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The purpose of this study was to evaluate the efficacy of a low dose (600\u20131800\u00a0mg) of N-Acetylcysteine (NAC) vs placebo on mitigating hangover symptoms. This was a randomized, double-blinded, placebo controlled crossover study involving 49 volunteers who consumed beer to obtain a breath alcohol content (BrAC) of 0.1\u00a0g\/210L. The participants met on two separate occasions at which time they were given either NAC or placebo capsules. Opposing treatments were administered during the second encounter. The morning after the participant\u2019s intoxication and treatment, a Hangover Symptom Scale Questionnaire was administered to determine subjective changes in hangover symptoms. Data was analyzed by self-control, comparing the participant\u2019s hangover symptom severity when using NAC compared to placebo. No significant difference was found in the general distribution of total hangover scores (<jats:italic>P<\/jats:italic>\u2009=\u2009.45) (NAC\u2009=\u200910; Placebo\u2009=\u200913). There was also no significant difference found in the general distribution of specific hangover symptoms. However, a significant difference was found in the general distribution of total hangover difference scores based on gender (<jats:italic>P<\/jats:italic>\u2009=\u2009.04) (Female \u2212\u00a03.5; Male 2), specifically for nausea (<jats:italic>P<\/jats:italic>\u2009=\u2009.05) and weakness (<jats:italic>P<\/jats:italic>\u2009=\u2009.03). Although no difference was found in the general hangover scale scores, the study was suggestive of gender specific susceptibility with female participants having improved hangover symptoms after NAC use.<\/jats:p>","DOI":"10.1038\/s41598-021-92676-0","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T10:02:47Z","timestamp":1624874567000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The use of N-acetylcysteine in the prevention of hangover: a randomized trial"],"prefix":"10.1038","volume":"11","author":[{"given":"Veronica","family":"Coppersmith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Hudgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Stoltzfus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Stankewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"92676_CR1","doi-asserted-by":"publisher","first-page":"148","DOI":"10.2174\/1874473710666170216125822","volume":"9","author":"MS van Lantman","year":"2016","unstructured":"van Lantman, M. 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However, the author was not doing this consulting before or during this study or when the manuscript was written. She started doing this consulting years after this study was completed. No other authors have any conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"13397"}}