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How to manage these patients with initial NKPS failure has not been well studied. We report the outcomes of patients who received endoscopic and non-endoscopic rescue treatment after the initial NKPS failure. During the 15\u00a0years from 2004 to 2018, 87 patients with initial NKPS failure received interval endoscopic treatment (IET group, n\u2009=\u200943), percutaneous transhepatic biliary drainage (PTBD group, n\u2009=\u200925), or bile duct surgery (BDS group, n\u2009=\u200919) were retrospectively studied. Compared with the PTBD group, the prevalence of choledocholithiasis was higher (69.8% vs. 16.0%, p\u2009&lt;\u20090.001), and malignant bile duct stricture were lower (20.9% vs. 76.0%, p\u2009&lt;\u20090.001) in the IET group. Furthermore, the IET group had a significantly longer time interval between the first and second treatment procedures (4\u00a0days vs. 2\u00a0days, p\u2009=\u20090.001), a lower technique success rate (79.1% vs. 100%, p\u2009=\u20090.021), and a shorter length of hospital stay (7\u00a0days vs. 18\u00a0days, p\u2009&lt;\u20090.001). Compared to the BDS group, the only significant finding was that the patients in the IET group were older. Although not statistically significant, the complication rate was lowest in the IET group (7.0%) while highest in the BDS group (15.8%). Complications in the IET group were also mild, as compared with the other two groups. In conclusion, IET should be considered after initial failed NKPS for deep biliary cannulation before contemplating more invasive treatment such as BDS. PTBD may be the alternative therapy for patients with malignant biliary obstruction.<\/jats:p>","DOI":"10.1038\/s41598-021-94361-8","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T10:04:09Z","timestamp":1626948249000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Management of biliary diseases after the failure of initial needle knife precut sphincterotomy for biliary cannulation"],"prefix":"10.1038","volume":"11","author":[{"given":"Min-Hao","family":"Lo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Hui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Huan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Kuan","family":"Tsou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu-Hsien","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Feng","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai-Jen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"key":"94361_CR1","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1111\/j.1572-0241.2002.05829.x","volume":"97","author":"GC Harewood","year":"2002","unstructured":"Harewood, G. 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