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We investigated the prognostic significance of hepatorenal dysfunction in 172 consecutive patients undergoing transcatheter tricuspid valve repair (TTVR). The model for end-stage liver disease excluding international normalized ratio (MELD-XI) score was calculated as 5.11\u2009\u00d7\u2009ln(serum total bilirubin [mg\/dl])\u2009+\u200911.76\u2009\u00d7\u2009ln(serum creatinine [mg\/dl])\u2009+\u20099.44. Patients were stratified into two groups: high (\u2265\u200914) or low (&lt;\u200914) MELD-XI score, according to the best cut-off value to predict a one-year composite outcome consisting of all-cause mortality and HF hospitalization. Compared to patients with low MELD-XI score (n\u2009=\u2009121), patients with high MELD-XI score (n\u2009=\u200951) had a higher incidence of the composite outcome (47.1% vs. 17.4%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). In the multivariable analysis, the MELD-XI score was an independent predictor of the composite outcome (adjusted hazard ratio: 1.12; 95% confidence interval [CI] 1.05\u20131.19; <jats:italic>p<\/jats:italic>\u2009=\u20090.0003). In addition, post-procedural TR\u2009&lt;\u20093\u2009+\u2009after TTVR was independently associated with a reduction in MELD-XI score six months after TTVR (adjusted odds ratio: 3.37; 95% CI 1.09\u201310.40; <jats:italic>p<\/jats:italic>\u2009=\u20090.03). Thus, the MELD-XI score was associated with the risk of one-year composite outcome, consisting of mortality and HF hospitalization, after TTVR and may help the risk stratification in patients undergoing TTVR.<\/jats:p>","DOI":"10.1038\/s41598-021-93952-9","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T10:24:02Z","timestamp":1626171842000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prognostic impact of hepatorenal function in patients undergoing transcatheter tricuspid valve repair"],"prefix":"10.1038","volume":"11","author":[{"given":"Tetsu","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Refik","family":"Kavsur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Vogelhuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5419-2488","authenticated-orcid":false,"given":"Can","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedat","family":"Tiyerili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Nickenig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Ulrich","family":"Becher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"93952_CR1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/ehjci\/jez216","volume":"21","author":"E Chorin","year":"2020","unstructured":"Chorin, E. et al. 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Marcel Weber has received lecture or proctoring fees from Abbott, Boehringer-Ingelheim, Edwards Lifesciences, Janssen, Neochord, Pfizer, and Servier. Tetsu Tanaka was financially supported in part by a Fellowship from the Japanese College of Cardiology. All other authors report no relationship with industry and other entities.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14420"}}