{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:01:22Z","timestamp":1783393282688,"version":"3.54.6"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["18ZR1443400"],"award-info":[{"award-number":["18ZR1443400"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Important Scientific & Technological Project","award":["2018ZX10101002\u2013002"],"award-info":[{"award-number":["2018ZX10101002\u2013002"]}]},{"name":"the Fifth Round of Three\u2013Year Public Health Action Plan of Shanghai","award":["GWV\u201310.1\u2013XK13"],"award-info":[{"award-number":["GWV\u201310.1\u2013XK13"]}]},{"name":"the Forge Ahead Together for Elimination Towards Malaria free China\u2013Myanmar border"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Yingjiang County, which is on the China\u2013Myanmar border, is the main focus for malaria elimination in China. The epidemiological characteristics of malaria in Yingjiang County were analysed in a retrospective analysis. A total of 895 malaria cases were reported in Yingjiang County between 2013 and 2019. The majority of cases occurred in males (70.7%) and individuals aged 19\u201359\u00a0years (77.3%). <jats:italic>Plasmodium vivax<\/jats:italic> was the predominant species (96.6%). The number of indigenous cases decreased gradually and since 2017, no indigenous cases have been reported. Malaria cases were mainly distributed in the southern and southwestern areas of the county; 55.6% of the indigenous cases were reported in Nabang Township, which also had the highest risk of imported malaria. The \u201c1\u20133\u20137\u201d approach has been implemented effectively, with 100% of cases reported within 24\u00a0h, 88.9% cases investigated and confirmed within 3\u00a0days and 98.5% of foci responded to within 7\u00a0days. Although malaria elimination has been achieved in Yingjiang County, sustaining elimination and preventing the re-establishment of malaria require the continued strengthening of case detection, surveillance and response systems targeting the migrant population in border areas.<\/jats:p>","DOI":"10.1038\/s41598-021-93734-3","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T10:04:40Z","timestamp":1625738680000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A retrospective analysis of malaria epidemiological characteristics in Yingjiang County on the China\u2013Myanmar border"],"prefix":"10.1038","volume":"11","author":[{"given":"Fang","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Rui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Gui","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui-Sen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Ning","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Nong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,8]]},"reference":[{"key":"93734_CR1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/B978-0-12-800869-0.00002-0","volume":"86","author":"XN Zhou","year":"2014","unstructured":"Zhou, X. N. et al. Feasibility and roadmap analysis for malaria elimination in China. Adv. Parasitol. 86, 21\u201346 (2014).","journal-title":"Adv. Parasitol."},{"key":"93734_CR2","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/bs.apar.2020.03.005","volume":"110","author":"X Feng","year":"2020","unstructured":"Feng, X. et al. The contributions and achievements on malaria control and forthcoming elimination in China over the past 70 years by NIPD-CTDR. Adv. Parasitol. 110, 63\u2013105 (2020).","journal-title":"Adv. Parasitol."},{"key":"93734_CR3","doi-asserted-by":"publisher","first-page":"806","DOI":"10.4269\/ajtmh.15-0888","volume":"95","author":"J Feng","year":"2016","unstructured":"Feng, J. et al. Towards malaria elimination: monitoring and evaluation of the \u201c1\u20133\u20137\u201d approach at the China\u2013Myanmar border. Am. J. Trop. Med. Hyg. 95, 806\u2013810 (2016).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"93734_CR4","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s40249-016-0146-5","volume":"5","author":"T Hu","year":"2016","unstructured":"Hu, T. et al. Shrinking the malaria map in China: measuring the progress of the National Malaria Elimination Programme. Infect. Dis. Poverty 5, 52 (2016).","journal-title":"Infect. Dis. Poverty"},{"key":"93734_CR5","first-page":"289","volume":"50","author":"WZ Yang","year":"2016","unstructured":"Yang, W. Z. & Zhou, X. N. New challenges of malaria elimination in China. Zhonghua Yu Fang Yi Xue Za Zhi 50, 289\u2013291 (2016).","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"93734_CR6","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1186\/s12936-018-2444-9","volume":"17","author":"J Feng","year":"2018","unstructured":"Feng, J. et al. Ready for malaria elimination: zero indigenous case reported in the People\u2019s Republic of China. Malar. J. 17, 315 (2018).","journal-title":"Malar. J."},{"key":"93734_CR7","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1093\/infdis\/jix106","volume":"216","author":"E Lo","year":"2017","unstructured":"Lo, E. et al. Frequent Spread of Plasmodium vivax malaria maintains high genetic diversity at the Myanmar-China border, without distance and landscape barriers. J. Infect. Dis. 216, 1254\u20131263 (2017).","journal-title":"J. Infect. Dis."},{"key":"93734_CR8","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1186\/s12936-016-1590-1","volume":"15","author":"Q Zhang","year":"2016","unstructured":"Zhang, Q. et al. Risk assessment of malaria in land border regions of China in the context of malaria elimination. Malar. J. 15, 546 (2016).","journal-title":"Malar. J."},{"key":"93734_CR9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/B978-0-12-800869-0.00003-2","volume":"86","author":"ZG Xia","year":"2014","unstructured":"Xia, Z. G. et al. Lessons from malaria control to elimination: case study in Hainan and Yunnan provinces. Adv. Parasitol. 86, 47\u201379 (2014).","journal-title":"Adv. Parasitol."},{"key":"93734_CR10","first-page":"819","volume":"43","author":"J Xu","year":"2012","unstructured":"Xu, J. & Liu, H. The challenges of malaria elimination in Yunnan Province, People\u2019s Republic of China. . Southeast Asian J. Trop. Med. Public Health 43, 819\u2013824 (2012).","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"93734_CR11","first-page":"401","volume":"29","author":"SS Zhou","year":"2011","unstructured":"Zhou, S. S., Wang, Y. & Li, Y. Malaria situation in the People\u2019s Republic of China in 2010. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 29, 401\u2013403 (2011).","journal-title":"Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi"},{"key":"93734_CR12","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s40249-016-0175-0","volume":"5","author":"J Zhang","year":"2016","unstructured":"Zhang, J. et al. Effectiveness and impact of the cross-border healthcare model as implemented by non-governmental organizations: case study of the malaria control programs by health poverty action on the China\u2013Myanmar border. Infect. Dis. Poverty 5, 80 (2016).","journal-title":"Infect. Dis. Poverty"},{"key":"93734_CR13","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s40249-020-00777-1","volume":"9","author":"F Huang","year":"2020","unstructured":"Huang, F. et al. From control to elimination: a spatial-temporal analysis of malaria along the China\u2013Myanmar border. Infect Dis Poverty 9, 158 (2020).","journal-title":"Infect Dis Poverty"},{"key":"93734_CR14","first-page":"430","volume":"34","author":"CL Zhang","year":"2016","unstructured":"Zhang, C. L. et al. Evaluation on malaria hotspots in Yingjiang County of the China\u2013Myanmar border area in 2015. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 34, 430\u2013434 (2016).","journal-title":"Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi"},{"key":"93734_CR15","doi-asserted-by":"publisher","first-page":"e0195032","DOI":"10.1371\/journal.pone.0195032","volume":"13","author":"H Liu","year":"2018","unstructured":"Liu, H., Xu, J. W. & Bi, Y. Malaria burden and treatment targets in Kachin Special Region II, Myanmar from 2008 to 2016: A retrospective analysis. PLoS ONE 13, e0195032 (2018).","journal-title":"PLoS ONE"},{"key":"93734_CR16","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3201\/eid0602.000202","volume":"6","author":"P Martens","year":"2000","unstructured":"Martens, P. & Hall, L. Malaria on the move: human population movement and malaria transmission. Emerg. Infect. Dis. 6, 103\u2013109 (2000).","journal-title":"Emerg. Infect. Dis."},{"key":"93734_CR17","unstructured":"WHO. China\u2019s road to malaria elimination. (2019)."},{"key":"93734_CR18","first-page":"483","volume":"32","author":"C Wei","year":"2020","unstructured":"Wei, C. et al. Epidemic situation of malaria in Yunnan Province from 2014 to 2019. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 32, 483\u2013488 (2020).","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"},{"key":"93734_CR19","doi-asserted-by":"publisher","first-page":"e1007707","DOI":"10.1371\/journal.pcbi.1007707","volume":"16","author":"I Routledge","year":"2020","unstructured":"Routledge, I. et al. Tracking progress towards malaria elimination in China: Individual-level estimates of transmission and its spatiotemporal variation using a diffusion network approach. PLoS Comput. Biol. 16, e1007707 (2020).","journal-title":"PLoS Comput. Biol."},{"key":"93734_CR20","doi-asserted-by":"publisher","first-page":"793","DOI":"10.4269\/ajtmh.19-0854","volume":"103","author":"X Zhao","year":"2020","unstructured":"Zhao, X. et al. Malaria risk map using spatial multi-criteria decision analysis along Yunnan border during the pre-elimination period. Am. J. Trop. Med. Hyg. 103, 793\u2013809 (2020).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"93734_CR21","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1186\/s12936-016-1413-4","volume":"15","author":"JW Xu","year":"2016","unstructured":"Xu, J. W. & Liu, H. The relationship of malaria between Chinese side and Myanmar\u2019s five special regions along China\u2013Myanmar border: a linear regression analysis. Malar. J. 15, 368 (2016).","journal-title":"Malar. J."},{"key":"93734_CR22","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s40249-017-0322-2","volume":"6","author":"B Shi","year":"2017","unstructured":"Shi, B. et al. Risk assessment of malaria transmission at the border area of China and Myanmar. Infect. Dis. Poverty 6, 108 (2017).","journal-title":"Infect. Dis. Poverty"},{"key":"93734_CR23","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1186\/s12936-017-2126-z","volume":"16","author":"T Chen","year":"2017","unstructured":"Chen, T. et al. Receptivity to malaria in the China\u2013Myanmar border in Yingjiang County, Yunnan Province China.  Malar. J. 16, 478 (2017).","journal-title":"Malar. J."},{"key":"93734_CR24","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1186\/s13071-018-3073-4","volume":"11","author":"SS Zhang","year":"2018","unstructured":"Zhang, S. S. et al. Monitoring of malaria vectors at the China\u2013Myanmar border while approaching malaria elimination. Parasit. Vectors 11, 511 (2018).","journal-title":"Parasit. Vectors"},{"key":"93734_CR25","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4269\/ajtmh.16-0141","volume":"95","author":"RE Howes","year":"2016","unstructured":"Howes, R. E. et al. Global epidemiology of Plasmodium vivax. Am. J. Trop. Med. Hyg. 95, 15\u201334 (2016).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"93734_CR26","doi-asserted-by":"publisher","first-page":"97","DOI":"10.4269\/ajtmh.2001.64.97","volume":"64","author":"K Mendis","year":"2001","unstructured":"Mendis, K., Sina, B. J., Marchesini, P. & Carter, R. The neglected burden of Plasmodium vivax malaria. Am. J. Trop. Med. Hyg. 64, 97\u2013106 (2001).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"93734_CR27","unstructured":"WHO. World malaria report 2019. (2019)."},{"key":"93734_CR28","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s12936-020-03221-9","volume":"19","author":"Y Li","year":"2020","unstructured":"Li, Y. et al. Dynamics of Plasmodium vivax populations in border areas of the Greater Mekong sub-region during malaria elimination. Malar J 19, 145. https:\/\/doi.org\/10.1186\/s12936-020-03221-9 (2020).","journal-title":"Malar J"},{"key":"93734_CR29","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1186\/s12936-019-2835-6","volume":"18","author":"N Kaehler","year":"2019","unstructured":"Kaehler, N. et al. Prospects and strategies for malaria elimination in the Greater Mekong Sub-region: a qualitative study. Malar. J. 18, 203 (2019).","journal-title":"Malar. J."},{"key":"93734_CR30","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12864-017-3523-y","volume":"18","author":"SB Chen","year":"2017","unstructured":"Chen, S. B. et al. Whole-genome sequencing of a Plasmodium vivax clinical isolate exhibits geographical characteristics and high genetic variation in China\u2013Myanmar border area. BMC Genomics 18, 131 (2017).","journal-title":"BMC Genomics"},{"key":"93734_CR31","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.actatropica.2011.02.016","volume":"121","author":"L Cui","year":"2012","unstructured":"Cui, L. et al. Malaria in the Greater Mekong Subregion: heterogeneity and complexity. Acta. Trop. 121, 227\u2013239 (2012).","journal-title":"Acta. Trop."},{"key":"93734_CR32","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s12936-017-1707-1","volume":"16","author":"D Wang","year":"2017","unstructured":"Wang, D. et al. Adapting the local response for malaria elimination through evaluation of the 1-3-7 system performance in the China\u2013Myanmar border region. Malar. J. 16, 54 (2017).","journal-title":"Malar. J."},{"key":"93734_CR33","unstructured":"WHO. Malaria surveillance, monitoring & evaluation: a reference manual. (2018)."},{"key":"93734_CR34","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s40249-020-0632-7","volume":"9","author":"PP Aung","year":"2020","unstructured":"Aung, P. P. et al. Challenges in early phase of implementing the 1-3-7 surveillance and response approach in malaria elimination setting: A field study from Myanmar. Infect. Dis. Poverty 9, 18 (2020).","journal-title":"Infect. Dis. Poverty"},{"key":"93734_CR35","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1186\/s12889-020-08634-4","volume":"20","author":"ST Kheang","year":"2020","unstructured":"Kheang, S. T. et al. Malaria elimination using the 1-3-7 approach: lessons from Sampov Loun Cambodia. BMC Public Health 20, 544 (2020).","journal-title":"BMC Public Health"},{"key":"93734_CR36","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1186\/s12936-021-03740-z","volume":"20","author":"C Lertpiriyasuwat","year":"2021","unstructured":"Lertpiriyasuwat, C. et al. Implementation and success factors from Thailand\u2019s 1\u20133\u20137 surveillance strategy for malaria elimination. Malar. J. 20, 201 (2021).","journal-title":"Malar. J."},{"key":"93734_CR37","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s12936-021-03668-4","volume":"20","author":"NJ Arisco","year":"2021","unstructured":"Arisco, N. J., Peterka, C. & Castro, M. C. Cross-border malaria in Northern Brazil. Malar. J. 20, 135 (2021).","journal-title":"Malar. J."},{"key":"93734_CR38","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s12936-015-0712-5","volume":"14","author":"DM Parker","year":"2015","unstructured":"Parker, D. M. et al. Microgeography and molecular epidemiology of malaria at the Thailand-Myanmar border in the malaria pre-elimination phase. Malar. J. 14, 198 (2015).","journal-title":"Malar. J."},{"key":"93734_CR39","doi-asserted-by":"publisher","first-page":"e1001398","DOI":"10.1371\/journal.pmed.1001398","volume":"10","author":"VI Carrara","year":"2013","unstructured":"Carrara, V. I. et al. Malaria burden and artemisinin resistance in the mobile and migrant population on the Thai-Myanmar border, 1999\u20132011: an observational study. PLoS Med. 10, e1001398 (2013).","journal-title":"PLoS Med."},{"key":"93734_CR40","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S1473-3099(20)30700-3","volume":"21","author":"DJ Weiss","year":"2021","unstructured":"Weiss, D. J. et al. Indirect effects of the COVID-19 pandemic on malaria intervention coverage, morbidity, and mortality in Africa: a geospatial modelling analysis. Lancet Infect. Dis. 21, 59\u201369 (2021).","journal-title":"Lancet Infect. Dis."},{"key":"93734_CR41","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1186\/s12916-020-01710-x","volume":"18","author":"SJ Rogerson","year":"2020","unstructured":"Rogerson, S. J. et al. Identifying and combating the impacts of COVID-19 on malaria. BMC Med. 18, 239 (2020).","journal-title":"BMC Med."},{"key":"93734_CR42","doi-asserted-by":"publisher","first-page":"546","DOI":"10.4269\/ajtmh.14-0321","volume":"92","author":"JW Xu","year":"2015","unstructured":"Xu, J. W., Liu, H., Zhang, Y., Guo, X. R. & Wang, J. Z. Risk factors for border malaria in a malaria elimination setting: a retrospective case-control study in Yunnan, China.  Am. J. Trop. Med. Hyg. 92, 546\u2013551 (2015).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"93734_CR43","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/j.pt.2017.06.010","volume":"33","author":"S Zhang","year":"2017","unstructured":"Zhang, S. et al. Anopheles vectors in mainland China while approaching malaria elimination. Trends Parasitol. 33, 889\u2013900 (2017).","journal-title":"Trends Parasitol."},{"key":"93734_CR44","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.jinf.2015.08.010","volume":"71","author":"BK Bai","year":"2015","unstructured":"Bai, B. K., Xu, Z. & Shen, H. H. Infectious disease surveillance in China. J. Infect. 71, 698\u2013700 (2015).","journal-title":"J. Infect."},{"key":"93734_CR45","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1472-6947-12-4","volume":"12","author":"WR Yan","year":"2012","unstructured":"Yan, W. R. et al. Establishing a web-based integrated surveillance system for early detection of infectious disease epidemic in rural China: a field experimental study. BMC Med. Inform Decis. Mak. 12, 4 (2012).","journal-title":"BMC Med. Inform Decis. Mak."},{"key":"93734_CR46","unstructured":"National Health Commission of the People's Republic of China. Diagnosis of malaria (WS259\u20132015), Beijing (2016)."},{"key":"93734_CR47","unstructured":"National Health Commission of the People's Republic of China. Technical Programme for Malaria Elimination, Beijing (2011)."},{"key":"93734_CR48","unstructured":"R\u00a0Core Team.\u00a0R: A language and environment for statistical computing.\u00a0R\u00a0Foundation for Statistical Computing, Vienna, Austria. https:\/\/www.R-project.org\/ (2020)."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-93734-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-93734-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-93734-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T11:00:13Z","timestamp":1670065213000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-93734-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,8]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["93734"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-93734-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,8]]},"assertion":[{"value":"21 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14129"}}