{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:30:31Z","timestamp":1793406631525,"version":"4.5.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The frequent coexistence of obesity and metabolic syndrome in patients with alopecia areata may indicate the common pathogenetic pathway in these conditions with an important role of adipokines. The aim of the study was to evaluate the serum level of adiponectin, resistin and leptin in patients with alopecia areata in comparison to healthy controls. The study included 65 patients with alopecia areata and 71 healthy controls. The concentration of adipokines was determined with the enzyme-linked immunosorbent assay. The mean concentrations of adiponectin and resistin were significantly lower in the sera of patients with alopecia areata when compared to healthy controls (7966 <jats:inline-formula><jats:alternatives><jats:tex-math>$$\\pm$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mo>\u00b1<\/mml:mo>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula> 4087 vs 9947 <jats:inline-formula><jats:alternatives><jats:tex-math>$$\\pm$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mo>\u00b1<\/mml:mo>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula> 5692\u00a0ng\/ml;\u00a0p\u2009=\u20090.0312 and 11.04 <jats:inline-formula><jats:alternatives><jats:tex-math>$$\\pm$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mo>\u00b1<\/mml:mo>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula> 3.88 vs 14.11 <jats:inline-formula><jats:alternatives><jats:tex-math>$$\\pm$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mo>\u00b1<\/mml:mo>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula> 8.69\u00a0ng\/ml;\u00a0p\u2009=\u20090.0176, respectively). A negative correlation between the serum level of adiponectin and severity of alopecia tool (SALT) score was observed (r\u2009=\u2009\u2212 0.26; p\u2009&lt;\u20090.05). The concentration of adiponectin was significantly lower in patients with alopecia universalis than in patients with patchy alopecia areata (4951 <jats:inline-formula><jats:alternatives><jats:tex-math>$$\\pm$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mo>\u00b1<\/mml:mo>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula> 2499 vs 8525 <jats:inline-formula><jats:alternatives><jats:tex-math>$$\\pm$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mo>\u00b1<\/mml:mo>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula> 4085\u00a0ng\/ml; p\u2009=\u20090.0135). No significant difference in the serum concentration of leptin was observed between patients with alopecia areata and healthy controls. The negative correlation between the serum level of adiponectin and hair loss severity indicates that adiponectin may be considered a marker of hair loss severity in alopecia areata. Further studies are needed to evaluate the role of resistin in patients with alopecia areata and its decreased level irregardless of severity or activity of the disease.<\/jats:p>","DOI":"10.1038\/s41598-021-92853-1","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T10:04:04Z","timestamp":1625479444000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Adiponectin as a novel biomarker of disease severity in alopecia areata"],"prefix":"10.1038","volume":"11","author":[{"given":"Anna","family":"Stochmal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wa\u015bkiel-Burnat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Chrostowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Zaremba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Rakowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Czuwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Rudnicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,5]]},"reference":[{"key":"92853_CR1","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.jaci.2005.02.023","volume":"115","author":"G Fantuzzi","year":"2005","unstructured":"Fantuzzi, G. Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol. 115, 911\u2013919 (2005).","journal-title":"J. Allergy Clin. Immunol."},{"key":"92853_CR2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.2147\/ITT.S73223","volume":"5","author":"P Mancuso","year":"2016","unstructured":"Mancuso, P. The role of adipokines in chronic inflammation. ImmunoTargets Ther. 5, 47\u201356 (2016).","journal-title":"ImmunoTargets Ther."},{"key":"92853_CR3","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00403-019-01993-y","volume":"312","author":"A Stochmal","year":"2020","unstructured":"Stochmal, A., Czuwara, J., Zaremba, M. & Rudnicka, L. Altered serum level of metabolic and endothelial factors in patients with systemic sclerosis. Arch. Dermatol. Res. 312, 453\u2013458 (2020).","journal-title":"Arch. Dermatol. Res."},{"key":"92853_CR4","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.3390\/nu10091241","volume":"10","author":"J Ambroszkiewicz","year":"2018","unstructured":"Ambroszkiewicz, J. et al. Anti-inflammatory and pro-inflammatory adipokine profiles in children on vegetarian and omnivorous diets. Nutrients 10, 1241 (2018).","journal-title":"Nutrients"},{"key":"92853_CR5","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1096\/fj.08-116327","volume":"23","author":"M Randhawa","year":"2009","unstructured":"Randhawa, M. et al. Evidence for the ectopic synthesis of melanin in human adipose tissue. FASEB J. 23, 835\u2013843 (2009).","journal-title":"FASEB J."},{"key":"92853_CR6","doi-asserted-by":"publisher","first-page":"e21","DOI":"10.1111\/j.1467-789X.2010.00773.x","volume":"12","author":"S Page","year":"2011","unstructured":"Page, S., Chandhoke, V. & Baranova, A. Melanin and melanogenesis in adipose tissue: Possible mechanisms for abating oxidative stress and inflammation?. Obes. Rev. 12, e21-31 (2011).","journal-title":"Obes. Rev."},{"key":"92853_CR7","doi-asserted-by":"publisher","first-page":"90s","DOI":"10.1016\/0022-202X(93)90507-E","volume":"101","author":"A Slominski","year":"1993","unstructured":"Slominski, A. & Paus, R. Melanogenesis is coupled to murine anagen: Toward new concepts for the role of melanocytes and the regulation of melanogenesis in hair growth. J. Invest. Dermatol. 101, 90s-s97 (1993).","journal-title":"J. Invest. Dermatol."},{"key":"92853_CR8","first-page":"457","volume":"21","author":"A Slominski","year":"2000","unstructured":"Slominski, A. & Wortsman, J. Neuroendocrinology of the skin. Endocr. Rev. 21, 457\u2013487 (2000).","journal-title":"Endocr. Rev."},{"key":"92853_CR9","doi-asserted-by":"publisher","first-page":"v, vii, 1","DOI":"10.1007\/978-3-642-19683-6_1","volume":"212","author":"AT Slominski","year":"2012","unstructured":"Slominski, A. T. et al. Sensing the environment: Regulation of local and global homeostasis by the skin\u2019s neuroendocrine system. Adv. Anat. Embryol. Cell Biol. 212, v, vii, 1\u2013115 (2012).","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"92853_CR10","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1096\/fj.04-2079rev","volume":"19","author":"A Slominski","year":"2005","unstructured":"Slominski, A., Wortsman, J. & Tobin, D. J. The cutaneous serotoninergic\/melatoninergic system: Securing a place under the sun. FASEB J. 19, 176\u2013194 (2005).","journal-title":"FASEB J."},{"key":"92853_CR11","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.det.2012.08.010","volume":"31","author":"A Alkhalifah","year":"2013","unstructured":"Alkhalifah, A. Alopecia areata update. Dermatol. Clin. 31, 93\u2013108 (2013).","journal-title":"Dermatol. Clin."},{"key":"92853_CR12","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1001\/archderm.1992.01680150136027","volume":"128","author":"K Safavi","year":"1992","unstructured":"Safavi, K. Prevalence of alopecia areata in the First National Health and Nutrition Examination Survey. Arch. Dermatol. 128, 702 (1992).","journal-title":"Arch. Dermatol."},{"key":"92853_CR13","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1038\/jid.2013.464","volume":"134","author":"SA Mirzoyev","year":"2014","unstructured":"Mirzoyev, S. A., Schrum, A. G., Davis, M. D. P. & Torgerson, R. R. Lifetime incidence risk of alopecia areata estimated at 2.1% by Rochester Epidemiology Project, 1990\u20132009. J. Invest. Dermatol. 134, 1141\u20132 (2014).","journal-title":"J. Invest. Dermatol."},{"key":"92853_CR14","doi-asserted-by":"publisher","first-page":"e214","DOI":"10.1111\/jdv.16936","volume":"35","author":"L Rudnicka","year":"2021","unstructured":"Rudnicka, L. & Wa\u015bkiel-Burnat, A. Systemic aspects of alopecia areata Comment to the article by Lai and Sinclair. J. Eur. Acad. Dermatol. Venereol. 35, e214\u2013e215 (2021).","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"92853_CR15","first-page":"541","volume":"66","author":"R Paus","year":"1993","unstructured":"Paus, R., Slominski, A. & Czarnetzki, B. M. Is alopecia areata an autoimmune-response against melanogenesis-related proteins, exposed by abnormal MHC class I expression in the anagen hair bulb?. Yale J. Biol. Med. 66, 541\u2013554 (1993).","journal-title":"Yale J. Biol. Med."},{"key":"92853_CR16","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/jdv.15279","volume":"33","author":"A Wa\u015bkiel-Burnat","year":"2019","unstructured":"Wa\u015bkiel-Burnat, A. et al. The value of dermoscopy in diagnosing eyebrow loss in patients with alopecia areata and frontal fibrosing alopecia. J. Eur. Acad. Dermatol. Venereol. 33, 213\u2013219 (2019).","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"92853_CR17","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1046\/j.0022-202x.2001.01583.x","volume":"117","author":"A Gilhar","year":"2001","unstructured":"Gilhar, A. et al. Melanocyte-associated T cell epitopes can function as autoantigens for transfer of alopecia areata to human scalp explants on Prkdc(scid) mice. J. Invest. Dermatol. 117, 1357\u20131362 (2001).","journal-title":"J. Invest. Dermatol."},{"key":"92853_CR18","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1097\/MOP.0000000000000375","volume":"28","author":"JF Rork","year":"2016","unstructured":"Rork, J. F., Rashighi, M. & Harris, J. E. Understanding autoimmunity of vitiligo and alopecia areata. Curr. Opin. Pediatr. 28, 463\u2013469 (2016).","journal-title":"Curr. Opin. Pediatr."},{"key":"92853_CR19","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.jaad.2003.09.032","volume":"51","author":"EA Olsen","year":"2004","unstructured":"Olsen, E. A. et al. Alopecia areata investigational assessment guidelines\u2014Part II. National Alopecia Areata Foundation. J. Am. Acad. Dermatol. 51, 440\u20137 (2004).","journal-title":"J. Am. Acad. Dermatol."},{"key":"92853_CR20","doi-asserted-by":"publisher","first-page":"41","DOI":"10.4103\/0019-5154.147786","volume":"60","author":"M Kibar","year":"2015","unstructured":"Kibar, M., Aktan, S. & Bilgin, M. Dermoscopic findings in scalp psoriasis and seborrheic dermatitis; two new signs; signet ring vessel and hidden hair. Indian J. Dermatol. 60, 41\u201345 (2015).","journal-title":"Indian J. Dermatol."},{"key":"92853_CR21","unstructured":"Rudnicka, L. & Wa\u015bkiel-Burnat, A. Systemic aspects of alopecia areata Comment to the article by Lai and Sinclair. J. Eur. Acad. Dermatol. Venereol."},{"key":"92853_CR22","doi-asserted-by":"publisher","first-page":"e128","DOI":"10.1111\/jdv.16864","volume":"35","author":"RRZ Conic","year":"2021","unstructured":"Conic, R. R. Z., Chu, S., Tamashunas, N. L., Damiani, G. & Bergfeld, W. Prevalence of cardiac and metabolic diseases among patients with alopecia areata. J. Eur. Acad. Dermatol. Venereol. 35, e128\u2013e129 (2021).","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"92853_CR23","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3109\/15569527.2012.713418","volume":"32","author":"AS Karadag","year":"2013","unstructured":"Karadag, A. S. et al. Insulin resistance is increased in alopecia areata patients. Cutan. Ocul. Toxicol. 32, 102\u2013106 (2013).","journal-title":"Cutan. Ocul. Toxicol."},{"key":"92853_CR24","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s00403-019-01929-6","volume":"311","author":"M Shahidi-Dadras","year":"2019","unstructured":"Shahidi-Dadras, M., Bahraini, N., Rajabi, F. & Younespour, S. Patients with alopecia areata show signs of insulin resistance. Arch. Dermatol. Res. 311, 529\u2013533 (2019).","journal-title":"Arch. Dermatol. Res."},{"key":"92853_CR25","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s00403-019-01893-1","volume":"311","author":"J \u017b\u00f3\u0142kiewicz","year":"2019","unstructured":"\u017b\u00f3\u0142kiewicz, J., Stochmal, A. & Rudnicka, L. The role of adipokines in systemic sclerosis: A missing link?. Arch. Dermatol. Res. 311, 251\u2013263 (2019).","journal-title":"Arch. Dermatol. Res."},{"key":"92853_CR26","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.cyto.2015.04.004","volume":"75","author":"J Hutcheson","year":"2015","unstructured":"Hutcheson, J. Adipokines influence the inflammatory balance in autoimmunity. Cytokine 75, 272\u2013279 (2015).","journal-title":"Cytokine"},{"key":"92853_CR27","doi-asserted-by":"crossref","first-page":"425068","DOI":"10.1155\/2014\/425068","volume":"2014","author":"A Del Prete","year":"2014","unstructured":"Del Prete, A., Salvi, V. & Sozzani, S. Adipokines as potential biomarkers in rheumatoid arthritis. Mediators Inflamm. 2014, 425068 (2014).","journal-title":"Mediators Inflamm."},{"key":"92853_CR28","first-page":"20","volume":"20","author":"G Serarslan","year":"2020","unstructured":"Serarslan, G., \u00d6zcan, O., Okyay, E., \u00dcnl\u00fc, B. & Karada\u011f, M. Role of adiponectin and leptin in patients with alopecia areata with scalp hair loss. Iran. J. Med. Sci. 20, 20 (2020).","journal-title":"Iran. J. Med. Sci."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92853-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92853-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92853-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T11:05:35Z","timestamp":1670065535000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-92853-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,5]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["92853"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-92853-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,5]]},"assertion":[{"value":"27 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"13809"}}