{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:30:50Z","timestamp":1792791050558,"version":"4.5.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The Japan Ministry of Defense","award":["a Grant for Advanced Defense Medical Research A-4"],"award-info":[{"award-number":["a Grant for Advanced Defense Medical Research A-4"]}],"id":[{"id":"https:\/\/ror.org\/05pj88q26","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Japan Ministry of Defense","award":["a Grant for Advanced Defense Medical Research A-4"],"award-info":[{"award-number":["a Grant for Advanced Defense Medical Research A-4"]}],"id":[{"id":"https:\/\/ror.org\/05pj88q26","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Japan Ministry of Defense","award":["a Grant for Advanced Defense Medical Research A-4"],"award-info":[{"award-number":["a Grant for Advanced Defense Medical Research A-4"]}],"id":[{"id":"https:\/\/ror.org\/05pj88q26","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Japan Ministry of Defense","award":["a Grant for Advanced Defense Medical Research A-4"],"award-info":[{"award-number":["a Grant for Advanced Defense Medical Research A-4"]}],"id":[{"id":"https:\/\/ror.org\/05pj88q26","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Japan Ministry of Defense","award":["a Grant for Advanced Defense Medical Research A-4"],"award-info":[{"award-number":["a Grant for Advanced Defense Medical Research A-4"]}],"id":[{"id":"https:\/\/ror.org\/05pj88q26","id-type":"ROR","asserted-by":"crossref"}]},{"name":"JSPS KAKENHI","award":["18K09335"],"award-info":[{"award-number":["18K09335"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Blast exposure can induce various types of hearing impairment, including permanent hearing loss, tinnitus, and hyperacusis. Herein, we conducted a detailed investigation of the cochlear pathophysiology in blast-induced hearing loss in mice using two blasts with different characteristics: a low-frequency dominant blast generated by a shock tube and a high-frequency dominant shock wave generated by laser irradiation (laser-induced shock wave). The pattern of sensorineural hearing loss (SNHL) was low-frequency- and high-frequency-dominant in response to the low- and high-frequency blasts, respectively. Pathological examination revealed that cochlear synaptopathy was the most frequent cochlear pathology after blast exposure, which involved synapse loss in the inner hair cells without hair cell loss, depending on the power spectrum of the blast. This pathological change completely reflected the physiological analysis of wave I amplitude using auditory brainstem responses. Stereociliary bundle disruption in the outer hair cells was also dependent on the blast\u2019s power spectrum. Therefore, we demonstrated that the dominant frequency of the blast power spectrum was the principal factor determining the region of cochlear damage. We believe that the presenting models would be valuable both in blast research and the investigation of various types of hearing loss whose pathogenesis involves cochlear synaptopathy.<\/jats:p>","DOI":"10.1038\/s41598-021-94080-0","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T06:03:18Z","timestamp":1626674598000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effect of shock wave power spectrum on the inner ear pathophysiology in blast-induced hearing loss"],"prefix":"10.1038","volume":"11","author":[{"given":"Eiko","family":"Kimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunio","family":"Mizutari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaomi","family":"Kurioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Kawauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Shiotani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"94080_CR1","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/S0140-6736(09)60257-9","volume":"374","author":"SJ Wolf","year":"2009","unstructured":"Wolf, S. J., Bebarta, V. S., Bonnett, C. J., Pons, P. T. & Cantrill, S. V. Blast injuries. Lancet 374, 405\u2013415 (2009).","journal-title":"Lancet"},{"key":"94080_CR2","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1682\/JRRD.2010.09.0166","volume":"49","author":"FJ Gallun","year":"2012","unstructured":"Gallun, F. J. et al. Implications of blast exposure for central auditory function: a review. J. Rehabil. Res. Dev. 49, 1059\u20131074 (2012).","journal-title":"J. Rehabil. Res. Dev."},{"key":"94080_CR3","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1002\/lary.24169","volume":"124","author":"A Shah","year":"2014","unstructured":"Shah, A., Ayala, M., Capra, G., Fox, D. & Hoffer, M. Otologic assessment of blast and nonblast injury in returning Middle East-deployed service members. Laryngoscope. 124, 272\u2013277 (2014).","journal-title":"Laryngoscope."},{"key":"94080_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.heares.2017.04.010","volume":"349","author":"K Yankaskas","year":"2017","unstructured":"Yankaskas, K., Hammill, T., Packer, M. & Zuo, J. Editorial: Auditory injury\u2014a military perspective. Hear. Res. 349, 1\u20133 (2017).","journal-title":"Hear. Res."},{"key":"94080_CR5","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1631\/jzus.B1700051","volume":"20","author":"K Mizutari","year":"2019","unstructured":"Mizutari, K. Blast-induced hearing loss. J. Zhejiang. Univ. Sci. B. 20, 111\u2013115 (2019).","journal-title":"J. Zhejiang. Univ. Sci. B."},{"key":"94080_CR6","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1097\/MOO.0000000000000563","volume":"27","author":"K Mizutari","year":"2019","unstructured":"Mizutari, K. Update on treatment options for blast-induced hearing loss. Curr. Opin. Otolaryngol. Head. Neck. Surg. 27, 376\u2013380 (2019).","journal-title":"Curr. Opin. Otolaryngol. Head. Neck. Surg."},{"key":"94080_CR7","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.amjsurg.2005.08.022","volume":"190","author":"V Avidan","year":"2005","unstructured":"Avidan, V. et al. Blast lung injury: clinical manifestations, treatment, and outcome. Am. J. Surg. 190, 927\u2013931 (2005).","journal-title":"Am. J. Surg."},{"key":"94080_CR8","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1097\/00000658-198904000-00016","volume":"209","author":"E Katz","year":"1989","unstructured":"Katz, E., Ofek, B., Adler, J., Abramowitz, H. B. & Krausz, M. M. Primary blast injury after a bomb explosion in a civilian bus. Ann. Surg. 209, 484\u2013488 (1989).","journal-title":"Ann. Surg."},{"key":"94080_CR9","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1097\/MAO.0000000000000616","volume":"35","author":"AK Remenschneider","year":"2014","unstructured":"Remenschneider, A. K. et al. Otologic outcomes after blast injury: the Boston Marathon experience. Otol. Neurotol. 35, 1825\u20131834 (2014).","journal-title":"Otol. Neurotol."},{"key":"94080_CR10","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1097\/MAO.0000000000002012","volume":"39","author":"G Van Haesendonck","year":"2018","unstructured":"Van Haesendonck, G., Van Rompaey, V., Gilles, A., Topsakal, V. & Van de Heyning, P. Otologic outcomes after blast injury: the Brussels bombing experience. Otol. Neurotol. 39, 1250\u20131255 (2018).","journal-title":"Otol. Neurotol."},{"key":"94080_CR11","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1080\/14992020400050025","volume":"43","author":"R Mrena","year":"2004","unstructured":"Mrena, R., Savolainen, S., Pirvola, U. & Ylikoski, J. Characteristics of acute acoustical trauma in the Finnish defence forces. Int. J. Audiol. 43, 177\u2013181 (2004).","journal-title":"Int. J. Audiol."},{"key":"94080_CR12","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1682\/JRRD.2008.09.0118","volume":"46","author":"SA Fausti","year":"2009","unstructured":"Fausti, S. A., Wilmington, D. J., Gallun, F. J., Myers, P. J. & Henry, J. A. Auditory and vestibular dysfunction associated with blast-related traumatic brain injury. J. Rehabil. Res. Dev. 46, 797\u2013810 (2009).","journal-title":"J. Rehabil. Res. Dev."},{"key":"94080_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067618","volume":"8","author":"SI Cho","year":"2013","unstructured":"Cho, S. I. et al. Mechanisms of hearing loss after blast injury to the ear. PLoS ONE 8, e67618. https:\/\/doi.org\/10.1371\/journal.pone.0067618 (2013).","journal-title":"PLoS ONE"},{"key":"94080_CR14","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1089\/neu.2011.1934","volume":"29","author":"JC Mao","year":"2012","unstructured":"Mao, J. C. et al. Blast-induced tinnitus and hearing loss in rats: behavioral and imaging assays. J. Neurotrauma. 29, 430\u2013444 (2012).","journal-title":"J. Neurotrauma."},{"key":"94080_CR15","doi-asserted-by":"publisher","first-page":"10740","DOI":"10.1038\/s41598-018-28924-7","volume":"8","author":"TT Hickman","year":"2018","unstructured":"Hickman, T. T., Smalt, C., Bobrow, J., Quatieri, T. & Liberman, M. C. Blast-induced cochlear synaptopathy in chinchillas. Sci. Rep. 8, 10740. https:\/\/doi.org\/10.1038\/s41598-018-28924-7 (2018).","journal-title":"Sci. Rep."},{"key":"94080_CR16","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jneumeth.2015.01.009","volume":"242","author":"AJ Newman","year":"2015","unstructured":"Newman, A. J. et al. Low-cost blast wave generator for studies of hearing loss and brain injury: blast wave effects in closed spaces. J. Neurosci. Methods. 242, 82\u201392 (2015).","journal-title":"J. Neurosci. Methods."},{"key":"94080_CR17","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1093\/milmed\/usz309","volume":"185","author":"KD Smith","year":"2020","unstructured":"Smith, K. D., Chen, T. & Gan, R. Z. Hearing damage induced by blast overpressure at mild tbi level in a Chinchilla model. Mil. Med. 185, 248\u2013255 (2020).","journal-title":"Mil. Med."},{"key":"94080_CR18","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1093\/jnen\/nly060","volume":"77","author":"Y Satoh","year":"2018","unstructured":"Satoh, Y. et al. Molecular hydrogen prevents social deficits and depression-like behaviors induced by low-intensity blast in mice. J. Neuropathol. Exp. Neurol. 77, 827\u2013836 (2018).","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"94080_CR19","doi-asserted-by":"publisher","first-page":"31754","DOI":"10.1038\/srep31754","volume":"6","author":"K Niwa","year":"2016","unstructured":"Niwa, K. et al. Pathophysiology of the inner ear after blast injury caused by laser-induced shock wave. Sci. Rep. 6, 31754. https:\/\/doi.org\/10.1038\/srep31754 (2016).","journal-title":"Sci. Rep."},{"key":"94080_CR20","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.anl.2020.07.019","volume":"48","author":"K Niwa","year":"2021","unstructured":"Niwa, K. et al. Tinnitus rat model generated by laser-induced shock wave; a platform for analyzing the central nervous system after tinnitus generation. Auris Nasus Larynx 48, 82\u201389 (2021).","journal-title":"Auris Nasus Larynx"},{"key":"94080_CR21","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/cne.902380106","volume":"238","author":"I Stiebler","year":"1985","unstructured":"Stiebler, I. & Ehret, G. Inferior colliculus of the house mouse. I. A quantitative study of tonotopic organization, frequency representation, and tone-threshold distribution. J. Comp. Neurol. 238, 65\u201376 (1985).","journal-title":"J. Comp. Neurol."},{"key":"94080_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.heares.2004.04.016","volume":"197","author":"A Viberg","year":"2004","unstructured":"Viberg, A. & Canlon, B. The guide to plotting a cochleogram. Hear. Res. 197, 1\u201310. https:\/\/doi.org\/10.1016\/j.heares.2004.04.016 (2004).","journal-title":"Hear. Res."},{"key":"94080_CR23","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1126\/science.1145206","volume":"189","author":"JS Buchwald","year":"1975","unstructured":"Buchwald, J. S. & Huang, C. Far-field acoustic response: origins in the cat. Science 189, 382\u2013384 (1975).","journal-title":"Science"},{"key":"94080_CR24","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1121\/1.426948","volume":"105","author":"CA Shera","year":"1999","unstructured":"Shera, C. A. & Guinan, J. J. Jr. Evoked otoacoustic emissions arise by two fundamentally different mechanisms: a taxonomy for mammalian OAEs. J. Acoust. Soc. Am. 105, 782\u2013798 (1999).","journal-title":"J. Acoust. Soc. Am."},{"key":"94080_CR25","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/nature03418","volume":"434","author":"D Khimich","year":"2005","unstructured":"Khimich, D. et al. Hair cell synaptic ribbons are essential for synchronous auditory signalling. Nature 434, 889\u2013894 (2005).","journal-title":"Nature"},{"key":"94080_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125160","volume":"10","author":"JB Jensen","year":"2015","unstructured":"Jensen, J. B., Lysaght, A. C., Liberman, M. C., Qvortrup, K. & Stankovic, K. M. Immediate and delayed cochlear neuropathy after noise exposure in pubescent mice. PLoS ONE 10, e0125160. https:\/\/doi.org\/10.1371\/journal.pone.0125160 (2015).","journal-title":"PLoS ONE"},{"key":"94080_CR27","first-page":"505","volume":"21","author":"BA Bohne","year":"2000","unstructured":"Bohne, B. A. & Harding, G. W. Degeneration in the cochlea after noise damage: primary versus secondary events. Am. J. Otol. 21, 505\u2013509 (2000).","journal-title":"Am. J. Otol."},{"key":"94080_CR28","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.heares.2006.12.012","volume":"225","author":"GW Harding","year":"2007","unstructured":"Harding, G. W. & Bohne, B. A. Distribution of focal lesions in the chinchilla organ of Corti following exposure to a 4-kHz or a 0.5-kHz octave band of noise. Hear. Res. 225, 50\u201359 (2007).","journal-title":"Hear. Res."},{"key":"94080_CR29","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.19.12.125001","volume":"19","author":"T Kurioka","year":"2014","unstructured":"Kurioka, T. et al. Characteristics of laser-induced shock wave injury to the inner ear of rats. J. Biomed. Opt. 19, 125001. https:\/\/doi.org\/10.1117\/1.JBO.19.12.125001 (2014).","journal-title":"J. Biomed. Opt."},{"key":"94080_CR30","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1002\/cne.903010309","volume":"301","author":"MC Liberman","year":"1990","unstructured":"Liberman, M. C., Dodds, L. W. & Pierce, S. Afferent and efferent innervation of the cat cochlea: quantitative analysis with light and electron microscopy. J. Comp. Neurol. 301, 443\u2013460 (1990).","journal-title":"J. Comp. Neurol."},{"key":"94080_CR31","doi-asserted-by":"publisher","first-page":"14077","DOI":"10.1523\/JNEUROSCI.2845-09.2009","volume":"29","author":"SG Kujawa","year":"2009","unstructured":"Kujawa, S. G. & Liberman, M. C. Adding insult to injury: cochlear nerve degeneration after \u201ctemporary\u201d noise-induced hearing loss. J. Neurosci. 29, 14077\u201314085 (2009).","journal-title":"J. Neurosci."},{"key":"94080_CR32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035238","volume":"7","author":"R Schaette","year":"2012","unstructured":"Schaette, R., Turtle, C. & Munro, K. J. Reversible induction of phantom auditory sensations through simulated unilateral hearing loss. PLoS ONE 7, e35238. https:\/\/doi.org\/10.1371\/journal.pone.0035238 (2012).","journal-title":"PLoS ONE"},{"key":"94080_CR33","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1152\/jn.00184.2013","volume":"111","author":"AE Hickox","year":"2014","unstructured":"Hickox, A. E. & Liberman, M. C. Is noise-induced cochlear neuropathy key to the generation of hyperacusis or tinnitus?. J. Neurophysiol. 111, 552\u2013564 (2014).","journal-title":"J. Neurophysiol."},{"key":"94080_CR34","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.neuroscience.2019.11.051","volume":"427","author":"KA Fernandez","year":"2020","unstructured":"Fernandez, K. A. et al. Noise-induced cochlear synaptopathy with and without sensory cell loss. Neuroscience 427, 43\u201357 (2020).","journal-title":"Neuroscience"},{"key":"94080_CR35","doi-asserted-by":"publisher","first-page":"13686","DOI":"10.1523\/JNEUROSCI.1783-13.2013","volume":"33","author":"Y Sergeyenko","year":"2013","unstructured":"Sergeyenko, Y., Lall, K., Liberman, M. C. & Kujawa, S. G. Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline. J. Neurosci. 33, 13686\u201313694 (2013).","journal-title":"J. Neurosci."},{"key":"94080_CR36","doi-asserted-by":"publisher","first-page":"3382","DOI":"10.1172\/JCI94351","volume":"128","author":"D Dulon","year":"2018","unstructured":"Dulon, D. et al. Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome. J. Clin. Invest. 128, 3382\u20133401 (2018).","journal-title":"J. Clin. Invest."},{"key":"94080_CR37","first-page":"555","volume":"5","author":"MP Osborne","year":"1991","unstructured":"Osborne, M. P. & Comis, S. D. Preparation of inner ear sensory hair bundles for high resolution scanning electron microscopy. Scan. Microsc. 5, 555\u2013564 (1991).","journal-title":"Scan. Microsc."},{"key":"94080_CR38","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1002\/cne.23688","volume":"523","author":"M Morell","year":"2015","unstructured":"Morell, M. et al. Ultrastructure of the Odontocete organ of Corti: scanning and transmission electron microscopy. J. Comp. Neurol. 523, 431\u2013448 (2015).","journal-title":"J. Comp. Neurol."},{"key":"94080_CR39","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0378-5955(86)90089-4","volume":"22","author":"DJ Lim","year":"1986","unstructured":"Lim, D. J. Functional structure of the organ of Corti: a review. Hear. Res. 22, 117\u2013146 (1986).","journal-title":"Hear. Res."},{"key":"94080_CR40","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1121\/1.406695","volume":"93","author":"RP Hamernik","year":"1993","unstructured":"Hamernik, R. P., Ahroon, W. A., Hsueh, K. D., Lei, S. F. & Davis, R. I. Audiometric and histological differences between the effects of continuous and impulsive noise exposures. J. Acoust. Soc. Am. 93, 2088\u20132095 (1993).","journal-title":"J. Acoust. Soc. Am."},{"key":"94080_CR41","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/S0196-0644(99)70225-8","volume":"34","author":"D Leibovici","year":"1999","unstructured":"Leibovici, D., Gofrit, O. N. & Shapira, S. C. Eardrum perforation in explosion survivors: is it a marker of pulmonary blast injury?. Ann. Emerg. Med. 34, 168\u2013172 (1999).","journal-title":"Ann. Emerg. Med."},{"key":"94080_CR42","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/978-981-13-6123-4_3","volume":"1130","author":"J Wang","year":"2019","unstructured":"Wang, J., Yin, S., Chen, H. & Shi, L. Noise-induced cochlear synaptopathy and ribbon synapse regeneration: repair process and therapeutic target. Adv. Exp. Med. Biol. 1130, 37\u201357 (2019).","journal-title":"Adv. Exp. Med. Biol."},{"key":"94080_CR43","doi-asserted-by":"publisher","first-page":"24907","DOI":"10.1038\/srep24907","volume":"6","author":"J Suzuki","year":"2016","unstructured":"Suzuki, J., Corfas, G. & Liberman, M. C. Round-window delivery of neurotrophin 3 regenerates cochlear synapses after acoustic overexposure. Sci. Rep. 6, 24907. https:\/\/doi.org\/10.1038\/srep24907 (2016).","journal-title":"Sci. Rep."},{"key":"94080_CR44","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.572434","volume":"14","author":"Y Koizumi","year":"2020","unstructured":"Koizumi, Y., Ito, T., Mizutari, K. & Kakehata, S. Regenerative effect of a ROCK inhibitor, Y-27632, on excitotoxic trauma in an organotypic culture of the cochlea. Front. Cell. Neurosci. 14, 572434. https:\/\/doi.org\/10.3389\/fncel.2020.572434 (2020).","journal-title":"Front. Cell. Neurosci."},{"key":"94080_CR45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046355","volume":"7","author":"SM Yang","year":"2012","unstructured":"Yang, S. M. et al. Regeneration of stereocilia of hair cells by forced Atoh1 expression in the adult mammalian cochlea. PLoS ONE 7, e46355. https:\/\/doi.org\/10.1371\/journal.pone.0046355 (2012).","journal-title":"PLoS ONE"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-94080-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-94080-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-94080-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T06:41:23Z","timestamp":1670049683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-94080-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,19]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["94080"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-94080-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,19]]},"assertion":[{"value":"22 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14704"}}