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A receiver operator characteristics (ROC) analysis showed the \u0394-HbO* cutoffs of \u2212\u20090.175 at left PFC and \u2212\u20090.205 at right PFC offer sensitivity and specificity of at least 80% in screening fibromyalgia from controls. In fibromyalgia, a ROC analysis showed that these cutoffs could discriminate those with higher disability due to pain and more severe central sensitization symptoms (CSS). The ROC with the best discriminatory profile was the CSS score with the \u0394-HbO* at left PFC (area under the curve\u2009=\u20090.82, 95% confidence interval\u2009=\u20090.61\u2013100). 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