{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:06:12Z","timestamp":1791986772129,"version":"4.4.0"},"reference-count":109,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dengue virus type 2 (DENV-2) contributes substantially to the dengue burden and dengue-related mortality in the tropics and sub-tropics. DENV-2 includes six genotypes, among which cosmopolitan genotype is the most widespread. The present study investigated the evolution, intra-genotype heterogeneity and dispersal of cosmopolitan genotype to understand unique genetic characteristics that have shaped the molecular epidemiology and distribution of cosmopolitan lineages. The spatial analysis demonstrated a wide geo-distribution of cosmopolitan genotype through an extensive inter-continental network, anchored in Southeast Asia and Indian sub-continent. Intra-genotype analyses using 3367 envelope gene sequences revealed six distinct lineages within the cosmopolitan genotype, namely the Indian sub-continent lineage and five other lineages. Indian sub-continent lineage was the most diverged among six lineages and has almost reached the nucleotide divergence threshold of 6% within <jats:italic>E<\/jats:italic> gene to qualify as a separate genotype. Genome wide amino acid signatures and selection pressure analyses further suggested differences in evolutionary characteristics between the Indian sub-continent lineage and other lineages. The present study narrates a comprehensive genomic analysis of cosmopolitan genotype and presents notable genetic characteristics that occurred during its evolution and global expansion. Whether those characteristics conferred a fitness advantage to cosmopolitan genotype in different geographies warrant further investigations.<\/jats:p>","DOI":"10.1038\/s41598-021-92783-y","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T10:07:24Z","timestamp":1624961244000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Evolution, heterogeneity and global dispersal of cosmopolitan genotype of Dengue virus type 2"],"prefix":"10.1038","volume":"11","author":[{"given":"Surya Pavan","family":"Yenamandra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Koo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanna","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Shi Jeri","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen Yuan","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee Ching","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hapuarachchige Chanditha","family":"Hapuarachchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"92783_CR1","volume-title":"Global Strategy for Dengue Prevention and Control 2012\u20132020","author":"WHO","year":"2012","unstructured":"WHO. Global Strategy for Dengue Prevention and Control 2012\u20132020. (World Health Organization, Geneva, 2012)."},{"issue":"6","key":"92783_CR2","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/S1473-3099(16)00026-8","volume":"16","author":"JD Stanaway","year":"2016","unstructured":"Stanaway, J. D. et al. The global burden of dengue: An analysis from the Global Burden of Disease Study 2013. Lancet Infect. Dis. 16(6), 712\u2013723 (2016).","journal-title":"Lancet Infect. Dis."},{"issue":"3","key":"92783_CR3","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.tim.2013.12.011","volume":"22","author":"JP Messina","year":"2014","unstructured":"Messina, J. P. et al. Global spread of dengue virus types: Mapping the 70 year history. Trends Microbiol. 22(3), 138\u2013146 (2014).","journal-title":"Trends Microbiol."},{"issue":"5","key":"92783_CR4","doi-asserted-by":"publisher","first-page":"357","DOI":"10.7883\/yoken.JJID.2014.313","volume":"68","author":"DH Putri","year":"2015","unstructured":"Putri, D. H. et al. Immunogenicity of a candidate DNA vaccine based on the prM\/E genes of a dengue type 2 virus cosmopolitan genotype strain. Jpn. J. Infect. Dis. 68(5), 357\u2013363 (2015).","journal-title":"Jpn. J. Infect. Dis."},{"issue":"9","key":"92783_CR5","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.3390\/v3091562","volume":"3","author":"R Chen","year":"2011","unstructured":"Chen, R. & Vasilakis, N. Dengue\u2013quo tu et quo vadis?. Viruses 3(9), 1562\u20131608 (2011).","journal-title":"Viruses"},{"issue":"2","key":"92783_CR6","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/0042-6822(90)90102-W","volume":"174","author":"R Rico-Hesse","year":"1990","unstructured":"Rico-Hesse, R. Molecular evolution and distribution of dengue viruses type 1 and 2 in nature. Virology 174(2), 479\u2013493 (1990).","journal-title":"Virology"},{"issue":"1","key":"92783_CR7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S1567-1348(03)00004-2","volume":"3","author":"EC Holmes","year":"2003","unstructured":"Holmes, E. C. & Twiddy, S. S. The origin, emergence and evolutionary genetics of dengue virus. Infect. Genet. Evol. 3(1), 19\u201328 (2003).","journal-title":"Infect. Genet. Evol."},{"issue":"2","key":"92783_CR8","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1128\/JVI.79.2.853-859.2005","volume":"79","author":"R Cologna","year":"2005","unstructured":"Cologna, R., Armstrong, P. M. & Rico-Hesse, R. Selection for virulent dengue viruses occurs in humans and mosquitoes. J. Virol. 79(2), 853\u2013859 (2005).","journal-title":"J. Virol."},{"issue":"7","key":"92783_CR9","doi-asserted-by":"publisher","first-page":"3929","DOI":"10.1128\/JVI.77.7.3929-3938.2003","volume":"77","author":"R Cologna","year":"2003","unstructured":"Cologna, R. & Rico-Hesse, R. American genotype structures decrease dengue virus output from human monocytes and dendritic cells. J. Virol. 77(7), 3929\u20133938 (2003).","journal-title":"J. Virol."},{"key":"92783_CR10","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3389\/fcimb.2017.00317","volume":"7","author":"C Guo","year":"2017","unstructured":"Guo, C. et al. Global epidemiology of dengue outbreaks in 1990\u20132015: A systematic review and meta-analysis. Front. Cell Infect Microbiol. 7, 317 (2017).","journal-title":"Front. Cell Infect Microbiol."},{"issue":"1","key":"92783_CR11","doi-asserted-by":"publisher","first-page":"9395","DOI":"10.1038\/s41598-019-45816-6","volume":"9","author":"R Aguas","year":"2019","unstructured":"Aguas, R. et al. Cross-serotype interactions and disease outcome prediction of dengue infections in Vietnam. Sci. Rep. 9(1), 9395 (2019).","journal-title":"Sci. Rep."},{"issue":"3","key":"92783_CR12","doi-asserted-by":"publisher","first-page":"e617","DOI":"10.1371\/journal.pntd.0000617","volume":"4","author":"JR Fried","year":"2010","unstructured":"Fried, J. R. et al. Serotype-specific differences in the risk of dengue hemorrhagic fever: An analysis of data collected in Bangkok, Thailand from 1994 to 2006. PLoS Negl. Trop. Dis. 4(3), e617 (2010).","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"1","key":"92783_CR13","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1006\/viro.2002.1447","volume":"298","author":"SS Twiddy","year":"2002","unstructured":"Twiddy, S. S. et al. Phylogenetic relationships and differential selection pressures among genotypes of dengue-2 virus. Virology 298(1), 63\u201372 (2002).","journal-title":"Virology"},{"issue":"4","key":"92783_CR14","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.meegid.2009.02.003","volume":"9","author":"SC Weaver","year":"2009","unstructured":"Weaver, S. C. & Vasilakis, N. Molecular evolution of dengue viruses: Contributions of phylogenetics to understanding the history and epidemiology of the preeminent arboviral disease. Infect. Genet. Evol. 9(4), 523\u2013540 (2009).","journal-title":"Infect. Genet. Evol."},{"issue":"4","key":"92783_CR15","doi-asserted-by":"publisher","first-page":"784","DOI":"10.3201\/eid2504.180958","volume":"25","author":"SC Hill","year":"2019","unstructured":"Hill, S. C. et al. Early genomic detection of cosmopolitan genotype of dengue virus serotype 2, Angola, 2018. Emerg. Infect. Dis. 25(4), 784\u2013787 (2019).","journal-title":"Emerg. Infect. Dis."},{"issue":"3","key":"92783_CR16","doi-asserted-by":"publisher","first-page":"e56391","DOI":"10.1371\/journal.pone.0056391","volume":"8","author":"MA Khan","year":"2013","unstructured":"Khan, M. A. et al. Emergence and diversification of dengue 2 cosmopolitan genotype in Pakistan, 2011. PLoS ONE 8(3), e56391 (2013).","journal-title":"PLoS ONE"},{"issue":"26","key":"92783_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2807\/1560-7917.ES.2017.22.26.30563","volume":"22","author":"Y Lustig","year":"2017","unstructured":"Lustig, Y. et al. An outbreak of dengue virus (DENV) type 2 Cosmopolitan genotype in Israeli travellers returning from the Seychelles, April 2017. Euro. Surveill. 22(26), 1\u201310 (2017).","journal-title":"Euro. Surveill."},{"issue":"11","key":"92783_CR18","doi-asserted-by":"publisher","first-page":"e0207220","DOI":"10.1371\/journal.pone.0207220","volume":"13","author":"J Phadungsombat","year":"2018","unstructured":"Phadungsombat, J. et al. Emergence of genotype Cosmopolitan of dengue virus type 2 and genotype III of dengue virus type 3 in Thailand. PLoS ONE 13(11), e0207220 (2018).","journal-title":"PLoS ONE"},{"issue":"2","key":"92783_CR19","doi-asserted-by":"publisher","first-page":"26","DOI":"10.5365\/wpsar.2016.7.1.002","volume":"7","author":"LT Soh","year":"2016","unstructured":"Soh, L. T. et al. External quality assessment of dengue and chikungunya diagnostics in the Asia Pacific region, 2015. Western Pac. Surveill. Response J. 7(2), 26\u201334 (2016).","journal-title":"Western Pac. Surveill. Response J."},{"issue":"5","key":"92783_CR20","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1111\/j.1365-3156.2011.02734.x","volume":"16","author":"S Banu","year":"2011","unstructured":"Banu, S. et al. Dengue transmission in the Asia-Pacific region: Impact of climate change and socio-environmental factors. Trop. Med. Int. Health 16(5), 598\u2013607 (2011).","journal-title":"Trop. Med. Int. Health"},{"issue":"5","key":"92783_CR21","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/rmv.545","volume":"17","author":"G Kuno","year":"2007","unstructured":"Kuno, G. Research on dengue and dengue-like illness in East Asia and the Western Pacific during the First Half of the 20th century. Rev. Med. Virol. 17(5), 327\u2013341 (2007).","journal-title":"Rev. Med. Virol."},{"issue":"2","key":"92783_CR22","first-page":"130","volume":"35","author":"NC de Francisco","year":"1983","unstructured":"de Francisco, N. C. Dengue hemorrhagic fever: Southeast Asia and the Western Pacific (review article) (I). Rev. Cubana Med. Trop. 35(2), 130\u2013135 (1983).","journal-title":"Rev. Cubana Med. Trop."},{"key":"92783_CR23","doi-asserted-by":"publisher","first-page":"103947","DOI":"10.1016\/j.meegid.2019.103947","volume":"75","author":"CI Ayolabi","year":"2019","unstructured":"Ayolabi, C. I. et al. Detection of Dengue viruses among febrile patients in Lagos, Nigeria and phylogenetics of circulating Dengue serotypes in Africa. Infect Genet Evol 75, 103947 (2019).","journal-title":"Infect Genet Evol"},{"issue":"6","key":"92783_CR24","doi-asserted-by":"publisher","first-page":"426","DOI":"10.7883\/yoken.JJID.2018.554","volume":"72","author":"SP Yamamoto","year":"2019","unstructured":"Yamamoto, S. P. et al. Dengue virus in traveler returning to Japan from the Democratic Republic of the Congo, 2015. Jpn. J. Infect. Dis. 72(6), 426\u2013428 (2019).","journal-title":"Jpn. J. Infect. Dis."},{"issue":"9","key":"92783_CR25","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.3201\/eid2509.190814","volume":"25","author":"K Okada","year":"2019","unstructured":"Okada, K. et al. Dengue virus type 1 infection in traveler returning from Tanzania to Japan, 2019. Emerg. Infect. Dis. 25(9), 1782\u20131784 (2019).","journal-title":"Emerg. Infect. Dis."},{"issue":"5","key":"92783_CR26","doi-asserted-by":"publisher","first-page":"340","DOI":"10.7883\/yoken.JJID.2018.537","volume":"72","author":"T Matsui","year":"2019","unstructured":"Matsui, T. et al. Dengue virus type 2 infection in a traveler returning from Saudi Arabia to Japan. Jpn. J. Infect. Dis. 72(5), 340\u2013342 (2019).","journal-title":"Jpn. J. Infect. Dis."},{"key":"92783_CR27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3201\/eid2311.171293","volume":"23","author":"M Tsuboi","year":"2017","unstructured":"Tsuboi, M. et al. Dengue virus type 2 in travelers returning to Japan from Sri Lanka, 2017. Emerg. Infect. Dis. 23, 11 (2017).","journal-title":"Emerg. Infect. Dis."},{"key":"92783_CR28","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3201\/eid2310.171132","volume":"23","author":"T Suzuki","year":"2017","unstructured":"Suzuki, T. et al. Dengue virus exported from Cote d\u2019Ivoire to Japan, June 2017. Emerg. Infect. Dis. 23, 10 (2017).","journal-title":"Emerg. Infect. Dis."},{"issue":"1","key":"92783_CR29","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.phrp.2015.12.001","volume":"7","author":"YE Jeong","year":"2016","unstructured":"Jeong, Y. E. et al. Comparison of the epidemiological aspects of imported dengue cases between Korea and Japan, 2006\u20132010. Osong Public Health Res. Perspect. 7(1), 71\u201374 (2016).","journal-title":"Osong Public Health Res. Perspect."},{"issue":"1","key":"92783_CR30","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1080\/22221751.2020.1775497","volume":"9","author":"T Tsheten","year":"2020","unstructured":"Tsheten, T. et al. Spatial and temporal patterns of dengue incidence in Bhutan: A Bayesian analysis. Emerg. Microbes Infect. 9(1), 1360\u20131371 (2020).","journal-title":"Emerg. Microbes Infect."},{"issue":"4","key":"92783_CR31","doi-asserted-by":"publisher","first-page":"e0008165","DOI":"10.1371\/journal.pntd.0008165","volume":"14","author":"S Zangmo","year":"2020","unstructured":"Zangmo, S. et al. Molecular epidemiology of dengue fever outbreaks in Bhutan, 2016\u20132017. PLoS Negl. Trop. Dis. 14(4), e0008165 (2020).","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"8","key":"92783_CR32","doi-asserted-by":"publisher","first-page":"e0004010","DOI":"10.1371\/journal.pntd.0004010","volume":"9","author":"S Zangmo","year":"2015","unstructured":"Zangmo, S. et al. Epidemiological and molecular characterization of dengue virus circulating in Bhutan, 2013\u20132014. PLoS Negl. Trop. Dis. 9(8), e0004010 (2015).","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"10","key":"92783_CR33","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.3201\/eid1510.090123","volume":"15","author":"T Dorji","year":"2009","unstructured":"Dorji, T. et al. Diversity and origin of dengue virus serotypes 1, 2, and 3, Bhutan. Emerg. Infect. Dis. 15(10), 1630\u20131632 (2009).","journal-title":"Emerg. Infect. Dis."},{"key":"92783_CR34","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1186\/s12879-016-1606-z","volume":"16","author":"HC Hapuarachchi","year":"2016","unstructured":"Hapuarachchi, H. C. et al. Epidemic resurgence of dengue fever in Singapore in 2013\u20132014: A virological and entomological perspective. BMC Infect. Dis. 16, 300 (2016).","journal-title":"BMC Infect. Dis."},{"issue":"1","key":"92783_CR35","doi-asserted-by":"publisher","first-page":"204","DOI":"10.4269\/ajtmh.17-0819","volume":"99","author":"J Rajarethinam","year":"2018","unstructured":"Rajarethinam, J. et al. Dengue in Singapore from 2004 to 2016: Cyclical epidemic patterns dominated by serotypes 1 and 2. Am. J. Trop. Med. Hyg. 99(1), 204\u2013210 (2018).","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"14","key":"92783_CR36","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.1093\/bioinformatics\/bty121","volume":"34","author":"T Nakamura","year":"2018","unstructured":"Nakamura, T. et al. Parallelization of MAFFT for large-scale multiple sequence alignments. Bioinformatics 34(14), 2490\u20132492 (2018).","journal-title":"Bioinformatics"},{"key":"92783_CR37","doi-asserted-by":"publisher","first-page":"22592","DOI":"10.1038\/srep22592","volume":"6","author":"HC Hapuarachchi","year":"2016","unstructured":"Hapuarachchi, H. C. et al. Intra-epidemic evolutionary dynamics of a Dengue virus type 1 population reveal mutant spectra that correlate with disease transmission. Sci. Rep. 6, 22592 (2016).","journal-title":"Sci. Rep."},{"issue":"6","key":"92783_CR38","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1089\/vbz.2010.0028","volume":"11","author":"CH Tan","year":"2011","unstructured":"Tan, C. H. et al. Evaluation of the Dengue NS1 Ag Strip(R) for detection of dengue virus antigen in Aedes aegypti (Diptera: Culicidae). Vector Borne Zoonotic Dis. 11(6), 789\u2013792 (2011).","journal-title":"Vector Borne Zoonotic Dis."},{"issue":"7","key":"92783_CR39","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1093\/molbev\/msw054","volume":"33","author":"S Kumar","year":"2016","unstructured":"Kumar, S., Stecher, G. & Tamura, K. MEGA7: Molecular evolutionary genetics analysis version 7.0 for bigger datasets. Mol. Biol. Evol. 33(7), 1870\u20131874 (2016).","journal-title":"Mol. Biol. Evol."},{"issue":"4","key":"92783_CR40","doi-asserted-by":"publisher","first-page":"e1003537","DOI":"10.1371\/journal.pcbi.1003537","volume":"10","author":"R Bouckaert","year":"2014","unstructured":"Bouckaert, R. et al. BEAST 2: A software platform for Bayesian evolutionary analysis. PLoS Comput. Biol. 10(4), e1003537 (2014).","journal-title":"PLoS Comput. Biol."},{"issue":"8","key":"92783_CR41","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1093\/molbev\/mss075","volume":"29","author":"AJ Drummond","year":"2012","unstructured":"Drummond, A. J. et al. Bayesian phylogenetics with BEAUti and the BEAST 1.7. Mol. Biol. Evol. 29(8), 1969\u20131973 (2012).","journal-title":"Mol. Biol. Evol."},{"issue":"8","key":"92783_CR42","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/nmeth.2109","volume":"9","author":"D Darriba","year":"2012","unstructured":"Darriba, D. et al. jModelTest 2: More models, new heuristics and parallel computing. Nat. Methods 9(8), 772 (2012).","journal-title":"Nat. Methods"},{"issue":"9","key":"92783_CR43","doi-asserted-by":"publisher","first-page":"e1000520","DOI":"10.1371\/journal.pcbi.1000520","volume":"5","author":"P Lemey","year":"2009","unstructured":"Lemey, P. et al. Bayesian phylogeography finds its roots. PLoS Comput. Biol. 5(9), e1000520 (2009).","journal-title":"PLoS Comput. Biol."},{"issue":"5","key":"92783_CR44","doi-asserted-by":"publisher","first-page":"e88","DOI":"10.1371\/journal.pbio.0040088","volume":"4","author":"AJ Drummond","year":"2006","unstructured":"Drummond, A. J. et al. Relaxed phylogenetics and dating with confidence. PLoS Biol. 4(5), e88 (2006).","journal-title":"PLoS Biol."},{"issue":"20","key":"92783_CR45","doi-asserted-by":"publisher","first-page":"2910","DOI":"10.1093\/bioinformatics\/btr481","volume":"27","author":"F Bielejec","year":"2011","unstructured":"Bielejec, F. et al. SPREAD: Spatial phylogenetic reconstruction of evolutionary dynamics. Bioinformatics 27(20), 2910\u20132912 (2011).","journal-title":"Bioinformatics"},{"issue":"1614","key":"92783_CR46","doi-asserted-by":"publisher","first-page":"20120196","DOI":"10.1098\/rstb.2012.0196","volume":"368","author":"NR Faria","year":"2013","unstructured":"Faria, N. R. et al. Simultaneously reconstructing viral cross-species transmission history and identifying the underlying constraints. Philos. Trans. R. Soc. Lond. B 368(1614), 20120196 (2013).","journal-title":"Philos. Trans. R. Soc. Lond. B"},{"issue":"9","key":"92783_CR47","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1093\/bioinformatics\/btp033","volume":"25","author":"AM Waterhouse","year":"2009","unstructured":"Waterhouse, A. M. et al. Jalview Version 2: A multiple sequence alignment editor and analysis workbench. Bioinformatics 25(9), 1189\u20131191 (2009).","journal-title":"Bioinformatics"},{"key":"92783_CR48","first-page":"95","volume":"41","author":"TA Hall","year":"1999","unstructured":"Hall, T. A. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95\/98\/NT. Nucl. Acids. Symp. Ser 41, 95\u201398 (1999).","journal-title":"Nucl. Acids. Symp. Ser"},{"issue":"10","key":"92783_CR49","doi-asserted-by":"publisher","first-page":"5269","DOI":"10.1073\/pnas.76.10.5269","volume":"76","author":"M Nei","year":"1979","unstructured":"Nei, M. & Li, W. H. Mathematical model for studying genetic variation in terms of restriction endonucleases. Proc. Natl. Acad. Sci. USA 76(10), 5269\u20135273 (1979).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11","key":"92783_CR50","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1093\/bioinformatics\/btp163","volume":"25","author":"PJ Cock","year":"2009","unstructured":"Cock, P. J. et al. Biopython: freely available Python tools for computational molecular biology and bioinformatics. Bioinformatics 25(11), 1422\u20131423 (2009).","journal-title":"Bioinformatics"},{"issue":"12","key":"92783_CR51","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1093\/bioinformatics\/btq228","volume":"26","author":"J Sukumaran","year":"2010","unstructured":"Sukumaran, J. & Holder, M. T. DendroPy: A Python library for phylogenetic computing. Bioinformatics 26(12), 1569\u20131571 (2010).","journal-title":"Bioinformatics"},{"issue":"19","key":"92783_CR52","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1093\/bioinformatics\/btq429","volume":"26","author":"W Delport","year":"2010","unstructured":"Delport, W. et al. Datamonkey 2010: a suite of phylogenetic analysis tools for evolutionary biology. Bioinformatics 26(19), 2455\u20137 (2010).","journal-title":"Bioinformatics"},{"key":"92783_CR53","unstructured":"R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna (2018). https:\/\/www.R-project.org\/."},{"issue":"1","key":"92783_CR54","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.tmaid.2014.11.001","volume":"13","author":"S Dinu","year":"2015","unstructured":"Dinu, S. et al. Molecular epidemiology of dengue fever cases imported into Romania between 2008 and 2013. Travel Med. Infect. Dis. 13(1), 69\u201373 (2015).","journal-title":"Travel Med. Infect. Dis."},{"issue":"6","key":"92783_CR55","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1089\/vbz.2015.1911","volume":"16","author":"SA El-Kafrawy","year":"2016","unstructured":"El-Kafrawy, S. A. et al. Multiple introductions of dengue 2 virus strains into Saudi Arabia from 1992 to 2014. Vector Borne Zoonotic Dis. 16(6), 391\u2013399 (2016).","journal-title":"Vector Borne Zoonotic Dis."},{"issue":"1","key":"92783_CR56","doi-asserted-by":"publisher","first-page":"e0003442","DOI":"10.1371\/journal.pntd.0003442","volume":"9","author":"T Ernst","year":"2015","unstructured":"Ernst, T. et al. Emergence of a new lineage of dengue virus type 2 identified in travelers entering Western Australia from Indonesia, 2010\u20132012. PLoS Negl. Trop. Dis. 9(1), e0003442 (2015).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"92783_CR57","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1128\/genomeA.00076-18","volume":"6","author":"K Gathii","year":"2018","unstructured":"Gathii, K. et al. Complete coding sequences of dengue virus type 2 strains from febrile patients seen in Malindi District Hospital, Kenya, during the 2017 dengue fever outbreak. Genome Announc. 6, 15 (2018).","journal-title":"Genome Announc."},{"key":"92783_CR58","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.4103\/0971-5916.176564","volume":"142","author":"BP Gupta","year":"2015","unstructured":"Gupta, B. P. et al. Re-emergence of dengue virus serotype 2 strains in the 2013 outbreak in Nepal. Indian J. Med. Res. 142, S1-6 (2015).","journal-title":"Indian J. Med. Res."},{"issue":"8","key":"92783_CR59","doi-asserted-by":"publisher","first-page":"e0221179","DOI":"10.1371\/journal.pone.0221179","volume":"14","author":"R Hamel","year":"2019","unstructured":"Hamel, R. et al. Phylogenetic analysis revealed the co-circulation of four dengue virus serotypes in Southern Thailand. PLoS ONE 14(8), e0221179 (2019).","journal-title":"PLoS ONE"},{"issue":"1","key":"92783_CR60","doi-asserted-by":"publisher","first-page":"58","DOI":"10.7883\/yoken.JJID.2018.267","volume":"72","author":"Z Hamid","year":"2019","unstructured":"Hamid, Z. et al. Molecular investigation of dengue virus serotype 2 circulation in Kassala State, Sudan. Jpn. J. Infect. Dis. 72(1), 58\u201361 (2019).","journal-title":"Jpn. J. Infect. Dis."},{"issue":"1","key":"92783_CR61","doi-asserted-by":"publisher","first-page":"026","DOI":"10.1093\/ve\/veaa026","volume":"6","author":"SK Langat","year":"2020","unstructured":"Langat, S. K. et al. Origin and evolution of dengue virus type 2 causing outbreaks in Kenya: Evidence of circulation of two cosmopolitan genotype lineages. Virus Evol. 6(1), 026 (2020).","journal-title":"Virus Evol."},{"issue":"1","key":"92783_CR62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jme\/tjv168","volume":"53","author":"M Grunnill","year":"2016","unstructured":"Grunnill, M. & Boots, M. How important is vertical transmission of dengue viruses by mosquitoes (Diptera: Culicidae)?. J. Med. Entomol. 53(1), 1\u201319 (2016).","journal-title":"J. Med. Entomol."},{"issue":"4 Suppl","key":"92783_CR63","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2149\/tmh.2011-S05","volume":"39","author":"DJ Gubler","year":"2011","unstructured":"Gubler, D. J. Dengue, urbanization and globalization: the unholy trinity of the 21(st) century. Trop. Med. Health 39(4 Suppl), 3\u201311 (2011).","journal-title":"Trop. Med. Health"},{"key":"92783_CR64","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.meegid.2014.01.001","volume":"22","author":"AM Walimbe","year":"2014","unstructured":"Walimbe, A. M. et al. Global phylogeography of dengue type 1 and 2 viruses reveals the role of India. Infect. Genet. Evol. 22, 30\u201339 (2014).","journal-title":"Infect. Genet. Evol."},{"issue":"1","key":"92783_CR65","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1534\/genetics.118.301319","volume":"211","author":"W Stephan","year":"2019","unstructured":"Stephan, W. Selective sweeps. Genetics 211(1), 5\u201313 (2019).","journal-title":"Genetics"},{"issue":"3","key":"92783_CR66","doi-asserted-by":"publisher","first-page":"e0004511","DOI":"10.1371\/journal.pntd.0004511","volume":"10","author":"N Afreen","year":"2016","unstructured":"Afreen, N. et al. Evolutionary analysis of dengue serotype 2 viruses using phylogenetic and bayesian methods from New Delhi, India. PLoS Negl. Trop. Dis. 10(3), e0004511 (2016).","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"3","key":"92783_CR67","doi-asserted-by":"publisher","first-page":"231","DOI":"10.4103\/0972-9062.289402","volume":"56","author":"S Ujwal","year":"2019","unstructured":"Ujwal, S. et al. Circulation of Asian-I and Cosmopolitan genotypes of Dengue-2 virus in northeast India, 2016\u20132017. J. Vector Borne Dis. 56(3), 231\u2013236 (2019).","journal-title":"J. Vector Borne Dis."},{"key":"92783_CR68","doi-asserted-by":"publisher","first-page":"45505","DOI":"10.1038\/srep45505","volume":"7","author":"K Wei","year":"2017","unstructured":"Wei, K. & Li, Y. Global evolutionary history and spatio-temporal dynamics of dengue virus type 2. Sci. Rep. 7, 45505 (2017).","journal-title":"Sci. Rep."},{"issue":"2","key":"92783_CR69","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1006\/viro.1995.1038","volume":"206","author":"MS Marin","year":"1995","unstructured":"Marin, M. S. et al. Phylogeny of TYU, SRE, and CFA virus: Different evolutionary rates in the genus Flavivirus. Virology 206(2), 1133\u20131139 (1995).","journal-title":"Virology"},{"issue":"2","key":"92783_CR70","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1073\/pnas.93.2.548","volume":"93","author":"PM Zanotto","year":"1996","unstructured":"Zanotto, P. M. et al. Population dynamics of flaviviruses revealed by molecular phylogenies. Proc. Natl. Acad. Sci. USA 93(2), 548\u2013553 (1996).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"92783_CR71","doi-asserted-by":"publisher","first-page":"e1006111","DOI":"10.1371\/journal.pgen.1006111","volume":"12","author":"S Lequime","year":"2016","unstructured":"Lequime, S. et al. Genetic drift, purifying selection and vector genotype shape dengue virus intra-host genetic diversity in mosquitoes. PLoS Genet 12(6), e1006111 (2016).","journal-title":"PLoS Genet"},{"issue":"1","key":"92783_CR72","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/genetics\/155.1.431","volume":"155","author":"Z Yang","year":"2000","unstructured":"Yang, Z. et al. Codon-substitution models for heterogeneous selection pressure at amino acid sites. Genetics 155(1), 431\u2013449 (2000).","journal-title":"Genetics"},{"issue":"5","key":"92783_CR73","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1093\/molbev\/msi105","volume":"22","author":"SL Kosakovsky Pond","year":"2005","unstructured":"Kosakovsky Pond, S. L. & Frost, S. D. Not so different after all: A comparison of methods for detecting amino acid sites under selection. Mol. Biol. Evol. 22(5), 1208\u20131222 (2005).","journal-title":"Mol. Biol. Evol."},{"issue":"5","key":"92783_CR74","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1093\/molbev\/mst030","volume":"30","author":"B Murrell","year":"2013","unstructured":"Murrell, B. et al. FUBAR: A fast, unconstrained bayesian approximation for inferring selection. Mol. Biol. Evol. 30(5), 1196\u20131205 (2013).","journal-title":"Mol. Biol. Evol."},{"issue":"7","key":"92783_CR75","doi-asserted-by":"publisher","first-page":"e1002764","DOI":"10.1371\/journal.pgen.1002764","volume":"8","author":"B Murrell","year":"2012","unstructured":"Murrell, B. et al. Detecting individual sites subject to episodic diversifying selection. PLoS Genet. 8(7), e1002764 (2012).","journal-title":"PLoS Genet."},{"issue":"11","key":"92783_CR76","doi-asserted-by":"publisher","first-page":"e27459","DOI":"10.1371\/journal.pone.0027459","volume":"6","author":"G Anez","year":"2011","unstructured":"Anez, G., Morales-Betoulle, M. E. & Rios, M. Circulation of different lineages of dengue virus type 2 in Central America, their evolutionary time-scale and selection pressure analysis. PLoS ONE 6(11), e27459 (2011).","journal-title":"PLoS ONE"},{"issue":"16","key":"92783_CR77","doi-asserted-by":"publisher","first-page":"8546","DOI":"10.1128\/JVI.00736-12","volume":"86","author":"P Parameswaran","year":"2012","unstructured":"Parameswaran, P. et al. Genome-wide patterns of intrahuman dengue virus diversity reveal associations with viral phylogenetic clade and interhost diversity. J. Virol. 86(16), 8546\u20138558 (2012).","journal-title":"J. Virol."},{"issue":"3","key":"92783_CR78","first-page":"269","volume":"18","author":"A Sumarmo","year":"1987","unstructured":"Sumarmo, A. Dengue haemorrhagic fever in Indonesia. Southeast Asian J. Trop. Med. Public Health 18(3), 269\u2013274 (1987).","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"issue":"6","key":"92783_CR79","doi-asserted-by":"publisher","first-page":"733","DOI":"10.3855\/jidc.3959","volume":"8","author":"R Nusa","year":"2014","unstructured":"Nusa, R. et al. Molecular surveillance of Dengue in Sukabumi, West Java province, Indonesia. J. Infect. Dev. 8(6), 733\u2013741 (2014).","journal-title":"J. Infect. Dev."},{"issue":"3","key":"92783_CR80","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1080\/20477724.2016.1184864","volume":"110","author":"S Haryanto","year":"2016","unstructured":"Haryanto, S. et al. The molecular and clinical features of dengue during outbreak in Jambi, Indonesia in 2015. Pathog. Glob. Health 110(3), 119\u2013129 (2016).","journal-title":"Pathog. Glob. Health"},{"key":"92783_CR81","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.meegid.2015.11.002","volume":"37","author":"T Kotaki","year":"2016","unstructured":"Kotaki, T. et al. Divergence of the dengue virus type 2 Cosmopolitan genotype associated with two predominant serotype shifts between 1 and 2 in Surabaya, Indonesia, 2008\u20132014. Infect. Genet. Evol. 37, 88\u201393 (2016).","journal-title":"Infect. Genet. Evol."},{"issue":"5","key":"92783_CR82","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.jiph.2017.09.019","volume":"11","author":"ES Kusmintarsih","year":"2018","unstructured":"Kusmintarsih, E. S. et al. Molecular characterization of dengue viruses isolated from patients in Central Java, Indonesia. J. Infect. Public Health 11(5), 617\u2013625 (2018).","journal-title":"J. Infect. Public Health"},{"issue":"5","key":"92783_CR83","doi-asserted-by":"publisher","first-page":"e0005483","DOI":"10.1371\/journal.pntd.0005483","volume":"11","author":"D Megawati","year":"2017","unstructured":"Megawati, D. et al. Dengue in Bali: Clinical characteristics and genetic diversity of circulating dengue viruses. PLoS Negl. Trop. Dis. 11(5), e0005483 (2017).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"92783_CR84","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.meegid.2015.03.006","volume":"32","author":"RT Sasmono","year":"2015","unstructured":"Sasmono, R. T. et al. Genomic analysis and growth characteristic of dengue viruses from Makassar, Indonesia. Infect. Genet. Evol. 32, 165\u2013177 (2015).","journal-title":"Infect. Genet. Evol."},{"issue":"1","key":"92783_CR85","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s12985-019-1202-0","volume":"16","author":"RT Sasmono","year":"2019","unstructured":"Sasmono, R. T. et al. Multiple introductions of dengue virus strains contribute to dengue outbreaks in East Kalimantan, Indonesia, in 2015\u20132016. Virol. J. 16(1), 93 (2019).","journal-title":"Virol. J."},{"key":"92783_CR86","doi-asserted-by":"publisher","first-page":"8127093","DOI":"10.1155\/2018\/8127093","volume":"2018","author":"TH Sucipto","year":"2018","unstructured":"Sucipto, T. H. et al. Phylogenetic analysis of dengue virus in Bangkalan, Madura Island, East Java Province, Indonesia. J. Trop. Med. 2018, 8127093 (2018).","journal-title":"J. Trop. Med."},{"issue":"6","key":"92783_CR87","doi-asserted-by":"publisher","first-page":"e0178443","DOI":"10.1371\/journal.pone.0178443","volume":"12","author":"P Wardhani","year":"2017","unstructured":"Wardhani, P. et al. Clinical and virological characteristics of dengue in Surabaya, Indonesia. PLoS ONE 12(6), e0178443 (2017).","journal-title":"PLoS ONE"},{"issue":"6","key":"92783_CR88","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.4269\/ajtmh.14-0132","volume":"91","author":"GE Snow","year":"2014","unstructured":"Snow, G. E. et al. Review article: Research on dengue during World War II revisited. Am. J. Trop. Med. Hyg. 91(6), 1203\u20131217 (2014).","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"Pt 3","key":"92783_CR89","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1099\/vir.0.017954-0","volume":"91","author":"SR Kumar","year":"2010","unstructured":"Kumar, S. R. et al. Evolution, dispersal and replacement of American genotype dengue type 2 viruses in India (1956\u20132005): Selection pressure and molecular clock analyses. J. Gen. Virol. 91(Pt 3), 707\u2013720 (2010).","journal-title":"J. Gen. Virol."},{"issue":"8","key":"92783_CR90","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1017\/S0950268814002751","volume":"143","author":"A Shrivastava","year":"2015","unstructured":"Shrivastava, A. et al. Lineage shift of dengue virus in Eastern India: An increased implication for DHF\/DSS. Epidemiol. Infect. 143(8), 1599\u20131605 (2015).","journal-title":"Epidemiol. Infect."},{"issue":"3","key":"92783_CR91","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.bbrc.2013.05.130","volume":"436","author":"PK Dash","year":"2013","unstructured":"Dash, P. K. et al. Complete genome sequencing and evolutionary analysis of Indian isolates of Dengue virus type 2. Biochem. Biophys. Res. Commun. 436(3), 478\u2013485 (2013).","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"92783_CR92","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1017\/S0950268816001990","volume":"145","author":"A Tazeen","year":"2017","unstructured":"Tazeen, A. et al. Occurrence of co-infection with dengue viruses during 2014 in New Delhi, India. Epidemiol. Infect. 145(1), 67\u201377 (2017).","journal-title":"Epidemiol. Infect."},{"issue":"5","key":"92783_CR93","first-page":"584","volume":"141","author":"PV Barde","year":"2015","unstructured":"Barde, P. V. et al. Emergence of dengue in tribal villages of Mandla district, Madhya Pradesh, India. Indian J. Med. Res. 141(5), 584\u2013590 (2015).","journal-title":"Indian J. Med. Res."},{"key":"92783_CR94","doi-asserted-by":"publisher","first-page":"S44","DOI":"10.1016\/j.ijid.2019.04.010","volume":"84","author":"A Kasirajan","year":"2019","unstructured":"Kasirajan, A. et al. Phylogenetic analysis of partial pre-membrane and envelope sequences of dengue viruses circulating in India. Int. J. Infect. Dis. 84, S44\u2013S56 (2019).","journal-title":"Int. J. Infect. Dis."},{"key":"92783_CR95","doi-asserted-by":"publisher","first-page":"103977","DOI":"10.1016\/j.meegid.2019.103977","volume":"75","author":"K Suzuki","year":"2019","unstructured":"Suzuki, K. et al. Genotype replacement of dengue virus type 3 and clade replacement of dengue virus type 2 genotype Cosmopolitan in Dhaka, Bangladesh in 2017. Infect. Genet. Evol. 75, 103977 (2019).","journal-title":"Infect. Genet. Evol."},{"issue":"Suppl 1","key":"92783_CR96","first-page":"S1","volume":"142","author":"BP Gupta","year":"2015","unstructured":"Gupta, B. P. et al. Re-emergence of dengue virus serotype 2 strains in the 2013 outbreak in Nepal. Indian J. Med. Res. 142(Suppl 1), S1-6 (2015).","journal-title":"Indian J. Med. Res."},{"key":"92783_CR97","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.meegid.2015.07.006","volume":"34","author":"S Singh","year":"2015","unstructured":"Singh, S. et al. Phylogenetic study reveals co-circulation of Asian II and Cosmopolitan genotypes of Dengue virus serotype 2 in Nepal during 2013. Infect. Genet. Evol. 34, 402\u2013409 (2015).","journal-title":"Infect. Genet. Evol."},{"issue":"1","key":"92783_CR98","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s13337-015-0279-3","volume":"27","author":"M Akram","year":"2016","unstructured":"Akram, M. & Idrees, M. Complete genome sequencing and comparative analysis of three dengue virus type 2 Pakistani isolates. Virusdisease 27(1), 27\u201333 (2016).","journal-title":"Virusdisease"},{"key":"92783_CR99","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/1743-422X-10-275","volume":"10","author":"C Koo","year":"2013","unstructured":"Koo, C. et al. Evolution and heterogeneity of multiple serotypes of Dengue virus in Pakistan, 2006\u20132011. Virol. J. 10, 275 (2013).","journal-title":"Virol. J."},{"issue":"1","key":"92783_CR100","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.meegid.2011.10.012","volume":"12","author":"KS Lee","year":"2012","unstructured":"Lee, K. S. et al. Dengue virus surveillance in Singapore reveals high viral diversity through multiple introductions and in situ evolution. Infect. Genet. Evol. 12(1), 77\u201385 (2012).","journal-title":"Infect. Genet. Evol."},{"issue":"6","key":"92783_CR101","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.4269\/ajtmh.14-0588","volume":"92","author":"LC Ng","year":"2015","unstructured":"Ng, L. C. et al. 2013 dengue outbreaks in Singapore and Malaysia caused by different viral strains. Am. J. Trop. Med. Hyg. 92(6), 1150\u20131155 (2015).","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"1","key":"92783_CR102","doi-asserted-by":"publisher","first-page":"7345","DOI":"10.1038\/s41598-019-43560-5","volume":"9","author":"H Yu","year":"2019","unstructured":"Yu, H. et al. Multiple lineages of dengue virus serotype 2 cosmopolitan genotype caused a local dengue outbreak in Hangzhou, Zhejiang Province, China, in 2017. Sci. Rep. 9(1), 7345 (2019).","journal-title":"Sci. Rep."},{"key":"92783_CR103","doi-asserted-by":"publisher","first-page":"216","DOI":"10.3389\/fcimb.2018.00216","volume":"8","author":"H Yan","year":"2018","unstructured":"Yan, H. et al. Epidemiological characterization of the 2017 dengue outbreak in Zhejiang, China and molecular characterization of the viruses. Front. Cell Infect. Microbiol. 8, 216 (2018).","journal-title":"Front. Cell Infect. Microbiol."},{"issue":"4","key":"92783_CR104","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1111\/j.1365-3156.2008.02037.x","volume":"13","author":"A Zaki","year":"2008","unstructured":"Zaki, A. et al. Phylogeny of dengue viruses circulating in Jeddah, Saudi Arabia: 1994 to 2006. Trop. Med. Int. Health 13(4), 584\u2013592 (2008).","journal-title":"Trop. Med. Int. Health"},{"issue":"7","key":"92783_CR105","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.3201\/eid2507.180046","volume":"25","author":"KA Alghazali","year":"2019","unstructured":"Alghazali, K. A. et al. Dengue War, Taiz, Yemen. Emerg. Infect. Dis. 25(7), 1397\u20131400 (2019).","journal-title":"Emerg. Infect. Dis."},{"issue":"4","key":"92783_CR106","doi-asserted-by":"publisher","first-page":"e01455","DOI":"10.1016\/j.heliyon.2019.e01455","volume":"5","author":"H Pascalis","year":"2019","unstructured":"Pascalis, H. et al. The epidemic of Dengue virus type-2 Cosmopolitan genotype on Reunion Island relates to its active circulation in the Southwestern Indian Ocean neighboring islands. Heliyon 5(4), e01455 (2019).","journal-title":"Heliyon"},{"issue":"8","key":"92783_CR107","first-page":"1349","volume":"17","author":"A Amarasinghe","year":"2011","unstructured":"Amarasinghe, A. et al. Dengue virus infection in Africa. Emerg. Infect. Dis. 17(8), 1349\u20131354 (2011).","journal-title":"Emerg. Infect. Dis."},{"issue":"7446","key":"92783_CR108","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nature12060","volume":"496","author":"S Bhatt","year":"2013","unstructured":"Bhatt, S. et al. The global distribution and burden of dengue. Nature 496(7446), 504\u2013507 (2013).","journal-title":"Nature"},{"issue":"10","key":"92783_CR109","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3201\/eid2010.140487","volume":"20","author":"T Jaenisch","year":"2014","unstructured":"Jaenisch, T. et al. Dengue expansion in Africa-not recognized or not happening?. Emerg. Infect. Dis. 20(10), 102 (2014).","journal-title":"Emerg. Infect. Dis."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92783-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92783-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92783-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T07:21:45Z","timestamp":1675495305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92783-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,29]]},"references-count":109,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["92783"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-92783-y","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,29]]},"assertion":[{"value":"3 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"13496"}}