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This study aimed to investigate LCPUFA status in severe preeclampsia and preterm birth. A cross sectional study was conducted in 104 pregnant women, which divided into normal pregnancy, severe preeclampsia and preterm birth groups. Serum percentage and concentration of total LCPUFA, omega-3, alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), omega-6, linoleic acid (LA), and arachidonic acid (AA) were measured using gas chromatography\/mass spectrometry. Receiver operating characteristic (ROC), bivariate and multivariate analysis were performed. Severe preeclampsia showed the highest concentration of total PUFA and the lowest DHA percentage, with significantly higher Omega-6\/Omega-3 ratio (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004) and lower omega-3 index (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.002) compared to control. Preterm birth showed the least omega-3 concentrations, with significantly low omega-6 derivates (LA (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014) and AA (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.025)) compared to control. LCPUFA parameters have shown to increase the risk in both conditions, particularly ALA\u2009\u2264\u200953\u00a0\u00b5mol\/L in preeclampsia with OR 5.44, 95%CI 1.16\u201325.42 and preterm birth with OR 4.68, 95%CI 1.52\u201314.38. These findings suggest that severe preeclampsia and preterm birth have an imbalance in LCPUFA status.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-93846-w","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T06:03:18Z","timestamp":1626674598000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Long-chain polyunsaturated fatty acid (LC-PUFA) status in severe preeclampsia and preterm birth: a cross sectional study"],"prefix":"10.1038","volume":"11","author":[{"given":"Rima","family":"Irwinda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabbania","family":"Hiksas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aprilia Asthasari","family":"Siregar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudianto Budi","family":"Saroyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noroyono","family":"Wibowo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"93846_CR1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.plefa.2016.08.010","volume":"113","author":"GE Leghi","year":"2016","unstructured":"Leghi, G. 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