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The transcription factor delta-FosB (\u0394FosB) plays a critical role in behavior and pathology after chronic use of cocaine. \u0394FosB regulates glutamate receptor signaling and dendritic spine morphology in animal models. This experimental study compared the effects of electroacupuncture (EA) at acupoints LI4 and LI11 with those of another potentially beneficial intervention, gabapentin (GBP), alone or in combination, on reinstatement of cocaine-induced conditioned place preference (CPP) and levels of \u0394FosB and glutamate receptor subunit 2 (GluR2) expression in the nucleus accumbens (NAc). EA at LI4 and LI11 significantly prevented cue-induced cocaine CPP reinstatement, whereas needle insertion without electrical stimulation at these acupoints had no such effect. EA also significantly attenuated cocaine-induced increases in \u0394FosB and GluR2 expression in the NAc. Unexpectedly, these effects were reversed when GBP was combined with EA. Treatment with EA at LI4 and LI11 prevented cocaine-induced increases in dendritic spine density in the NAc core and shell. Our results suggest that EA at LI4 and LI11 may prevent cocaine relapse by modulating \u0394FosB and GluR2 expression, as well as dendritic spine density.<\/jats:p>","DOI":"10.1038\/s41598-021-93014-0","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T10:02:45Z","timestamp":1625133765000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates \u0394FosB and GluR2 expression"],"prefix":"10.1038","volume":"11","author":[{"given":"Ai T. M.","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran V. 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