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These episodes of hypoxia and associated arousals from sleep induce physiological stress and nocturnal over-activation of the sympathetic nervous system (SNS). One consequence of OSA is impairment in a range of cognitive domains. Previous research into cognitive impairment in OSA have focussed on intermittent hypoxia and disrupted sleep, but not nocturnal over-activation of the SNS. Therefore, we investigated whether nocturnal over-activity of the SNS was associated with cognitive impairments in OSA. The extent of nocturnal SNS activation was estimated from heart rate variability (HRV), pulse wave amplitude (PWA) and stress response biomarkers (cortisol and glucose levels). OSA severity was significantly associated with PWA indices and the HRV low frequency\/ high frequency ratio (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Morning blood glucose levels were significantly associated with the duration of a blood oxygen saturation (SaO\n                    <jats:sub>2<\/jats:sub>\n                    )\u2009&lt;\u200990% (p\u2009&lt;\u20090.01). PWA and HRV were significantly associated with the time taken to perform a task involving visuospatial functioning (p\u2009&lt;\u20090.05), but not with impairments in sustained attention, reaction time or autobiographical memory. These results suggest that the visuospatial dysfunction observed in people with OSA is associated with increased nocturnal activity of the SNS.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-91329-6","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T06:06:06Z","timestamp":1623045966000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Association between nocturnal activity of the sympathetic nervous system and cognitive dysfunction in obstructive sleep apnoea"],"prefix":"10.1038","volume":"11","author":[{"given":"Ridwan M.","family":"Alomri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard A.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siraj Omar","family":"Wali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faris","family":"Alhejaili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,7]]},"reference":[{"key":"91329_CR1","doi-asserted-by":"publisher","first-page":"357","DOI":"10.3389\/fpsyt.2018.00357","volume":"9","author":"RG Bilyukov","year":"2018","unstructured":"Bilyukov, R. 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