 852\u2013856 (1985).","journal-title":"Am. J. Obstel. Gynecol."},{"key":"91184_CR42","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.theriogenology.2019.09.015","volume":"143","author":"B Jana","year":"2020","unstructured":"Jana, B., Ca\u0142ka, J., Bulc, M. & Piotrowska-Tomala, K. K. Participation of acetylcholine and its receptors in the contractility of inflamed porcine uterus. Theriogenology 143, 123\u2013132 (2020).","journal-title":"Theriogenology"},{"key":"91184_CR43","doi-asserted-by":"publisher","first-page":"e0236044","DOI":"10.1371\/journal.pone.0236044","volume":"15","author":"B Jana","year":"2020","unstructured":"Jana, B., Ca\u0142ka, J. & Palus, K. Inflammation changes the expression of neuropeptide Y receptors in the pig myometrium and their role in the uterine contractility. PLoS ONE 15, e0236044 (2020).","journal-title":"PLoS ONE"},{"key":"91184_CR44","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.rvsc.2020.09.016","volume":"133","author":"B Jana","year":"2020","unstructured":"Jana, B., Ca\u0142ka, J. & Czajkowska, M. The role of somatostatin and its receptors (sstr2, sstr5) in the contractility of gilt inflamed uterus. Res. Vet. Sci. 133, 163\u2013173 (2020).","journal-title":"Res. Vet. Sci."},{"key":"91184_CR45","doi-asserted-by":"publisher","first-page":"106680","DOI":"10.1016\/j.anireprosci.2020.106680","volume":"225","author":"K Palus","year":"2021","unstructured":"Palus, K., Ca\u0142ka, J. & Jana, B. Alterations in the relative abundance of the vasoactive intestinal peptide receptors (VPAC1 and VPAC2) and functions in uterine contractility during inflammation. Anim. Reprod. Sci. 225, 106680 (2021).","journal-title":"Anim. Reprod. Sci."},{"key":"91184_CR46","doi-asserted-by":"publisher","first-page":"335","DOI":"10.2754\/avb201079020335","volume":"79","author":"B Jana","year":"2010","unstructured":"Jana, B. et al. Participation of prostaglandin E2 in contractile activity of inflamed porcine uterus. Acta Vet. Brno. 79, 335\u2013345 (2010).","journal-title":"Acta Vet. Brno."},{"key":"91184_CR47","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1095\/biolreprod60.2.277","volume":"60","author":"DJ Skarzynski","year":"1999","unstructured":"Skarzynski, D. J., Uenoyama, Y., Kotwica, J. & Okuda, K. Noradrenaline stimulates the production of prostaglandin f2alpha in cultured bovine endometrial cells. Biol. Reprod. 60, 277\u2013282 (1999).","journal-title":"Biol. Reprod."},{"key":"91184_CR48","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1742-2094-7-2","volume":"7","author":"JC Schlachetzki","year":"2010","unstructured":"Schlachetzki, J. C. et al. Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia. J. Neuroinflamm. 7, 2 (2010).","journal-title":"J. Neuroinflamm."},{"key":"91184_CR49","first-page":"953","volume":"247","author":"DL Lawson","year":"1988","unstructured":"Lawson, D. L., Smith, C., Mehta, J. L., Mehta, P. & Nichols, W. W. Leukotriene D4 potentiates the contractile effects of epinephrine and norepinephrine on rat aortic rings. J. Pharmacol. Exp. Ther. 247, 953\u2013957 (1988).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"91184_CR50","first-page":"29","volume":"55","author":"F Stanke-Labesque","year":"2000","unstructured":"Stanke-Labesque, F., Cracowski, J. L., Devillier, P. & Bessard, G. In vitro study of of the effects of cysteinyl leukotrienes on human vascular preparations. Therapie. 55, 29\u201333 (2000).","journal-title":"Therapie."},{"key":"91184_CR51","doi-asserted-by":"publisher","first-page":"654","DOI":"10.22358\/jafs\/66822\/2007","volume":"16","author":"J Kucharski","year":"2007","unstructured":"Kucharski, J. et al. The influence of inflammatory process on prostaglandin F2\u03b1 contractile activity in porcine uterus. J. Anim. Feed Sci. 16, 654\u2013667 (2007).","journal-title":"J. Anim. Feed Sci."},{"key":"91184_CR52","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/j.theriogenology.2015.01.021","volume":"83","author":"B Jana","year":"2015","unstructured":"Jana, B., Jaroszewski, J. J., Czarzasta, J. & Markiewicz, W. The influence of leukotrienes C4 and D4 on the contractility of an inflamed porcine uterus. Theriogenology 83, 1328\u20131337 (2015).","journal-title":"Theriogenology"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-91184-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-91184-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-91184-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T08:57:40Z","timestamp":1670057860000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-91184-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["91184"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-91184-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,1]]},"assertion":[{"value":"17 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"11512"}}