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Therefore, we assessed the prevalence of rs67085638 in patients with gastric cancer (GC). We also evaluated the effect of rs67085638 on B-cell-specific Moloney leukaemia virus insertion site 1 (BMI1) transcripts in primary GC and counterpart histopathologically confirmed disease-free margin tissue. Using high-resolution melting analysis, we evaluated rs67085638 frequency in patients with the GC genotype (n\u2009=\u2009214) and controls (n\u2009=\u2009502) in a Polish Caucasian population. qRT-PCR was used to determine BMI1 transcripts. We observed the trend of rs67085638 association in all patients with GC (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.028), a strong risk of the GC genotype in male (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.035) but not female (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.747) patients, and the association with non-cardia GC (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.041), tumour stages T3 (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.014) and T4 (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.032), differentiation grading G3 (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.009), lymph node metastasis stage N3 (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.0005) and metastasis stage M0 (<jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u20090.027). We found that significantly increased BMI1 transcripts were associated with the primary GC genotype classified as grade G3 (<jats:italic>p<\/jats:italic>\u2009=\u20090.011) and as lymph node metastasis N3 (<jats:italic>p<\/jats:italic>\u2009=\u20090.010) and counterpart marginal tissues (<jats:italic>p<\/jats:italic>\u2009=\u20090.026, <jats:italic>p<\/jats:italic>\u2009=\u20090.040, respectively) from carriers of the T\/T versus C\/C genotypes. rs67085638 may contribute to increased BMI1 transcripts and the progression and rapid growth of GC.<\/jats:p>","DOI":"10.1038\/s41598-021-94576-9","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T10:02:43Z","timestamp":1627466563000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long noncoding RNA CCAT1 rs67085638 SNP contribution to the progression of gastric cancer in a Polish population"],"prefix":"10.1038","volume":"11","author":[{"given":"Tomasz","family":"Olesi\u0144ski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Lutkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Balcerek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Sowi\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Piotrowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Trzeciak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Maj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Hevelke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawel P.","family":"Jagodzi\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"issue":"4","key":"94576_CR1","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1001\/jamaoncol.2015.0735","volume":"1","author":"C Fitzmaurice","year":"2015","unstructured":"Global Burden of Disease Cancer Collaboration et al. 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