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This prompts researchers to look for new modes of action to slow down the evolution of herbicide-resistant weeds. This research aims to determine the herbicidal action of thiazolo[3,2-a]pyrimidines derivatives, which are well known as antihypertensive drugs. The phytotoxic effects of ten compounds were investigated using leaf disc discoloration test and seed germination bioassay. At concentrations of 125 to 250\u00a0mg\/L, the 5-(3-Fluoro-phenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester (\n                    <jats:bold>c<\/jats:bold>\n                    ) was highly active against\n                    <jats:italic>Oldenlandia verticillata<\/jats:italic>\n                    and\n                    <jats:italic>Eleusine indica<\/jats:italic>\n                    . At application rates of 1.25 to 2.5\u00a0kg ai\/ha, formulated\n                    <jats:bold>c<\/jats:bold>\n                    demonstrated selective post-emergence and pre-emergence herbicidal activity against\n                    <jats:italic>O. verticillata<\/jats:italic>\n                    ,\n                    <jats:italic>E. indica<\/jats:italic>\n                    and\n                    <jats:italic>Cyperus iria<\/jats:italic>\n                    . In the crop tolerance test, formulated\n                    <jats:bold>c<\/jats:bold>\n                    outperformed the commercial herbicide diuron, with aerobic\n                    <jats:italic>Oryza sativa<\/jats:italic>\n                    being the most tolerant, followed by\n                    <jats:italic>Zea mays<\/jats:italic>\n                    , and\n                    <jats:italic>Brassica rapa<\/jats:italic>\n                    . The addition of calcium chloride partially nullified compound\n                    <jats:bold>c<\/jats:bold>\n                    's inhibitory effects on weed shoot growth, indicating that it has potential as a calcium channel blocker. Compound\n                    <jats:bold>c<\/jats:bold>\n                    acted by triggering electrolyte leakage without affecting photosystem II. These findings imply that\n                    <jats:bold>c<\/jats:bold>\n                    could be explored further as a template for developing new herbicides with novel modes of action.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-93662-2","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T06:02:44Z","timestamp":1625810564000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Herbicidal properties of antihypertensive drugs: calcium channel blockers"],"prefix":"10.1038","volume":"11","author":[{"given":"Hannan Safiyyah Tan Sian Hui","family":"Abdullah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poh Wai","family":"Chia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dzolkhifli","family":"Omar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tse Seng","family":"Chuah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,9]]},"reference":[{"key":"93662_CR1","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1614\/WS-09-102.1","volume":"58","author":"SO Duke","year":"2010","unstructured":"Duke, S. 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