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We aimed to investigate whether CES1 CNVs was associated with susceptibility to non-alcoholic fatty liver disease (NAFLD) in a Chinese Han population. A case\u2013control study was conducted among 303 patients diagnosed with NAFLD and 303 age (\u00b1\u20095) and sex-matched controls from the Affiliated Nanping First Hospital of Fujian Medical University in China\n                    <jats:bold>.<\/jats:bold>\n                    The copy numbers of\n                    <jats:italic>CES1<\/jats:italic>\n                    were measured using TaqMan quantitative real-time polymerase chain reaction (qPCR) and serum CES1 was measured using enzyme-linked immunosorbent assays. The Chi-squared test and a logistic regression model were used to evaluate the association between\n                    <jats:italic>CES1<\/jats:italic>\n                    CNVs and NAFLD susceptibility. The distribution of\n                    <jats:italic>CES1<\/jats:italic>\n                    CNVs showed a higher frequency of CNVs loss (&lt;\u20092) among patients; however, the difference was not significant (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.05). After controlling for other known or suspected risk factors for NAFLD,\n                    <jats:italic>CES1<\/jats:italic>\n                    CNVs loss was significantly associated with greater risk of NAFLD (adjusted OR\u2009=\u20092.75, 95% CI 1.30\u20135.85,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.01); while CES1 CNVs gain (&gt;\u20092) was not. There was a suggestion of an association between increased CES1 serum protein levels and CNVs losses among cases, although this was not statistically significant (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.07). Copy number losses (&lt;\u20092) of\n                    <jats:italic>CES1<\/jats:italic>\n                    contribute to susceptibility to NAFLD in the Chinese Han population.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-93549-2","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T06:04:51Z","timestamp":1625637891000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Copy number variation in the CES1 gene and the risk of non-alcoholic fatty liver in a Chinese Han population"],"prefix":"10.1038","volume":"11","author":[{"given":"Bing bing","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian hui","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He wei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao ling","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin ting","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui quan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi zhu","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-E","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,7]]},"reference":[{"issue":"3","key":"93549_CR1","doi-asserted-by":"publisher","first-page":"245","DOI":"10.7861\/clinmedicine.18-3-245","volume":"18","author":"J Maurice","year":"2018","unstructured":"Maurice, J. & Manousou, P. 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