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We compared, in two medical centers, the clinical and laboratory characteristics of MIS-C, KD and an intermediate group, which met the case definitions of both conditions. MIS-C patients were older, were more likely to be hypotensive, to have significant gastrointestinal symptoms, lymphopenia and thrombocytopenia and to have non-coronary abnormal findings in their echocardiogram. Lymphopenia was an independent predictor of MIS-C. Most of our MIS-C patients responded promptly to corticosteroid therapy. KD incidence in both centers was similar in 2019 and 2020. Although there is clinical overlap between KD and MIS-C, these are separate entities. Lymphopenia clearly differentiates between these entities. MIS-C patients may benefit from corticosteroids as first-line therapy.<\/jats:p>","DOI":"10.1038\/s41598-021-93389-0","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T10:04:04Z","timestamp":1625479444000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Characterizing the differences between multisystem inflammatory syndrome in children and Kawasaki disease"],"prefix":"10.1038","volume":"11","author":[{"given":"Maskit","family":"Bar-Meir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Guri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max E.","family":"Godfrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avram R.","family":"Shack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Hashkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofra","family":"Goldzweig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orli","family":"Megged","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,5]]},"reference":[{"key":"93389_CR1","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/S0140-6736(20)31094-1","volume":"395","author":"S Riphagen","year":"2020","unstructured":"Riphagen, S., Gomez, X., Gonzalez-Martinez, C., Wilkinson, N. & Theocharis, P. Hyperinflammatory shock in children during covid-19 pandemic. The Lancet 395, 1607\u20131608 (2020).","journal-title":"The Lancet"},{"key":"93389_CR2","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1016\/S0140-6736(20)31103-X","volume":"395","author":"L Verdoni","year":"2020","unstructured":"Verdoni, L. et al. An outbreak of severe kawasaki-like disease at the italian epicentre of the SARS-COV-2 epidemic: An observational cohort study. Lancet 395, 1771\u20131778 (2020).","journal-title":"Lancet"},{"key":"93389_CR3","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1001\/jama.2020.10369","volume":"324","author":"E Whittaker","year":"2020","unstructured":"Whittaker, E. et al. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-COV-2. 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