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To improve both diagnosis and the selection of patients for surgery, there is a pressing need to develop a reliable and objective test of ulnar nerve \u2018health\u2019. Diffusion tensor imaging (DTI) characterises tissue microstructure and may identify differences in the normal ulnar from those affected by CuTS. The aim of this study was to compare the DTI metrics from the ulnar nerves of healthy (asymptomatic) adults and patients with CuTS awaiting surgery. DTI was acquired at 3.0\u00a0T using single-shot echo-planar imaging (55 axial slices, 3\u00a0mm thick, 1.5 mm<jats:sup>2<\/jats:sup> in-plane) with 30 diffusion sensitising gradient directions, a b-value of 800\u00a0s\/mm<jats:sup>2<\/jats:sup> and 4 signal averages. The sequence was repeated with the phase-encoding direction reversed. Data were combined and corrected using the FMRIB Software Library (FSL) and reconstructed using generalized q-sampling imaging in DSI Studio. Throughout the length of the ulnar nerve, the fractional anisotropy (FA), quantitative anisotropy (QA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) were extracted, then compared using mixed-effects linear regression. Thirteen healthy controls (8 males, 5 females) and 8 patients with CuTS (6 males, 2 females) completed the study. Throughout the length of the ulnar nerve, diffusion was more isotropic in patients with CuTS. Overall, patients with CuTS had a 6% lower FA than controls, with the largest difference observed proximal to the cubital tunnel (mean difference 0.087 [95% CI 0.035, 0.141]). Patients with CuTS also had a higher RD than controls, with the largest disparity observed within the forearm (mean difference 0.252\u2009\u00d7\u200910<jats:sup>\u20134<\/jats:sup>\u00a0mm<jats:sup>2<\/jats:sup>\/s [95% CI 0.085\u2009\u00d7\u200910<jats:sup>\u20134<\/jats:sup>, 0.419\u2009\u00d7\u200910<jats:sup>\u20134<\/jats:sup>]). There were no significant differences between patients and controls in QA, MD or AD. Throughout the length of the ulnar nerve, the fractional anisotropy and radial diffusivity in patients with CuTS are different to healthy controls. These findings suggest that DTI may provide an objective assessment of the ulnar nerve and potentially, improve the management of CuTS.<\/jats:p>","DOI":"10.1038\/s41598-021-94211-7","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T10:04:09Z","timestamp":1626948249000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Diffusion tensor imaging in cubital tunnel syndrome"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5993-8525","authenticated-orcid":false,"given":"Timothy T.","family":"Griffiths","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0458-1802","authenticated-orcid":false,"given":"Robert","family":"Flather","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6705-3129","authenticated-orcid":false,"given":"Irvin","family":"Teh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3506-8430","authenticated-orcid":false,"given":"Hamied A.","family":"Haroon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Shelley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0997-4384","authenticated-orcid":false,"given":"Sven","family":"Plein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0059-8543","authenticated-orcid":false,"given":"Grainne","family":"Bourke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8365-6547","authenticated-orcid":false,"given":"Ryckie G.","family":"Wade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"issue":"3","key":"94211_CR1","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1177\/1753193419886741","volume":"45","author":"S Hulkkonen","year":"2020","unstructured":"Hulkkonen, S. et al. 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