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Identification of patients at risk for sepsis and poor outcome is therefore of outmost importance. We performed a nation-wide case\u2013control study aiming at identifying and quantifying the association between co-morbidity and socio-economic factors with intensive care admission for community-acquired sepsis. We also explored 30-day mortality. All adult patients (n\u2009=\u200910,072) with sepsis admitted from an emergency department to an intensive care unit in Sweden between 2008 and 2017 and a control population (n\u2009=\u200950,322), matched on age, sex and county were included. In the sepsis group, 69% had a co-morbid condition at ICU admission, compared to 31% in the control group. Multivariable conditional logistic regression analysis was performed and there was a large variation in the influence of different risk factors associated with ICU-admission, renal disease, liver disease, metastatic malignancy, substance abuse, and congestive heart failure showed the strongest associations. Low\u00a0income and\u00a0low\u00a0education\u00a0level\u00a0were more common in\u00a0sepsis\u00a0patients\u00a0compared to\u00a0controls.\u00a0The adjusted OR for 30-day mortality for sepsis patients was 132 (95% CI 110\u2013159) compared to controls.<\/jats:p>","DOI":"10.1038\/s41598-021-94558-x","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T10:03:49Z","timestamp":1627034629000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Nationwide case\u2013control study of risk factors and outcomes for community-acquired sepsis"],"prefix":"10.1038","volume":"11","author":[{"given":"Ann-Charlotte","family":"Lindstr\u00f6m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"M\u00e5rtensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Oldner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"key":"94558_CR1","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1378\/chest.11-0352","volume":"140","author":"G Kumar","year":"2011","unstructured":"Kumar, G. et al. 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