{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T03:45:04Z","timestamp":1784432704032,"version":"3.55.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P20GM113123"],"award-info":[{"award-number":["P20GM113123"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01AI121804"],"award-info":[{"award-number":["R01AI121804"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite their protective antimicrobial function, neutrophil extracellular traps (NETs) have been implicated in propagation of inflammatory responses in several disease conditions including sepsis. Highly diffusible exogenous ROS produced under such inflammatory conditions, can induce exuberant NETs, thus making inhibition of NETs desirable in inflammatory diseases. Here we report that helminth parasite excretory\/secretory factors termed as parasitic ligands (PL) inhibit ROS-induced NETs by blocking the activation of nonselective calcium permeable channel Transient Receptor Potential Melastatin 2 (TRPM2). Therapeutic implication of PL mediated blockage of NET formation was tested in preclinical model of septic peritonitis, where PL treatment regulated neutrophil cell death modalities including NET formation and mitigated neutrophil mediated inflammatory response. This translated into improved survival and reduced systemic and local bacterial load in infected mice. Overall, our results posit PL as an important biological regulator of neutrophil functions with implications to a variety of inflammatory diseases including peritonitis.<\/jats:p>","DOI":"10.1038\/s41598-021-92001-9","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T10:03:04Z","timestamp":1623837784000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Helminth derived factors inhibit neutrophil extracellular trap formation and inflammation in bacterial peritonitis"],"prefix":"10.1038","volume":"11","author":[{"given":"Arun","family":"Chauhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitendra K.","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod","family":"Sukumran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brij B.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibhuti B.","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotika","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"92001_CR1","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.it.2019.05.001","volume":"40","author":"M Phillipson","year":"2019","unstructured":"Phillipson, M. & Kubes, P. The healing power of neutrophils. Trends Immunol. 40, 635\u2013647 (2019).","journal-title":"Trends Immunol."},{"key":"92001_CR2","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.it.2019.04.012","volume":"40","author":"C Silvestre-Roig","year":"2019","unstructured":"Silvestre-Roig, C., Fridlender, Z. G., Glogauer, M. & Scapini, P. Neutrophil diversity in health and disease. Trends Immunol. 40, 565\u2013583 (2019).","journal-title":"Trends Immunol."},{"key":"92001_CR3","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1182\/blood-2018-11-844530","volume":"133","author":"FVS Castanheira","year":"2019","unstructured":"Castanheira, F. V. S. & Kubes, P. Neutrophils and NETs in modulating acute and chronic inflammation. Blood 133, 2178\u20132185 (2019).","journal-title":"Blood"},{"key":"92001_CR4","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","volume":"303","author":"V Brinkmann","year":"2004","unstructured":"Brinkmann, V. et al. Neutrophil extracellular traps kill bacteria. Science 303, 1532\u20131535 (2004).","journal-title":"Science"},{"key":"92001_CR5","first-page":"20","volume":"20","author":"V Papayannopoulos","year":"2017","unstructured":"Papayannopoulos, V. Neutrophil extracellular traps in immunity and disease. Nat. Rev. Immunol. 20, 20 (2017).","journal-title":"Nat. Rev. Immunol."},{"key":"92001_CR6","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3389\/fimmu.2016.00236","volume":"7","author":"AS Kimball","year":"2016","unstructured":"Kimball, A. S., Obi, A. T., Diaz, J. A. & Henke, P. K. The emerging role of NETs in venous thrombosis and immunothrombosis. Front. Immunol. 7, 236 (2016).","journal-title":"Front. Immunol."},{"key":"92001_CR7","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1016\/j.autrev.2017.09.012","volume":"16","author":"KH Lee","year":"2017","unstructured":"Lee, K. H. et al. Neutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review. Autoimmun. Rev. 16, 1160\u20131173 (2017).","journal-title":"Autoimmun. Rev."},{"key":"92001_CR8","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1126\/science.aao4227","volume":"361","author":"J Albrengues","year":"2018","unstructured":"Albrengues, J. et al. Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science 361, 20 (2018).","journal-title":"Science"},{"key":"92001_CR9","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1097\/SHK.0000000000000221","volume":"42","author":"G Camicia","year":"2014","unstructured":"Camicia, G., Pozner, R. & de Larranaga, G. Neutrophil extracellular traps in sepsis. Shock 42, 286\u2013294 (2014).","journal-title":"Shock"},{"key":"92001_CR10","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s41584-018-0039-z","volume":"14","author":"F Apel","year":"2018","unstructured":"Apel, F., Zychlinsky, A. & Kenny, E. F. The role of neutrophil extracellular traps in rheumatic diseases. Nat. Rev. Rheumatol. 14, 467\u2013475 (2018).","journal-title":"Nat. Rev. Rheumatol."},{"key":"92001_CR11","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/S0140-6736(17)31930-X","volume":"391","author":"PM Jourdan","year":"2018","unstructured":"Jourdan, P. M., Lamberton, P. H. L., Fenwick, A. & Addiss, D. G. Soil-transmitted helminth infections. Lancet 391, 252\u2013265 (2018).","journal-title":"Lancet"},{"key":"92001_CR12","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1128\/CMR.05040-11","volume":"25","author":"HJ McSorley","year":"2012","unstructured":"McSorley, H. J. & Maizels, R. M. Helminth infections and host immune regulation. Clin. Microbiol. Rev. 25, 585\u2013608 (2012).","journal-title":"Clin. Microbiol. Rev."},{"key":"92001_CR13","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/pim.12299","volume":"38","author":"A Fleury","year":"2016","unstructured":"Fleury, A., Cardenas, G., Adalid-Peralta, L., Fragoso, G. & Sciutto, E. Immunopathology in Taenia solium neurocysticercosis. Parasite Immunol. 38, 147\u2013157 (2016).","journal-title":"Parasite Immunol."},{"key":"92001_CR14","doi-asserted-by":"publisher","first-page":"20","DOI":"10.12688\/f1000research.15596.1","volume":"7","author":"PH Gazzinelli-Guimaraes","year":"2018","unstructured":"Gazzinelli-Guimaraes, P. H. & Nutman, T. B. Helminth parasites and immune regulation. F1000Res 7, 20 (2018).","journal-title":"F1000Res"},{"key":"92001_CR15","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1177\/1759091415592126","volume":"7","author":"A Chauhan","year":"2015","unstructured":"Chauhan, A. et al. Epigenetic modulation of microglial inflammatory gene loci in helminth-induced immune suppression: Implications for immune regulation in neurocysticercosis. ASN Neuro 7, 20 (2015).","journal-title":"ASN Neuro"},{"key":"92001_CR16","doi-asserted-by":"publisher","first-page":"e101023","DOI":"10.1371\/journal.pone.0101023","volume":"9","author":"A Chauhan","year":"2014","unstructured":"Chauhan, A. et al. Helminth induced suppression of macrophage activation is correlated with inhibition of calcium channel activity. PLoS\u00a0One 9, e101023 (2014).","journal-title":"PLoS\u00a0One"},{"key":"92001_CR17","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s12974-014-0210-7","volume":"11","author":"Y Sun","year":"2014","unstructured":"Sun, Y. et al. Inhibition of store-operated calcium entry in microglia by helminth factors: Implications for immune suppression in neurocysticercosis. J. Neuroinflamm. 11, 210 (2014).","journal-title":"J. Neuroinflamm."},{"key":"92001_CR18","doi-asserted-by":"publisher","first-page":"e1006870","DOI":"10.1371\/journal.ppat.1006870","volume":"14","author":"SB Morais","year":"2018","unstructured":"Morais, S. B. et al. Schistosoma mansoni SmKI-1 serine protease inhibitor binds to elastase and impairs neutrophil function and inflammation. PLoS Pathog. 14, e1006870 (2018).","journal-title":"PLoS Pathog."},{"key":"92001_CR19","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.chom.2020.01.011","volume":"27","author":"T Bouchery","year":"2020","unstructured":"Bouchery, T. et al. Hookworms evade host immunity by secreting a deoxyribonuclease to degrade neutrophil extracellular traps. Cell Host Microbe 27, 277-289 e276 (2020).","journal-title":"Cell Host Microbe"},{"key":"92001_CR20","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1017\/S0031182009991971","volume":"137","author":"JI Alvarez","year":"2010","unstructured":"Alvarez, J. I., Mishra, B. B., Gundra, U. M., Mishra, P. K. & Teale, J. M. Mesocestoides corti intracranial infection as a murine model for neurocysticercosis. Parasitology 137, 359\u2013372 (2010).","journal-title":"Parasitology"},{"issue":"12","key":"92001_CR21","doi-asserted-by":"publisher","first-page":"6848","DOI":"10.1096\/fj.201800605","volume":"32","author":"JK Tripathi","year":"2018","unstructured":"Tripathi, J. K. et al. Oxidant sensor cation channel TRPM2 regulates neutrophil extracellular trap formation and protects against pneumoseptic bacterial infection. FASEB J. 32(12), 6848\u20136859 (2018).","journal-title":"FASEB J."},{"key":"92001_CR22","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s13054-019-2407-8","volume":"23","author":"DF Colon","year":"2019","unstructured":"Colon, D. F. et al. Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis. Crit. Care 23, 113 (2019).","journal-title":"Crit. Care"},{"key":"92001_CR23","doi-asserted-by":"publisher","first-page":"L586","DOI":"10.1152\/ajplung.00365.2013","volume":"307","author":"L Luo","year":"2014","unstructured":"Luo, L. et al. Proinflammatory role of neutrophil extracellular traps in abdominal sepsis. Am. J. Physiol. Lung Cell Mol. Physiol. 307, L586-596 (2014).","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"92001_CR24","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1471-2334-9-41","volume":"9","author":"KH Song","year":"2009","unstructured":"Song, K. H. et al. Clinical outcomes of spontaneous bacterial peritonitis due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species: A retrospective matched case-control study. BMC Infect. Dis. 9, 41 (2009).","journal-title":"BMC Infect. Dis."},{"key":"92001_CR25","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1007\/s12072-014-9543-7","volume":"8","author":"MJ Kim","year":"2014","unstructured":"Kim, M. J. et al. Clinical outcomes of spontaneous bacterial peritonitis due to extended-spectrum beta-lactamase-producing Escherichia coli or Klebsiella pneumoniae: A retrospective cohort study. Hepatol. Int. 8, 582\u2013587 (2014).","journal-title":"Hepatol. Int."},{"key":"92001_CR26","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.jaci.2016.07.007","volume":"138","author":"RM Maizels","year":"2016","unstructured":"Maizels, R. M. & McSorley, H. J. Regulation of the host immune system by helminth parasites. J. Allergy Clin. Immunol. 138, 666\u2013675 (2016).","journal-title":"J. Allergy Clin. Immunol."},{"key":"92001_CR27","first-page":"20","volume":"20","author":"B Douglas","year":"2021","unstructured":"Douglas, B. et al. Immune system investigation using parasitic helminths. Annu. Rev. Immunol. 20, 20 (2021).","journal-title":"Annu. Rev. Immunol."},{"key":"92001_CR28","first-page":"20","volume":"20","author":"KE Lothstein","year":"2021","unstructured":"Lothstein, K. E. & Gause, W. C. Mining helminths for novel therapeutics. Trends Mol. Med. 20, 20 (2021).","journal-title":"Trends Mol. Med."},{"key":"92001_CR29","first-page":"145749692098407","volume":"20","author":"TW Clements","year":"2021","unstructured":"Clements, T. W., Tolonen, M., Ball, C. G. & Kirkpatrick, A. W. Secondary peritonitis and intra-abdominal sepsis: An increasingly global disease in search of better systemic therapies. Scand. J. Surg. 20, 1457496920984078 (2021).","journal-title":"Scand. J. Surg."},{"key":"92001_CR30","first-page":"E1","volume":"33","author":"GR Ragetly","year":"2011","unstructured":"Ragetly, G. R., Bennett, R. A. & Ragetly, C. A. Septic peritonitis: Etiology, pathophysiology, and diagnosis. Compend. Contin. Educ. Vet. 33, E1-6 (2011) ((quiz E7)).","journal-title":"Compend. Contin. Educ. Vet."},{"key":"92001_CR31","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1182\/blood-2016-09-741298","volume":"129","author":"B McDonald","year":"2017","unstructured":"McDonald, B. et al. Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice. Blood 129, 1357\u20131367 (2017).","journal-title":"Blood"},{"key":"92001_CR32","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s10020-020-00165-3","volume":"26","author":"J Pravda","year":"2020","unstructured":"Pravda, J. Hydrogen peroxide and disease: Towards a unified system of pathogenesis and therapeutics. Mol. Med. 26, 41 (2020).","journal-title":"Mol. Med."},{"key":"92001_CR33","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1160\/TH08-10-0641","volume":"101","author":"CM Hecquet","year":"2009","unstructured":"Hecquet, C. M. & Malik, A. B. Role of H(2)O(2)-activated TRPM2 calcium channel in oxidant-induced endothelial injury. Thromb. Haemost. 101, 619\u2013625 (2009).","journal-title":"Thromb. Haemost."},{"key":"92001_CR34","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.ceca.2016.02.009","volume":"60","author":"N Ogawa","year":"2016","unstructured":"Ogawa, N., Kurokawa, T. & Mori, Y. Sensing of redox status by TRP channels. Cell Calcium 60, 115\u2013122 (2016).","journal-title":"Cell Calcium"},{"key":"92001_CR35","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ceca.2011.04.006","volume":"50","author":"N Takahashi","year":"2011","unstructured":"Takahashi, N., Kozai, D., Kobayashi, R., Ebert, M. & Mori, Y. Roles of TRPM2 in oxidative stress. Cell Calcium 50, 279\u2013287 (2011).","journal-title":"Cell Calcium"},{"key":"92001_CR36","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3390\/biom9010020","volume":"9","author":"M Ravindran","year":"2019","unstructured":"Ravindran, M., Khan, M. A. & Palaniyar, N. Neutrophil extracellular trap formation: Physiology, pathology, and pharmacology. Biomolecules 9, 20 (2019).","journal-title":"Biomolecules"},{"key":"92001_CR37","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.trsl.2017.09.005","volume":"190","author":"FJ Gonzalez-Gonzalez","year":"2017","unstructured":"Gonzalez-Gonzalez, F. J., Chandel, N. S., Jain, M. & Budinger, G. R. S. Reactive oxygen species as signaling molecules in the development of lung fibrosis. Transl. Res. 190, 61\u201368 (2017).","journal-title":"Transl. Res."},{"key":"92001_CR38","doi-asserted-by":"publisher","first-page":"e1001248","DOI":"10.1371\/journal.ppat.1001248","volume":"7","author":"C Klotz","year":"2011","unstructured":"Klotz, C. et al. A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages. PLoS Pathog. 7, e1001248 (2011).","journal-title":"PLoS Pathog."},{"key":"92001_CR39","doi-asserted-by":"publisher","first-page":"13664","DOI":"10.1074\/jbc.M011157200","volume":"276","author":"W Ma","year":"2001","unstructured":"Ma, W. et al. The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages. J. Biol. Chem. 276, 13664\u201313674 (2001).","journal-title":"J. Biol. Chem."},{"key":"92001_CR40","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.3389\/fimmu.2018.02349","volume":"9","author":"A Zakeri","year":"2018","unstructured":"Zakeri, A., Hansen, E. P., Andersen, S. D., Williams, A. R. & Nejsum, P. Immunomodulation by helminths: Intracellular pathways and extracellular vesicles. Front. Immunol. 9, 2349 (2018).","journal-title":"Front. Immunol."},{"key":"92001_CR41","first-page":"20","volume":"20","author":"A Sharma","year":"2019","unstructured":"Sharma, A. et al. Tamoxifen restores extracellular trap formation in neutrophils from patients with chronic granulomatous disease in a reactive oxygen species-independent manner. J. Allergy Clin. Immunol. 20, 20 (2019).","journal-title":"J. Allergy Clin. Immunol."},{"key":"92001_CR42","doi-asserted-by":"crossref","first-page":"20","DOI":"10.37897\/RJID.2017.1.3","volume":"20","author":"A Sharma","year":"2017","unstructured":"Sharma, A., Simonson, T. J., Jondle, C. N., Mishra, B. B. & Sharma, J. Mincle regulates autophagy to control neutrophil extracellular trap formation. J. Infect. Dis. 20, 20 (2017).","journal-title":"J. Infect. Dis."},{"key":"92001_CR43","doi-asserted-by":"publisher","first-page":"C348","DOI":"10.1152\/ajpcell.00108.2013","volume":"305","author":"A Itakura","year":"2013","unstructured":"Itakura, A. & McCarty, O. J. Pivotal role for the mTOR pathway in the formation of neutrophil extracellular traps via regulation of autophagy. Am. J. Physiol. Cell Physiol. 305, C348-354 (2013).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"92001_CR44","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/ncb2152","volume":"13","author":"J Kim","year":"2011","unstructured":"Kim, J., Kundu, M., Viollet, B. & Guan, K. L. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 13, 132\u2013141 (2011).","journal-title":"Nat. Cell Biol."},{"key":"92001_CR45","doi-asserted-by":"publisher","first-page":"3531","DOI":"10.1128\/MCB.05124-11","volume":"31","author":"PT Mungai","year":"2011","unstructured":"Mungai, P. T. et al. Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels. Mol. Cell Biol. 31, 3531\u20133545 (2011).","journal-title":"Mol. Cell Biol."},{"key":"92001_CR46","doi-asserted-by":"publisher","first-page":"e12964","DOI":"10.1111\/eci.12964","volume":"48 Suppl 2","author":"R Immler","year":"2018","unstructured":"Immler, R., Simon, S. I. & Sperandio, M. Calcium signalling and related ion channels in neutrophil recruitment and function. Eur. J. Clin. Invest. 48 Suppl 2, e12964 (2018).","journal-title":"Eur. J. Clin. Invest."},{"key":"92001_CR47","doi-asserted-by":"publisher","first-page":"2817","DOI":"10.1073\/pnas.1414055112","volume":"112","author":"DN Douda","year":"2015","unstructured":"Douda, D. N., Khan, M. A., Grasemann, H. & Palaniyar, N. SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx. Proc. Natl. Acad. Sci. USA 112, 2817\u20132822 (2015).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"92001_CR48","doi-asserted-by":"publisher","first-page":"3084","DOI":"10.4049\/jimmunol.0803463","volume":"182","author":"KJ Mylonas","year":"2009","unstructured":"Mylonas, K. J., Nair, M. G., Prieto-Lafuente, L., Paape, D. & Allen, J. E. Alternatively activated macrophages elicited by helminth infection can be reprogrammed to enable microbial killing. J. Immunol. 182, 3084\u20133094 (2009).","journal-title":"J. Immunol."},{"key":"92001_CR49","doi-asserted-by":"publisher","first-page":"15703","DOI":"10.1038\/s41598-019-51991-3","volume":"9","author":"SR Long","year":"2019","unstructured":"Long, S. R. et al. Intestinal helminth infection enhances bacteria-induced recruitment of neutrophils to the airspace. Sci. Rep. 9, 15703 (2019).","journal-title":"Sci. Rep."},{"key":"92001_CR50","doi-asserted-by":"crossref","first-page":"e103397","DOI":"10.15252\/embj.2019103397","volume":"39","author":"KW Chen","year":"2020","unstructured":"Chen, K. W., Demarco, B. & Broz, P. Beyond inflammasomes: Emerging function of gasdermins during apoptosis and NETosis. EMBO J. 39, e103397 (2020).","journal-title":"EMBO J."},{"key":"92001_CR51","doi-asserted-by":"publisher","first-page":"6737","DOI":"10.1523\/JNEUROSCI.3575-17.2018","volume":"38","author":"FO Quenum Zangbede","year":"2018","unstructured":"Quenum Zangbede, F. O., Chauhan, A., Sharma, J. & Mishra, B. B. Galectin-3 in M2 macrophages plays a protective role in resolution of neuropathology in brain parasitic infection by regulating neutrophil turnover. J. Neurosci. 38, 6737\u20136750 (2018).","journal-title":"J. Neurosci."},{"key":"92001_CR52","doi-asserted-by":"publisher","first-page":"3088","DOI":"10.4049\/jimmunol.1501790","volume":"196","author":"CN Jondle","year":"2016","unstructured":"Jondle, C. N. et al. Macrophage galactose-type lectin-1 deficiency is associated with increased neutrophilia and hyperinflammation in gram-negative pneumonia. J. Immunol. 196, 3088\u20133096 (2016).","journal-title":"J. Immunol."},{"key":"92001_CR53","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1093\/infdis\/jit820","volume":"209","author":"A Sharma","year":"2014","unstructured":"Sharma, A., Steichen, A. L., Jondle, C. N., Mishra, B. B. & Sharma, J. Protective role of mincle in bacterial pneumonia by regulation of neutrophil mediated phagocytosis and extracellular trap formation. J. Infect. Dis. 209, 1837\u20131846 (2014).","journal-title":"J. Infect. Dis."},{"key":"92001_CR54","first-page":"20","volume":"20","author":"P Sukumaran","year":"2017","unstructured":"Sukumaran, P., Sun, Y., Antonson, N. & Singh, B. B. Dopaminergic neurotoxins induce cell death by attenuating NF-kappaB-mediated regulation of TRPC1 expression and autophagy. FASEB J. 20, 20 (2017).","journal-title":"FASEB J."},{"key":"92001_CR55","doi-asserted-by":"publisher","first-page":"3364","DOI":"10.1523\/JNEUROSCI.3010-16.2017","volume":"37","author":"Y Sun","year":"2017","unstructured":"Sun, Y. et al. Inhibition of L-type Ca(2+) channels by TRPC1-STIM1 complex is essential for the protection of dopaminergic neurons. J. Neurosci. 37, 3364\u20133377 (2017).","journal-title":"J. Neurosci."},{"key":"92001_CR56","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.isci.2018.09.014","volume":"8","author":"A Chauhan","year":"2018","unstructured":"Chauhan, A. et al. M1 macrophage polarization is dependent on TRPC1-mediated calcium entry. iScience 8, 85\u2013102 (2018).","journal-title":"iScience"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92001-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92001-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92001-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T23:17:12Z","timestamp":1699139832000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92001-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,16]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["92001"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-92001-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,16]]},"assertion":[{"value":"16 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"12718"}}