{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:15:47Z","timestamp":1791335747277,"version":"4.3.1"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Regular PCR testing of nasopharyngeal swabs from symptomatic individuals for SARS-CoV-2 virus has become the established method by which health services are managing the COVID-19 pandemic. Businesses such as AstraZeneca have also prioritised voluntary asymptomatic testing to keep workplaces safe and maintain supply of essential medicines to patients. We describe the development of an internal automated SARS-CoV-2 testing programme including the transformative introduction of saliva as an alternative sample type.<\/jats:p>","DOI":"10.1038\/s41598-021-92070-w","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T10:03:04Z","timestamp":1623837784000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A novel automated SARS-CoV-2 saliva PCR test protects a global asymptomatic workforce"],"prefix":"10.1038","volume":"11","author":[{"given":"Nikki","family":"Carter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Clausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Halpin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Blackmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oona","family":"Delpuech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kohlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"March","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"O\u2019Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasthuri","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Sherwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabetha","family":"Sundin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Swift","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azar","family":"Tarakameh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilou","family":"Wijdicks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Wise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Fidock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"92070_CR1","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1056\/NEJMc2016359","volume":"383","author":"AL Wyllie","year":"2020","unstructured":"Wyllie, A. L. et al. Saliva or nasopharyngeal swab specimens for detection of SARS-CoV-2. N. Engl. J. Med. 383, 1283\u20131286 (2020).","journal-title":"N. Engl. J. Med."},{"key":"92070_CR2","doi-asserted-by":"publisher","unstructured":"Romo, M. et al. Patterns of SARS-CoV-2 testing preferences in a national cohort in the United States. Preprint at https:\/\/doi.org\/10.1101\/2020.12.22.20248747v1.full (2020).","DOI":"10.1101\/2020.12.22.20248747v1.full"},{"key":"92070_CR3","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.ijid.2020.05.030","volume":"96","author":"R Zhou","year":"2020","unstructured":"Zhou, R. et al. Viral dynamics in asymptomatic patients with COVID-19. Int. J. Infect. Dis. 96, 288\u2013290 (2020).","journal-title":"Int. J. Infect. Dis."},{"key":"92070_CR4","unstructured":"Cereda, D. et al. The early phase of the COVID-19 outbreak in Lombardy, Italy. Preprint at https:\/\/arxiv.org\/abs\/2003.09320 (2020)."},{"key":"92070_CR5","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S1473-3099(20)30196-1","volume":"20","author":"KK-W To","year":"2020","unstructured":"To, K.K.-W. et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2. Lancet Infect. Dis. 20, 565\u2013574 (2020).","journal-title":"Lancet Infect. Dis."},{"key":"92070_CR6","doi-asserted-by":"publisher","unstructured":"Silva, J. et al. Saliva viral load is a dynamic unifying correlate of COVID-19severity and mortality. Preprint at https:\/\/doi.org\/10.1101\/2021.01.04.21249236v2 (2021).","DOI":"10.1101\/2021.01.04.21249236v2"},{"key":"92070_CR7","doi-asserted-by":"publisher","first-page":"501","DOI":"10.7326\/M20-6569","volume":"174","author":"ML Bastos","year":"2021","unstructured":"Bastos, M. L. et al. The sensitivity and costs of testing for SARS-CoV-2 infection with saliva versus nasopharyngeal swabs. Ann. Intern. Med. 174, 501\u2013510. https:\/\/doi.org\/10.7326\/M20-6569 (2021).","journal-title":"Ann. Intern. Med."},{"key":"92070_CR8","doi-asserted-by":"publisher","first-page":"104567","DOI":"10.1016\/j.jcv.2020.104567","volume":"130","author":"M Landry","year":"2020","unstructured":"Landry, M. et al. Challenges in use of saliva for detection of SARS CoV-2 RNA in symptomatic outpatient. J. Clin. Virol. 130, 104567 (2020).","journal-title":"J. Clin. Virol."},{"key":"92070_CR9","doi-asserted-by":"publisher","unstructured":"Byrne, R. L. et al. Saliva offers a sensitive, specific and non-invasive alternative to upper respiratory swabs for SARS-CoV-2 diagnosis. Preprint at https:\/\/doi.org\/10.1101\/2020.07.09.20149534v1 (2020).","DOI":"10.1101\/2020.07.09.20149534v1"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92070-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92070-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92070-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T09:49:28Z","timestamp":1670060968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92070-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,16]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["92070"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-92070-w","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,16]]},"assertion":[{"value":"5 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Authors\u00a0NC, MC, RH, CB, KC, OD, AK, RM, DO'N, JS, TS, JS, MW and MF are employees of AstraZeneca and have financial interests in the company.\u00a0OM, KP, AT and DW are employed by AstraZeneca.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"12676"}}